Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. COA of Formula: C27H37ClN2.
Oliveira, Joao C. A.;Dhawa, Uttam;Ackermann, Lutz research published 《 Insights into the Mechanism of Low-Valent Cobalt-Catalyzed C-H Activation》, the research content is summarized as follows. The use of cobalt complexes of N-heterocycle carbene (NHC) ligands as catalysts for C-H activation is extremely advantageous due to their low costs and high efficiencies at room temperature These catalysts have been proposed to operate in low oxidation states and have successfully been applied in C-H alkylations as well as C-H arylations, among others. Despite these indisputable advances, detailed mechanistic insights into their exact working mode continue to be scarce. Herein, we present extensive DFT and DLPNO-CCSD(T) computational studies, which provide strong support for a mechanism via low-valent cobalt-catalyzed C-H activations. Our findings indicate the key C-H metalation to proceed through a ligand-to-ligand hydrogen transfer (LLHT) pathway rather than a classical oxidative addition mechanism.
COA of Formula: C27H37ClN2, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem