Shelton, Kerri L.; DeBord, Michael A.; Wagers, Patrick O.; Southerland, Marie R.; Williams, Travis M.; Robishaw, Nikki K.; Shriver, Leah P.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N’-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines》.Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The author mentioned the following in the article:
A series of N,N’-bis(arylmethyl)benzimidazolium salts have been synthesized and evaluated for their in vitro anticancer activity against select nonsmall cell lung cancer cell lines to create a structure activity relationship profile. The results indicate that hydrophobic substituents on the salts increase the overall antiproliferative activity. The data confirms that naphthylmethyl substituents at the nitrogen atoms (N1(N3)) and highly lipophilic substituents at the carbon atoms (C2 and C5(C6)) can generate benzimidazolium salts with antiproliferative activity that is comparable to that of cisplatin. The National Cancer Institute’s Developmental Therapeutics Program tested a number of synthesized compounds in their 60 human tumor cell line screen. Results were supportive of data observed in the laboratory Compounds with hydrophobic substituents have higher anticancer activity than compounds with hydrophilic substituents. The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)
3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Safety of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem