Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Name: 1-Methyl-1H-imidazole-2(3H)-thione.
Saheb, Vahid;Shamspur, Tayebeh research published 《 Rapid analysis of chromium (III, VI) in water and wastewater samples based on Task-specific ionic liquid by the ultra-assisted dispersive ionic liquid-liquid microextraction》, the research content is summarized as follows. Exposure to hexavalent chromium (Cr VI) causes cancer in cells of the human body. So, the speciation and determination of the Cr (VI) and Cr (III) in water and human samples based on sensitive techniques are necessary. In this research, 2-mercapto-1-methylimidazole a novel Task-specific ionic liquid (C4H6N2S; HS-CH3-IM) was used with a new approach for speciation of Cr (III, VI) from water samples by ultra-assisted dispersive ionic liquid-liquid microextraction procedure (USA-D-ILLME). Due to the procedure, 100 mg of HS-CH3-IM and 0.2 mL of acetone were mixed and injected into 10 mL of water or standard Cr (III) and Cr (VI) solution in the conical tube. After stirring for 5 min, the Cr (VI) and Cr (III) were extracted with a pos. and neg. charge of the thiol group (HS2+, HS–) in pH 2 or 8 and pH 5, resp. The mixture of the HS-CH3-IM was collected at the bottom of the conical tube by centrifuging. The upper liquid phase was vacuumed with a peristaltic pump and the Cr (III, VI) loaded on the HS-CH3-IM was back-extracted in a liquid solution Finally, the concentration of the Cr (III, VI) ions in a remained solution were measured with ET-AAS after dilution up to 0.5 mL with DW. The total chromium was determined in water samples by summarizing the Cr (VI) and Cr (III) contents. All parameters such as the amount of HS-CH3-IM, the sample volume, pH, and the shaking/centrifuging time were optimized. Under the optimal conditions, good linear range (LR), LOD, and enrichment factor (EF) were obtained 0.05-1.7 μg L-1, 15 ng L-1, and 19.82 resp. (RSD% < 1.45). The procedure was validated by spiking samples and good accuracy and precision results were achieved.
Name: 1-Methyl-1H-imidazole-2(3H)-thione, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem