Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Formula: C5H8N2.
Zhou, Li;Wang, Zhenyu;Xu, Guangqiang;Lv, Chengdong;Wang, Qinggang research published 《 Structure and activity relationship studies of N-heterocyclic olefin and thiourea/urea catalytic systems: application in ring-opening polymerization of lactones》, the research content is summarized as follows. A highly efficient and controllable ring-opening polymerization of lactones (δ-valerolactone, ε-caprolactone and rac-lactide) has been achieved by using N-heterocyclic olefin (NHO) and thiourea/urea (TU/U) catalytic systems. This catalytic system showed high ring-opening activity and stereoselectivity, delivering biodegradable polyesters with high chain-end fidelity, controlled mol. weights and narrow molar mass dispersities. A detailed investigation of the structure-activity relationship was performed by exploring five NHOs and fourteen TUs/Us. For a fixed NHO, when the acidity of TUs/Us decreases, the polymerization mechanism changes from the (thio)urea anion to the neutral cooperative activation mode, and the catalytic activity first increases and decreases, displaying a highly effective interval. For a given TU or U, as the basicity of NHOs increases, the catalytic performance improves correspondingly. Besides, highly isoselective ROP of rac-LA (Pm = 0.93) at -78° has been also achieved, highlighting the versatility of the NHO/TU(U) system. These findings enrich the type of TU/U and base organocatalyst.
Formula: C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem