《Dual-Mode Fluorescence and Magnetic Resonance Imaging by Perylene Diimide-Based Gd-Containing Magnetic Ionic Liquids》 was written by Yu, Xiaoliang; Yuan, Xiaoyan; Huang, Zitan; Zhang, Wenyu; Huang, Fan; Ren, Lixia. Application of 616-47-7 And the article was included in ACS Biomaterials Science & Engineering in 2020. The article conveys some information:
Bioimaging plays a key role in the diagnosis/treatment of diseases and in scientific research studies. Compared with single imaging techniques, dual-mode and multimode imaging techniques facilitate high accuracy. In this work, a perylene diimide (PDI)-based Gd-containing magnetic ionic liquid, Per-6-Diimi[Gd(NO3)4], is reported for dual-modal imaging, in which a Gd(III) complex was used for magnetic resonance imaging (MRI), while PDI was used for fluorescence imaging. Because of the difference in the biol. microenvironment, there is a switch between dispersed and aggregated states of Per-6-Diimi[Gd(NO3)4] mols. in hydrophobic and hydrophilic media. When it was in the aqueous solution, the intensive π-π interaction of PDI cores made Per-6-Diimi[Gd(NO3)4] aggregates to form particles. The paramagnetic nanoparticles ensure prolonging the rotational correlation time, which results in a strong enhancement of MRI with a longitude relaxation coefficient of 14.94 mM-1 s-1. In an in vivo MRI experiment, the tumor site is imaged by MRI through the enhanced permeability and retention effect. However, when the mol. is present on the hydrophobic membrane of the cells, the dispersed Per-6-Diimi[Gd(NO3)4] showed good fluorescence imaging capabilities due to the high fluorescence quantum yield of PDI. Thus, the fluorescence imaging of cells can be carried out. Moreover, ex vivo fluorescence imaging of organs is performed after MRI. Per-6-Diimi[Gd(NO3)4] is enriched in the liver, kidneys, and tumors. The results came from multiple reactions, including the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Application of 616-47-7)
1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Application of 616-47-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem