Product Details of 2403-66-9On September 12, 2005 ,《Selective nitrogen protection of hydroxyalkylbenzimidazoles using 2,2,2-trichloroethylchloroformate》 was published in Tetrahedron Letters. The article was written by Woudenberg, Richard C.; Coughlin, E. Bryan. The article contains the following contents:
A method for selective N-protection of hydroxyalkylbenzimidazoles using 2,2,2-trichloroethylchloroformate (Troc-Cl) applicable to various alkyl chain lengths was developed. In the specific case of 5-(1-[2,2,2-trichloroethyl formyl]-benzimidazol-2-yl)-propan-1-ol, migration of Troc from the benzimidazole to the primary alc. occurs in the presence of triethylamine, allowing the choice of selective N-Troc or O-Troc protection. After reading the article, we found that the author used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Product Details of 2403-66-9)
3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Product Details of 2403-66-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem