Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 60-56-0.
Onoda, Michika;Jia, Fei;Takeoka, Yukikazu;Macfarlane, Robert J. research published 《 Controlling the dynamics of elastomer networks with multivalent brush architectures》, the research content is summarized as follows. Herein, we report a design strategy for developing mech. enhanced and dynamic polymer networks by incorporating a polymer with multivalent brush architecture. Different ratios of two types of imidazole functionalized polymers, specifically poly(Bu acrylate) (PnBA) and poly(poly(Bu acrylate)) (PPnBA) were blended with Zn(II) ions, thereby forming a series of elastomers with consistent composition but varying network topologies. As the weight fraction of PPnBA increased, the melting temperature, plateau modulus, and relaxation time of the melt increased because of the increase in the crosslinking d. and coordination efficiency. Remarkably, however, the activation energy of the flow, Ea, decreased with increasing amounts of PPnBA despite the observed increases in mech. properties. This unique behavior is attributed to the multivalent nature of the brush polymer, which allows the PPnBA to generate a higher crosslinking d. than networks of linear PnBA, even though the brush polymers contain a lower weight fraction of the imidazole crosslinks. This method of lowering Ea, while improving the mech. properties of the elastomers has great potential in the development of various soft materials such as self-healing or 3D-printable elastomeric structures.
Synthetic Route of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem