Gao, Lingling; Nie, Xin; Gou, Rui; Hu, Yuexin; Dong, Hui; Li, Xiao; Lin, Bei published the artcile< Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells>, Quality Control of 6823-69-4, the main research area is ANXA ovarian cancer epithelial mesenchymal plasticity human peritoneal mesothelium; ANXA2; Implantation and metastasis; epithelial-mesenchymal plasticity; exosome; ovarian cancer.
Ovarian cancer, one of the malignant gynaecol. tumors with the highest mortality rate among female reproductive system, is prone to metastasis, recurrence and chemotherapy resistance, causing a poor prognosis. Exosomes can regulate the epithelial-mesenchymal plasticity of tumor cells, remodel surrounding tumor microenvironment, and affect tumor cell proliferation, invasion and metastasis. However, the function and mechanism of exosomes in the i.p. implantation of ovarian cancer remain unclear. In this study, exosomal annexin A2 (ANXA2) derived from ovarian cancer cells was co-cultured with human peritoneal mesothelial (HMrSV5) cells; functional experiments were conducted to explore the effects of exosomal ANXA2 on the biol. behavior of HMrSV5 and the related mechanisms. This study showed that ANXA2 in ovarian cancer cells can be transferred to HMrSV5 cells through exosomes, exosomal ANXA2 can not only promote the migration, invasion and apoptosis of HMrSV5 cells, but also regulates morphol. changes and fibrosis of HMrSV5 cells. Furthermore, ANXA2 promotes the mesothelial-mesenchymal transition (MMT) and degradation of the extracellular matrix of HMrSV5 cells through PI3K/AKT/mTOR pathway, finally affects pre-metastasis microenvironment of ovarian cancer, which provides a new theor. basis for the mechanism of i.p. implantation and metastasis of ovarian cancer.
Journal of Cellular and Molecular Medicine published new progress about Annexin A2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Quality Control of 6823-69-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem