In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Wu, Yafeng; Zhang, Fen; Wang, Kan; Luo, Peicheng; Wei, Yuanqing; Liu, Songqin. Category: imidazoles-derivatives. The article was titled 《Activatable Fluorescence Imaging and Targeted Drug Delivery via Extracellular Vesicle-Like Porous Coordination Polymer Nanoparticles》. The information in the text is summarized as follows:
Cancer imaging with minimal background signal and targeted intracellular drug delivery are of vital importance in clin. cancer diagnosis and therapy. Herein, we developed a biomimetic nanoprobe for activated fluorescence imaging and targeted drug delivery. PH-responsive porous coordination polymer nanoparticles (PCP NPs) were first synthesized by a codeposition method, anticancer drug doxorubicin (DOX) was then loaded into PCP NPs through phys. and electrostatic adsorption (PCP-DOX), and finally the cell membranes extracted from Bel-7402 cancer cells were coated on the DOX-loaded PCP NPs (PCP-DOX-CM). The fluorescence of DOX was quenched due to the fluorescence resonance energy transfer between DOX and PCP NPs. Under acidic environment inside cancer cells, PCP NPs degraded, DOX was released from PCP-DOX-CM, and the fluorescence of DOX was activated, which was very specific for cancers with a high signal-to-noise ratio. Benefited from immune escaping and homologous targeting ability from cancer cell membranes, compared with PCP-CM and PCP-DOX, PCP-DOX-CM significantly enhanced the cellular endocytosis of DOX in Bel-7402 cancer cells and exhibited excellent cancer therapy effect in vitro. Together, our work provides a useful platform for an activated cancer imaging system and personalized cancer treatment. After reading the article, we found that the author used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Category: imidazoles-derivatives)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem