Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Related Products of 10111-08-7.
Longnecker, Emmaline R.;Metz, Lucy;Miller, Rebecca S.;Berke, Andrew E. research published 《 Probing Liquid-Liquid Phase Separation in Secondary Organic Aerosol Mimicking Solutions Using Articulated Straws》, the research content is summarized as follows. The presence or absence of liquid-liquid phase separation (LLPS) in aerosol particles containing oxidized organic species and inorganic salts affects particle morphol. and influences uptake into, diffusion through, and reactivity within those particles. We report here an accessible method, similar to ice core analyses, using solutions that are relevant for both aerosol chem. systems and aqueous two-phase extraction systems and contain ammonium sulfate and one of eight alcs. (methanol, ethanol, 1-propanol, 2-propanol, 2-butaonol, 3-methyl-2-butanol, 1,2-propanediol, or 1,3-propanediol) frozen in articulated (bendable) straws to probe LLPS. For alcs. with neg. octanol-water partitioning coefficient (KOW) values and O/C ratios ≥0.5, no LLPS occurs, while for alcs. with pos. KOW values and O/C ratios ≤0.33, phase separation always occurs, both findings consistent with observations using different exptl. techniques. When a third species, glyoxal, is added, the glyoxal stays in the aqueous phase, regardless of whether LLPS occurs. When phase separation occurs, the glyoxal forms a strong intermol. interaction with the sulfate ion, red-shifting the ν3(SO42-) peak by 15 cm-1. These results provide evidence of chem. interactions within phase-separated systems that have implications for understanding chem. reactivity within those, and related, systems.
10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Related Products of 10111-08-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem