Collins, Mark A.; Hudak, Valerie; Bender, Reinhold; Fensome, Andrew; Zhang, Puwen; Miller, Lori; Winneker, Richard C.; Zhang, Zhiming; Zhu, Yuan; Cohen, Jeffrey; Unwalla, Rayomond J.; Wrobel, Jay published the artcile< Novel pyrrole-containing progesterone receptor modulators>, Synthetic Route of 1003-21-0, the main research area is indolone pyrrolyl preparation progesterone receptor agonist antagonist; benzoxazinone pyrrolyl preparation progesterone receptor agonist antagonist.
A series of 1,4-dihydro-2H-[d][3,1]-benzoxazin-2-one and 1,3-dihydro-[3H]-indol-2-one containing 6- or 5-, resp., appended substituted pyrrole moieties were synthesized and evaluated for their ability to modulate the activity of the progesterone receptor (PR). Key structural changes to the pyrrole moieties of these mols. were shown to have a predictive influence as to whether the compounds behaved as PR agonists or antagonists. Compounds with the 5′-cyano-2′-pyrrole moiety were shown to be potent PR agonists (EC50’s of 1.1, 1.8, and 2.8 nM, resp.). Compounds with the 5′-nitro-2′-pyrrole moiety were shown to be PR antagonists (IC50’s of 180 and 36 nM, resp.).
Bioorganic & Medicinal Chemistry Letters published new progress about Progesterone receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Synthetic Route of 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem