In 2018,Sakata, Yosuke; Yabunaka, Kosuke; Kobayashi, Yuko; Omiya, Hirohisa; Umezawa, Naoki; Kim, Hye-Sook; Wataya, Yusuke; Tomita, Yoshimi; Hisamatsu, Yosuke; Kato, Nobuki; Yagi, Hirokazu; Satoh, Tadashi; Kato, Koichi; Ishikawa, Haruto; Higuchi, Tsunehiko published 《Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme》.ACS Medicinal Chemistry Letters published the findings.COA of Formula: C7H5ClN2 The information in the text is summarized as follows:
Based on the idea that compounds designed to exhibit high affinity for heme would block hemozoin formation, a critical heme-detoxification process for malarial parasites, we synthesized a series of compounds with two π-conjugated moieties at terminal amino groups of triamine. These compounds exhibited moderate to high antimalarial activities in vitro toward both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. In a P. berghei-infected mouse model, 3a and 12a showed potent antimalarial activities compared to artesunate, as well as a prolonged duration of antimalarial effect. We found a good correlation between protective activity against hemin degradation and antimalarial activity. Compounds 8b and 3a strongly inhibited hemozoin formation catalyzed by heme detoxification protein. After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1COA of Formula: C7H5ClN2)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.COA of Formula: C7H5ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem