Dong, Jianghong; Chen, Shengwei; Li, Runfeng; Cui, Wei; Jiang, Haiming; Ling, Yixia; Yang, Zifeng; Hu, Wenhui published the artcile< Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus>, Related Products of 36947-69-0, the main research area is imidazole pinanamine antiviral influenza virus; Dual inhibitory activity; Influenza A virus; M2 ion channel; Pinanamine derivatives.
The authors previously reported potent hit compound (I) inhibiting the wild-type influenza A virus A/HK/68 (H3N2) and A/M2-S31N mutant viruses A/WS/33 (H1N1), with its latter activity quite weak. To further increase its potency, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidazole ring of this compound Several compounds of this series inhibited the amantadine-sensitive virus at low micromolar concentrations Among them, (II) (R1,R2,R3=alkyl) was the most potent compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel. Furthermore, II markedly inhibited the amantadine-resistant virus (IC50 = 3.4 μM) and its activity increased by almost 24-fold compared to initial compound, with its action mechanism being not M2 channel mediated.
European Journal of Medicinal Chemistry published new progress about Antiviral agents. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Related Products of 36947-69-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem