Month: October 2022

In 1985,Catalan, Javier; Menendez, Margarita; Elguero, Jose published 《On the relationships between basicity and acidity in azoles》.Bulletin de la Societe Chimique de France published the findings.Recommanded Product: 16681-56-4 The information in the text is summarized as follows:

A linear relation between both acidic and basic pKa values is shown for a large collection of imidazoles, benzimidazoles, 1,2,4-triazoles and tetrazoles. Surprisingly, pyrazoles fall on a parallel line, separated from the preceding one by 3.1 pKa units; pyrazoles, and probably 1,2,3-triazoles, are less basic than the other azoles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4Recommanded Product: 16681-56-4)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Research on Chemical Intermediates included an article by Srikrishna, Devulapally; Dubey, Pramod Kumar. Electric Literature of C7H5ClN2. The article was titled 《Synthesis of novel substituted 3-(4-((1H-benzo[d]imidazol-2-ylthio)methyl)-1-phenyl-1H-pyrazol-3-yl)-2H-chromen-2-ones: various approaches》. The information in the text is summarized as follows:

Considering benzimidazole as a privileged structure for developing probes of impressive pharmacol. potentials, some new coumarin and pyrazole conjugates of benzimidazoles I (R = Me, Et, Bn; X = H, OMe) were synthesized with a sulfur linkage. Thus, 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde was prepared starting from simple salicylaldehyde which has been used as an important synthon and incorporated in a series of structural manipulations to obtain various pharmacophoric motif conjugates I (R = H, Me, Et, Bn) in fair yields. A facile and stepwise method has been developed for the synthesis of all these compounds in various approaches, which also involves sub-sequences. In addition to this study using 2-Chloro-1H-benzo[d]imidazole, there are many other studies that have used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Electric Literature of C7H5ClN2) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Electric Literature of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Hogendorf, Adam S.; Hogendorf, Agata; Kurczab, Rafal; Kalinowska-Tluscik, Justyna; Popik, Piotr; Nikiforuk, Agnieszka; Krawczyk, Martyna; Satala, Grzegorz; Lenda, Tomasz; Knutelska, Joanna; Bugno, Ryszard; Staron, Jakub; Pietrus, Wojciech; Matloka, Mikolaj; Dubiel, Krzysztof; Moszczynski-Petkowski, Rafal; Pieczykolan, Jerzy; Wieczorek, Maciej; Pilarski, Boguslaw; Zajdel, Pawel; Bojarski, Andrzej J.. Recommanded Product: 1H-Imidazol-2-amine. The article was titled 《2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design》. The information in the text is summarized as follows:

A new strategy in the design of aminergic GPCR ligands is proposed – the use of aromatic, heterocyclic basic moieties in place of the evergreen piperazine or alicyclic and aliphatic amines. This hypothesis has been tested using a benchmark series of 5-HT6R antagonists obtained by coupling variously substituted 2-aminoimidazole moieties to the well established 1-benzenesulfonyl-1H-indoles, which served as the ligands cores. The crystallog. studies revealed that upon protonation, the 2-aminoimidazole fragment triggers a resonance driven conformational change leading to a form of higher affinity. This mol. switch may be responsible for the observed differences in 5-HT6R activity of the studied chemotypes with different amine-like fragments. Considering the multiple functionalization sites of the embedded guanidine fragment, diverse libraries were constructed, and the relationships between the structure and activity, metabolic stability, and solubility were established. Compounds from the N-(1H-imidazol-2-yl)acylamide chemotype (10a-z) exhibited high affinity for 5-HT6R and very high selectivity over 5-HT1A, 5-HT2A, 5-HT7 and D2 receptors (negligible binding), which was attributed to their very weak basicity. The lead compound in the series 4-methyl-5-[1-(naphthalene-1-sulfonyl)-1H-indol-3-yl]-1H-imidazol-2-amine (9i) was shown to reverse the cognitive impairment caused by the administration of scopolamine in rats indicating procognitive potential. In the experiment, the researchers used 1H-Imidazol-2-amine(cas: 7720-39-0Recommanded Product: 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Recommanded Product: 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Inherited Metabolic Disease included an article by Leon-Del-Rio, Alfonso. Computed Properties of C10H16N2O3S. The article was titled 《Biotin in metabolism, gene expression, and human disease》. The information in the text is summarized as follows:

A review. Biotin is a water-soluble vitamin that belongs to the vitamin B complex and which is an essential nutrient of all living organisms from bacteria to man. In eukaryotic cells biotin functions as a prosthetic group of enzymes, collectively known as biotin-dependent carboxylases that catalyze key reactions in gluconeogenesis, fatty acid synthesis, and amino acid catabolism. Enzyme-bound biotin acts as a vector to transfer a carboxyl group between donor and acceptor mols. during carboxylation reactions. In recent years, evidence has mounted that biotin also regulates gene expression through a mechanism beyond its role as a prosthetic group of carboxylases. These activities may offer a mechanistic background to a developing literature on the action of biotin in neurol. disorders. This review summarizes the role of biotin in activating carboxylases and proposed mechanisms associated with a role in gene expression and in ameliorating neurol. disease. The experimental part of the paper was very detailed, including the reaction process of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Computed Properties of C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Computed Properties of C10H16N2O3S The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903》 were Sharma, Swagat H.; Pablo, Juan Lorenzo; Montesinos, Monica Suarez; Greka, Anna; Hopkins, Corey R.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Safety of 2-Chloro-1H-benzo[d]imidazole The author mentioned the following in the article:

The transient receptor potential cation channel 5 (TRPC5) has been previously shown to affect podocyte survival in the kidney. As such, inhibitors of TRPC5 are interesting candidates for the treatment of chronic kidney disease (CKD). Herein, we report the synthesis and biol. characterization of a series of N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors. Work reported here evaluates the benzimidazole scaffold and substituents resulting in the discovery of I, a TRPC5 inhibitor that is active in multiple animal models of CKD. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Safety of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Safety of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Density, Refractive Index and Volumetric Properties of Water-Ionic Liquid Binary Systems with Imidazolium-Based Cations and Tetrafluoroborate, Triflate and Octylsulfate Anions at T = 293 to 343 K and p = 0.1 MPa》 were Carissimi, Guzman; Montalban, Mercedes G.; Diaz Banos, F. Guillermo; Villora, Gloria. And the article was published in Journal of Chemical & Engineering Data in 2019. Electric Literature of C8H15BF4N2 The author mentioned the following in the article:

The d. and refractive index of ionic liquids (ILs) + water binary mixtures were determined as a function of temperature (from 293.15 to 343.15 K) at atm. pressure over the whole composition range in which the mixtures were miscible. To carry out a systematic study, all of the ILs selected are imidazolium-based ILs with a different number of carbons in the alkyl chain of the cation and also different anions (tetrafluoroborate, triflate, and octylsulfate). Specifically, the studied ILs were 1-ethyl-3-methylimidazolium tetrafluoroborate [emim][BF4], 1-butyl-3-methylimidazolium tetrafluoroborate [bmim][BF4], 1-hexyl-3-methylimidazolium tetrafluoroborate [hmim][BF4], 1-methyl-3-octylimidazolium tetrafluoroborate [omim][BF4], 1-ethyl-3-methylimidazolium triflate [emim][TfO], 1-butyl-3-methylimidazolium triflate [bmim][TfO], and 1-butyl-3-methylimidazolium octylsulfate [bmim][OcSO4]. The excess molar volumes and the deviation in the molar refraction of the binary mixtures were calculated for a better understanding of the interactions that take place between the components and were successfully correlated by the Redlich-Kister empirical correlations. The Bahe-Varela model, which has a more phys. meaning, was also used to successfully correlate the excess molar volume values. Volumetric properties, such as apparent molar volumes, partial molar volumes, isobaric thermal expansion coefficients, partial molar volumes at infinite dilution and excess partial molar volumes at infinite dilution were also calculated in order to obtain information about the influence of composition and temperature on the thermodn. behavior of the selected ILs and water in the mixture The results are discussed in order to understand the formation of hydrogen bonds between components of the mixture and the possible packing effects that take place in the mixing process. The d. and refractive index exptl. data were correlated by the Lorentz-Lorenz, Wiener, Dale-Gladstone, and Eykman equations to determine the relationship between both parameters, and good agreement between the exptl. and calculated refractive index values was obtained. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Electric Literature of C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Electric Literature of C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Espiritu, Adrian I.; Remalante-Rayco, Patricia Pauline M. published their research in Multiple Sclerosis and Related Disorders in 2021. The article was titled 《High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials》.Computed Properties of C10H16N2O3S The article contains the following contents:

Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of ATP (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials. We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials.gov website until Apr. 2021. We considered randomized clin. trials (RCTs) that involved adult patients diagnosed with any phenotype of multiple sclerosis that conforms with the McDonald 2010/2017 criteria or the Lublin 2014 criteria. We included studies employing high-dose biotin or “”MD1003″” administered orally for at least 300 mg/day and given for at least three months. The methodol. quality assessment of the included studies was done using the Cochrane Risk of Bias (RoB) tool. The GRADE approach was used to assess the certainty of evidence [COE]. Out of 366 records identified, three RCTs involving 889 individuals diagnosed with MS (830 participants had progressive MS (PMS); 59 had RRMS) were pooled for analyses. The overall female:male ratio was 1.16:1. All included trials used HDB as an adjunctive treatment. The risks of bias in the three studies were low across the domains. At 12 to 15 mo, there is insufficient evidence that the HDB and placebo arms differed in terms of composite improvement of MS-related disability (relative risk (RR) 2.87; 95% CI 0.29-28.40; 2 trials; 796 participants; I2 = 66%) [low COE], improvement in expanded disability status scale (IEDSS) (RR 2.27; 95% CI 0.25-20.98; 2 trials; 796 participants; I2 = 63%) [low COE], and both IEDSS and improvement in 25-ft walk time (ITW25) (IEDSS-ITW25) (RR 0.58; 95% CI 0.17-2.00; 2 trials; 796 participants; I2 = 13%) [moderate COE] among patients with PMS. Pooled data for ITW25 at 12 to 15 mo yielded statistical significance (RR 2.06; 95% CI 1.04-4.09; 2 trials; 796 participants; I2 = 0%) [moderate COE] favoring HDB among patients with PMS. At 12 to 15 mo, no significant differences were found in terms of mean change in EDSS (MD -0.06; 95% CI -0.14-0.02; 2 studies; 796 participants; 889 participants; I2 = 68%) among patients with PMS. Synthesized data on incidence of any AEs (RR 0.98; 95% CI 0.92-1.04; 3 trials; I2 = 0%) [high COE] and any serious AEs (RR 0.98; 95% CI 0.77-1.24; 3 trials; 889 participants; I2 = 0%) [moderate COE] were not significantly different between HDB and placebo groups. Out of 662 pooled patients in the HDB group, 31 patients (4.7%) were found to have laboratory test interference compared to zero event in the pooled placebo group [high COE]. A moderate certainty of evidence suggests a potential benefit in favor of HDB administered for 12 to 15 mo in terms of ITW25 in patients with PMS. However, an important trade-off of this benefit is the high certainty of evidence suggesting an increased incidence of laboratory test interference when HDB is taken. After reading the article, we found that the author used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Computed Properties of C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Computed Properties of C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kattnig, B. Y. Mladenova; Chumakova, N. A.; Kattnig, D. R.; Grigor’ev, I. A.; Grampp, G.; Kokorin, A. I. published their research in Journal of Physical Chemistry B in 2021. The article was titled 《Influence of electric charge of spin probes on their diffusion in room-temperature ionic liquids》.Recommanded Product: 174501-65-6 The article contains the following contents:

The rotational and translational diffusion of neg. charged and uncharged spin probes in five imidazolium-based room-temperature ionic liquids (RTILs), 1-ethyl-3-methylimidazolium tetrafluoroborate, emimBF4, 1-butyl-3-methylimidazolium tetrafluoroborate, bmimBF4, 1-octyl-3-methylimidazolium tetrafluoroborate, omimBF4, 1-octyl-3-methylimidazolium hexafluorophosphate, omimPF6, and 1-octyl-3-methylimidazolium chloride, omimCl, has been studied by means of ESR spectroscopy. Detailed analyses of the spin-Hamiltonian parameters and spin exchange interactions have been carried out. The temperature dependences of the line broadening induced by the electronic dipole-dipole interaction and the electron spin exchange coupling are determined The translational mobility of spin probes is semiquant. characterized and successfully explained in the framework of a hypothesis based on the assumption of polar and unpolar domains within the RTILs. In the experiment, the researchers used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Recommanded Product: 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Recommanded Product: 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《New expanded-ring NHC platinum(0) complexes: Synthesis, structure and highly efficient diboration of terminal alkenes》 was written by Rzhevskiy, Sergey A.; Topchiy, Maxim A.; Lyssenko, Konstantin A.; Philippova, Anna N.; Belaya, Maria A.; Ageshina, Alexandra A.; Bermeshev, Maxim V.; Nechaev, Mikhail S.; Asachenko, Andrey F.. Recommanded Product: 258278-25-0 And the article was included in Journal of Organometallic Chemistry on April 15 ,2020. The article conveys some information:

The synthesis and structural characterization of novel Pt(0) complexes are reported. A number of (NHC)Pt(dvtms) (dvtms = 1,3-divinyl-1,1,3,3-tetramethyldisiloxane) complexes were studied in catalytic addition of B2Pin2 to terminal alkenes. The novel expanded ring N-heterocyclic carbene complex (7-Dipp)Pt(dvtms) showed highest performance, turnover numbers up to 3800 were achieved. The scope of the reaction was illustrated by 20 examples with a variety of alkyl, alkoxy, halogen, ester, ketone and acetal substituents. In the experiment, the researchers used many compounds, for example, 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Recommanded Product: 258278-25-0)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) may be used as a precursor to the free carbene 1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene, and also used as an in situ formed catalyst in a variety of reactions, e.g. amination, Heck coupling reaction, the ring-opening metathesis polymerization (ROMP), hydrogenation.Recommanded Product: 258278-25-0In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis and the reactions of 2,4,6-tris(ω-hydroxyalkyl)-1,3,5triazines》 was published in Bulletin of the Chemical Society of Japan in 1965. These research results belong to Nohira, Hiroyuki; Nishikawa, Yoshihiro; Furuya, Yoshiaki; Mukaiyama, Teruaki. Product Details of 2403-66-9 The article mentions the following:

From HO(CH2)nCN (I) and HCl were prepared the corresponding cyclic imino ethers HCl salts (II.HCl), which on treatment with Et3N gave the title compounds (III). The reactions of III with o-C6H4-(NH2)2 (IV) and 1,8-naphthalenediamine (V) were investigated. Treatment of Cl(CH2)3OH with KCN in EtOH-H2O (Aksnes and Prue, CA 53, 8004f) gave 30% I (n = 3), b11 1078°. A mixture of 22 g. Cl(CH2)4OH, 33 g. KCN, 50 ml. glycerol, and 25 ml. H2O heated and stirred 15 min. at 100-10°, cooled, and extracted with 4 50-ml. portions tetrahydrofuran (THF) gave 7.0 g. I (n = 4), b0.5 86-8°; when the distillation was carried out without extracting soon after the reaction was complete, almost 30% THF, b. 65-6° was formed as by-product. From Cl(CH2)5OH was similarly prepared 83% I (n = 5), b3 97-8°. Dry HCl passed into 300 ml. dry Et2O containing 8.5 g. I (n = 3) at 10-15° with cooling and the mixture let stand 2 days at room temperature in a stoppered flask gave 11.5 g. II (n = 3) HCl salt, m. 103-5°. Similar treatment of I (n = 4) with HCl but in more dilute (1.5-2.0%) Et2O solution gave 90% II (n = 4) HCl salt, m. 128-9°. Dry HCl passed into 150 ml. dry Et2O and 80 ml. dry glycol acetal-free dioxane containing 4.5 g. I (n = 5) with cooling and the mixture kept 4 days at room temperature, refluxed 3 hrs., and evaporated in vacuo gave 5.1 g. H (n = 5) HCl salt, m. 143-4°. Heating II.HCl 5 min. at 150-60° or refluxing them in PhMe gave the corresponding Cl(CH2)nCONH2 (VI). The following VI were prepared (n, % yield, and m.p. given): 3, 95, 97°; 4, 80, 78°; 5, 95, 102°. II.HCl (0.08 mole) and 16.0 g. Et3N in 80 ml. absolute THF let stand 3 days at room temperature in a stoppered flask with intermittent shaking and the solution filtered and fractionated gave the following III (n, % yield, and b.p./ mm. given): 3, 53, 196-8°/0.1; 4, 70, 207-9°/0.04; 5, 50, 21821°/0.01. III (n = 3) (0.5 g.) and 0.7 g. PhNCO in 10 ml. THF let stand 2 days and evaporated gave 1.1 g. VII, m. 124-5° (95% EtOH). III and 3 mol. equivalents IV or V heated at 220-30° (oil bath) under N evolution of NH3 ceased (15-60 min.) and the mixture cooled and washed with Et2O gave VIII and IX, resp. The following VIII and IX were prepared (n, % yield, and m.p. given): VIII: 3, 85, 160-1° (THF) (O-Ac derivative m. 88-9°); 4, 79, 1645° (THF) (O-Ac derivative m. 95-7°; O,N-di-Ac deriv, m. 68-9°); 5, 55, 106° (EtOAc) (O,N-di-Ac derivative m. 78-9°); IX: 3, 34, 145-6° (dioxane); 4, 45, 157-8° (THF); 5, 60, 185-7° (dioxane). The O-Ac derivatives of VIII were prepared by reaction of VIII and 1.2 mol. equivalents Ac2O in C2H5N at room temperature; the O,N-di-Ac derivatives of VIII were prepared by reaction of VIII and 2.5 mol. equivalents Ac2O in C5H5N at 100% III (n = 3) (0.5 g.) and 0.7 g. V heated 1 hr. at 250-60° (N atm.) and the mixture cooled and washed with Et2O gave 0.5 g. X, m. 143-4° (THF). Ir and uv data were given for III (n = 3, 4, and 5). The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Product Details of 2403-66-9)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Product Details of 2403-66-9 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem