Lafzi, Ferruh; Kilic, Deryanur; Yildiz, Melike; Saracoglu, Nurullah published an article in 2021. The article was titled 《Design, synthesis, antimicrobial evaluation, and molecular docking of novel chiral urea/thiourea derivatives bearing indole, benzimidazole, and benzothiazole scaffolds》, and you may find the article in Journal of Molecular Structure.Reference of 1H-Benzo[d]imidazol-2-amine The information in the text is summarized as follows:
Urea/thiourea derivatives with heteroaromatic scaffolds such as indole I [X = O, S], benzimidazole II, and benzothiazole were designed, synthesized and evaluated for their potential antimicrobial activity in vitro assays to establish against B. cereus, S. aureus, E. coli, and P. aeruginosa. Results indicated that compounds were only active in gram-pos. bacteria. Mol. docking studies were carried out for the most efficient compounds to understand the interactions with proteins involved in peptidoglycan synthesis. ADME calculations indicated that these compounds were more likely to be taken via the oral route. In summary, these findings may contribute to the design and development of candidates for more effective therapeutics in biol. systems. In the experimental materials used by the author, we found 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Reference of 1H-Benzo[d]imidazol-2-amine)
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Reference of 1H-Benzo[d]imidazol-2-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem