Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Application In Synthesis of 3034-50-2.
Li, Mengyuan;Sheth, Sujitraj;Xu, Yalan;Song, Qijun research published 《 Ru(II)-bipyridine complex as a highly sensitive luminescent probe for Cu2+ detection and cell imaging》, the research content is summarized as follows. A novel ruthenium(II) polypyridine complex with an imidazole group linked with a conjugated structure has been synthesized and functioned as a novel luminescent probe for the quick and accurate detection of Cu2+. The coordination with Cu2+ resulted into the formation of stable cyclic structure which leads to luminescence quenching of RuL at the 621 nm. Under the optimal conditions, the linear concentration range was obtained from 0.25-12.0 microM and the corresponding detection limits were calculated to be 83.3 nM (S/N = 3) which is far lower than prescribed permissible limit by World Health Organization. The developed RuL luminescent probe has been applied for the detection of Cu2+ in environmental water sample successfully. Furthermore, the RuL probe applied in the cell imaging for detection of Cu2+, indicating its suitability for application in vivo. Thus, a simple and quick method has been established with high sensitivity and specificity for the detection of Cu2+.
Application In Synthesis of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem