Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. SDS of cas: 3034-50-2.
Lin, Junqi;Chen, Xin;Wang, Nini;Liu, Shanshan;Ruan, Zhijun;Chen, Yanmei research published 《 Electrochemical water oxidation by a copper complex with an N4-donor ligand under neutral conditions》, the research content is summarized as follows. Herein, electrochem. water oxidation catalyzed by a copper(II) complex [CuII(H2L)](NO3)2 with the redox-active salophen-like N4-donor ligand N,N′–bis-(1H-imidazol-4-yl)methylidene-o-phenylenediamine is demonstrated. Oxygen evolution with a high turnover frequency of 11.09 s-1 and a low onset overpotential of only 580 mV is achieved in neutral phosphate buffer solution, and [CuII(H2L)]2+ is confirmed as an efficient mol. water oxidation catalyst with long-term stability. The results of electrochem. tests provide evidence that the Cu center undergoes a water nucleophilic attack process and participates in the catalytic cycle. The subsequent one-step proton-coupled electron transfer (PCET) process of the Cu center and the two-step PCET process of the ligand are both critical for efficient water oxidation This work indicates that the ligand assisted catalytic cycle is a favorable method for the accumulation of intermediate species that account for electrochem. water oxidation
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, SDS of cas: 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem