Pilette, Charles published the artcile< Role of exosomes in allergic asthma: Signaling platforms between the epithelium and type 2 immunity>, Recommanded Product: p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride, the main research area is exosome allergic asthma signaling epithelium immunity; Asthma; Notch; contactin-1; type 2 immunity.
Exosomes activate (and are uptaken by) monocyte-derived, inflammatory dendritic cells (DCs) through contactin-1 and Notch2 activation, which in turn promotes TH2 cell-and TH17 cell-polarized immune activation along with mucus production and smooth muscle hyperresponsiveness. Airway epithelial cells release increased numbers of CD631 and CD811 exosomes following stimulation by house dust mite (HDM), a major allergen in allergic airway diseases such as rhinitis and asthma, and that those exosomes are also released in the bronchoalveolar lavage fluid from HDM-exposed mice. To address the role of these exosomes in the pathophysiol. of asthma, exosomes’ release by using GW4869, a noncompetitive inhibitor blocking exosome synthesis and/or release, which resulted in reduced recruitment of eosinophils in the bronchoalveolar lavage fluid from HDM-exposed and HDM-challenged mice. Airway tissue infiltration by inflammatory cells, mucus production, and levels of type 2 cytokines (IL-4, IL-5, and IL-13), as well as IFN-g levels but not IL-17A levels, were also downregulated.
Journal of Allergy and Clinical Immunology published new progress about Allergic asthma. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Recommanded Product: p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem