Imidazole based anticancer drug find applications in cancer chemotherapy. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Electric Literature of 60-56-0.
Nezhadali, Azizollah;Khalili, Zeinab research published 《 Computer-aided study and multivariate optimization of nanomolar metformin hydrochloride analysis using molecularly imprinted polymer electrochemical sensor based on silver nanoparticles》, the research content is summarized as follows. In this research project, a selective and sensitive sensor was electrochem. designed to measure metformin hydrochloride (MET) based on molecularly imprinted polymer (MIP). To prepare the sensor, the polypyrrole was electrochem. synthesized on a pencil graphite electrode (PGE), which modified with silver nanoparticles (AgNPs). Cyclic voltammetry and differential pulse voltammetry techniques were performed to fabricate the sensor and quant. measurements, resp. To select the functional monomers, a computational method was used. Some critical factors controlling the performance of the MIP-AgNPs-PGE were optimized using Plackett-Burman design and central composite design methods. Under optimal conditions, a calibration curve was obtained in the range 0.1-1000μM with a limit of detection of 6.8 nM (S/N = 3, n = 3) and limit of quantitation of 22.8 nM (S/N = 10, n = 3). RSD of 3.9 and 4.1% were obtained for repeatability and reproducibility of the system, resp. Furthermore, the modified sensor was successfully used for the determination of MET concentration in some real samples.
Electric Literature of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem