Li, Jianhua; Liu, Kuancheng; Liu, Yang; Xu, Yan; Zhang, Fei; Yang, Huijuan; Liu, Jiangxia; Pan, Tingting; Chen, Jieliang; Wu, Min; Zhou, Xiaohui; Yuan, Zhenghong published the artcile< Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity>, Application of C30H30Cl2N6O2, the main research area is IFN alpha induced antiviral activity exosome cell transmission.
The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-α (IFN-α) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-α-treated LNPCs were rich in mols. with antiviral activity. Moreover, exosomes from LNPCs were internalized by hepatocytes, which mediated the intercellular transfer of antiviral mols. Finally, we found that exosomes also contributed to the antiviral response of IFN-α to mouse hepatitis virus A59 and adenovirus in mice. Thus, we propose an antiviral mechanism of IFN-α activity that involves the induction and intercellular transfer of antiviral mols. via exosomes.
Nature Immunology published new progress about Adenoviridae. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Application of C30H30Cl2N6O2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem