In 2017,Gund, Dnyandev Radhu; Tripathi, Alok Pramod; Vaidya, Sanjay Dashrath published 《Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles》.European Journal of Chemistry published the findings.Name: 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:
Synthesis of a series of new substituted benzimidazole derivatives by the condensation of o-phenylenediamine with urea to give 1,3-dihydro-benzimidazol-2-one which reacted with phosphoryl chloride to give 2-chloro-1H-benzimidazole is reported. The product was then alkylated at the benzimidazole NH with different electrophilic reagents leading to functionalized derivatives Structures of the newly synthesized products have been deduced on the basis of spectral and anal. data. The synthesized compounds were screened for their antimicrobial activity. This exhibited some promising results towards testing organism in-vitro. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Name: 2-Chloro-1H-benzo[d]imidazole)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Name: 2-Chloro-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem