Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 10111-08-7.
Li, Jingyao;Di Lorenzo, Vincenzo;Patil, Pravin;Ruiz-Moreno, Angel J.;Kurpiewska, Katarzyna;Kalinowska-Tluscik, Justyna;Velasco-Velazquez, Marco A.;Doemling, Alexander research published 《 Scaffolding-Induced Property Modulation of Chemical Space》, the research content is summarized as follows. Tetrazole- and heterocycle-containing amino alcs. were prepared by Ugi reactions; the amino alcs. underwent cyclization reactions with carbonyl-, thiocarbonyl-, and sulfonyldiimidazole to yield cyclized products, including benzoxazinones and benzoxazepanones, such as I. Two pyrrole- and imidazole-containing amines were also prepared using Ugi reactions; cyclization reactions with carbonyldiimidazole yielded fused imidazolidinones. The properties (lipophilicity, polar surface area, mol. shape) of virtual libraries of uncyclized and cyclized products were compared. The structures of five of the cyclized products were determined by X-ray crystallog.
Synthetic Route of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem