The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. SDS of cas: 250285-32-6.
Shepelenko, Konstantin E.;Soliev, Safarmurod B.;Galushko, Alexey S.;Chernyshev, Victor M.;Ananikov, Valentine P. research published 《 Different effects of metal-NHC bond cleavage on the Pd/NHC and Ni/NHC catalyzed α-arylation of ketones with aryl halides》, the research content is summarized as follows. Recently, the dynamic nature of the metal-NHC bond has been proposed and the key role of chem. evolution in changing the nature of catalytically active sites is now an emerging topic. A comparative anal. of the ketone α-arylation reaction with aryl halides, catalyzed by M/NHC complexes, was carried out in the present study and showed a fundamental difference in the behavior of the catalytic system for M = Ni and Pd. In situ evolution of Ni/NHC complexes with cleavage of the Ni-NHC bond leads to complete deactivation of catalytic systems, regardless of the nature of the aryl halide ArX (X = Cl, Br, I). However, upon Pd/NHC catalysis, the cleavage of the Pd-NHC bond causes deactivation only in the case of aryl chlorides. In the reactions of more active aryl iodides and aryl bromides, NHC-disconnected Pd species, formed as a result of the chem. transformation of Pd/NHC complexes, can provide effective catalysis in the arylation reaction under study. New catalytic systems based on Pd/NHC and Ni/NHC complexes generated in situ from stable imidazolium salts, IPr·HCl and IPr*OMe·HCl, and Pd(OAc)2 (0.1 mol%) or NiCl2Py2 (5 mol%) were developed for the selective α-arylation of methylaryl ketones (Pd-catalysis) and other ketones less prone to aldol-crotonic condensation (Ni-catalysis). The present study has shown that the different effects of the metal-NHC bond cleavage should be taken into account for the efficient choice and optimization of catalytic systems to carry out arylation reaction with various aryl halides.
SDS of cas: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem