Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Quality Control of 60-56-0.
Khalili, Zeinab;Nezhadali, Azizollah research published 《 Nanomolar detection of lansoprazole: computational-assisted to monomer-templet complex study based on molecularly imprinted polymer and electrochemical determination》, the research content is summarized as follows. Herein, a sensitive electrochem. sensor based on a molecularly imprinted polymer (MIP) was developed to measure the lansoprazole (LNS). The most suitable monomer was chosen by a computational method. A cyclic voltammetry technique was used to synthesize the sensor by electro-polymerization of pyrrole on a pencil graphite electrode in the presence of a template mol. The differential pulse voltammetry technique was performed for all measurements. The characterization of the modified sensor was investigated by SEM. To optimize the critical factors, the Plackett-Burman design and central composite design methods were done. Linear range of 10-1000μM and correlation coefficients (R2) of 0.9846 were obtained by plotting the calibration curve under optimal conditions. The limit of detection and the limit of quantitation were determined as 0.031μM (S/N = 3) and 0.075μM (S/N = 10), resp. Finally, the proposed sensor was successfully applied to LNS determination in capsule and serum samples.
Quality Control of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem