Fan, Guang-Gao; Jiang, Bo-Wen; Sang, Wei; Cheng, Hua; Zhang, Rui; Yu, Bao-Yi; Yuan, Ye; Chen, Cheng; Verpoort, Francis published an article in 2021. The article was titled 《Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol》, and you may find the article in Journal of Organic Chemistry.Computed Properties of C7H5ClN2 The information in the text is summarized as follows:
Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallog. anal. of 1-Methyl-N-phenyl-1H-benzo[d]imidazol-2-amine hydrochloride played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug mols., which demonstrated its practical value for further applications. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem