Month: October 2022

《Flammability hazard analysis of imidazolium-based ionic liquid binary mixtures under high temperatures》 was written by Li, Yongheng; Pan, Yong; Huang, Gaosheng; Wang, Qingguo; Wei, Qian; Jiang, Juncheng. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate And the article was included in Journal of Loss Prevention in the Process Industries in 2020. The article conveys some information:

Ionic liquid (IL) mixtures are promising because they can optimize the involved properties according to industrial needs. It has already been demonstrated that IL flammability is due mainly to IL decomposition generating flammable substances. Four different ILs, 1-Butylimidazolium tetrafluoroborate ([BIM][BF4]), 1-butylimidazolium nitrate ([BIM][NO3]), 1-butyl-3-methylimidazolium tetrafluoroborate([BMIM][BF4]), and 1-butyl-3-methylimidazolium nitrate ([BMIM][NO3]), were selected as the parent salts to form the different imidazolium-based IL binary mixtures These mixtures were tested via isothermal thermogravimetric analyzer (TGA) at different temperatures (120, 150, 180, 210, and 240°C), then tested by the flash point analyzer after isothermal heating pretreatment at the above temperatures Results show that the mixtures’ flash point values decrease with the heating temperature increase. Vaporization of the IL mixtures’ decomposition products results in a higher concentration of flammable gases and a flash point decrease, which lead to the flammability hazard increasing. Moreover, results show that the flash points of the studied binary imidazolium IL mixtures are more similar to those of the more unstable IL in their parent ILs. Also, the flammability hazard of IL binary mixtures may obviously increase under the high temperature environment for a long time. In the experiment, the researchers used many compounds, for example, 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mukherjee, Shuvam; Bera, Kaushik; Jana, Subrata; Pal, Saikat; Anand, Namrata; Ray, Bimalendu; Ray, Sayani published an article in 2021. The article was titled 《Conjugation reaction with ferulic acid boosts the antioxidant property of arabinogalactan-protein and enhances its ability to form complex with β-lactoglobulin》, and you may find the article in International Journal of Biological Macromolecules.Related Products of 530-62-1 The information in the text is summarized as follows:

Ferulic acid was chem. grafted onto the arabinogalactan protein of Aegle marmelos fruit gum using 1,1′-carbonyldiimidazole as coupling reagent. Thus, grafted polysaccharides with different degrees of substitution were prepared and then characterized by gas chromatog./mass spectrometry, size exclusion chromatog., and UV-visible, infra-red, and NMR spectroscopic investigations. Fluorescence spectroscopic investigation showed hydrophobic microdomain formation in grafted polymers. The antioxidant activities of the derivatives, as determined by the 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl radical assay, were strong and increases with increasing the degree of feruloylation. Compared to parental arabinogalactan protein (K = 2.38 x 106 M-1), these grafted polymers bind more strongly with β-lactoglobulin (K = 11.4 x 106 M-1 and 8.19 x 106 M-1). Given that gum polysaccharides are valuable component in functional foods, synthesis of antioxidative graft polymer possessing good compatibility with β-lactoglobulin may have important implication. The experimental part of the paper was very detailed, including the reaction process of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Related Products of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2013,Chemical Communications (Cambridge, United Kingdom) included an article by Visbal, Renso; Laguna, Antonio; Gimeno, M. Concepcion. Electric Literature of C27H38AuClN2. The article was titled 《Simple and efficient synthesis of [MCl(NHC)] (M = Au, Ag) complexes》. The information in the text is summarized as follows:

A facile and efficient synthetic route leading to catalytically relevant N-heterocyclic carbene (NHC) gold complexes is described. The method consists of one pot synthesis starting from readily available imidazolium salts and [AuCl(tht)], in the presence of K2CO3. Using the same protocol NHC silver complexes have been synthesized starting from AgNO3. In the experimental materials used by the author, we found Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Electric Literature of C27H38AuClN2)

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Electric Literature of C27H38AuClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Lee, Shao-Chi; Guo, Lin; Rueping, Magnus. Electric Literature of C27H39ClN2. The article was titled 《Nickel-catalyzed exo-selective hydroacylation/Suzuki cross-coupling reaction》. The information in the text is summarized as follows:

The first nickel-catalyzed intramol. hydroacylation/Suzuki cross coupling cascade of phenylboronic acid neopentyl glycol esters I (R = Ph, anthracen-9-yl, thiophen-2-yl, etc.) with a broad range of o-allylbenzaldehydes 2-CH2=CHCH2-4-R3-5-R2-6-R1C6HCHO (R1 = H, R2 = H, OMe; R1R2 = CH=CHCH=CH; R3 = H, OMe, Me, F) has been developed. This strategy shows high regioselectivity and step economy in the construction of two C-C bonds via aldehyde C-H bond activation, affording valuable indanones II with high efficiency. In the experiment, the researchers used 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Electric Literature of C27H39ClN2)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Electric Literature of C27H39ClN2In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Straightforward synthesis of [Au(NHC)X] (NHC = N-heterocyclic carbene, X = Cl, Br, I) complexes》 were Collado, Alba; Gomez-Suarez, Adrian; Martin, Anthony R.; Slawin, Alexandra M. Z.; Nolan, Steven P.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2013. Recommanded Product: 852445-84-2 The author mentioned the following in the article:

An improved protocol for the synthesis of [Au(NHC)X] (X = Cl, Br, I) complexes is reported. This versatile 1-step synthetic methodol. proceeds under mild conditions, in air, using tech. grade solvents, is scalable and is applicable to a wide range of imidazolium and imidazolidinium salts. Optimized conditions include reaction of [Au(SMe2)Cl] with the corresponding 1,3-disubstituted imidazolium or imidazolidinium (NHC).HX salts (same X) in acetone with 1 equiv K2CO3 base for 1 h at 60°, affording 53-97% yields of [Au(NHC)X] complexes. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Recommanded Product: 852445-84-2) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Recommanded Product: 852445-84-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,International Journal of Biological Macromolecules included an article by Noguchi, Seiichiro; Sato, Koki; Yamamoto, Kazuya; Kadokawa, Jun-ichi. Reference of 1-Methyl-1H-imidazole. The article was titled 《Preparation of composite and hollow particles from self-assembled chitin nanofibers by Pickering emulsion polymerization》. The information in the text is summarized as follows:

This study investigated Pickering emulsion polymerization of styrene using self-assembled chitin nanofibers (CNFs) as stabilizers to produce CNF-based composite particles, which were further converted into hollow particles. Previously, we reported that regeneration from a chitin/1-allyl-3-methylimidazolium bromide ion gel using methanol fabricated self-assembled CNFs. Prior to the emulsion polymerization, CNFs were maleylated by reaction with maleic anhydride in the presence of perchloric acid. After styrene was added to a dispersion of the produced anionic CNFs in ammonia aqueous, a mixture was ultorasonicated to give an emulsion, in which styrene droplets were stably surrounded by CNFs. Radical polymerization was then conducted in the presence of potassium persulfate as an initiator to produce the composite particles. Particle sizes became smaller as the amounts of CNFs increased. The hollow particles were prepared by solubilizing out the polystyrene cores with toluene. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Reference of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Reference of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Pareek, Shubhra; Jain, Deepti; Hussain, Shamima; Biswas, Amrita; Shrivastava, Rahul; Parida, Saroj K.; Kisan, Hemanta K.; Lgaz, Hassane; Chung, Ill-Min; Behera, Debasis. Safety of 1H-Benzo[d]imidazol-2-amine. The article was titled 《A new insight into corrosion inhibition mechanism of copper in aerated 3.5 weight% NaCl solution by eco-friendly Imidazopyrimidine Dye: experimental and theoretical approach》. The information in the text is summarized as follows:

A large number of mechanism were anticipated for Cu since 1988 in NaCl medium. The detail electrochem. behavior leading to the anodic dissolution of Cu, however, still remains uncertain. Herein, an Imidazopyrimidine Dye, named, 4-amino-3-(phenyldiazenyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2(1H)-one, (APIP) was used as a Cu corrosion inhibitor in 3.5% (by weight) NaCl solution The present study provides a brief mechanistic overview of the electrochem. mechanism of Cu in aerated NaCl solution, simulating a static marine environment, with and without addition of APIP inhibitor. Potentiodynamic polarization (PDP) results confirmed that the APIP can suppress Cu corrosion effectively at low concentration in 3.5% NaCl solution with an inhibition efficiency of 92.79% due to adsorption, along with the prediction of electrochem. mechanism. Electrochem. impedance spectroscopy (EIS) measurements showed that the corrosion inhibition of Cu proceeds via both diffusion and kinetic controlled processes. Adsorption of APIP on Cu surface is well fit with the Langmuir isotherm model and mode of adsorption is proposed. Antimicrobial activity was also studied and the result obtained showed ”eco-friendly” nature of APIP. Field Emission Scanning Electron Microscope (FE-SEM), Energy dispersion x-ray (EDX) and Attenuated Total Reflectance-FTIR Spectroscopy (ATR-FTIR) observations of the Cu surfaces confirmed the existence of adsorption of APIP thus can be potentially used in industries in which seawater is implied are numerous such as cooling H2O systems, desalination plants, power plants, and oil production units. Results obtained from theor. calculations including quantum chem. d. functional theory (DFT) method and mol. dynamics (MD) simulations confirms the exptl. findings and provide further insight into the mode of adsorption on the Cu surface. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Sheikh, Hamdullah Khadim; Arshad, Tanzila; Habib, Uzma; Mohammad, Zainab Sher; Siddiqui, Maaz Uddin Ahmed; Hassan, Mohtasheemul published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Colorimetric chromophoric rapid detection of SARS-CoV-2 through breath analysis》.Recommanded Product: 7720-39-0 The author mentioned the following in the article:

Early and rapid detection of SARS-CoV-2 in an infected person is one fundamental part of the strategy against the spread of this virus. As of now, the usual practice is to carry out polymerase chain reaction (PCR) test which provides results in 24-48 h. Hence, there exists a crucial need for rapid and immediate screening of people suspected to be infected. Presence of volatile organic compounds (VOCs) in the exhaled breath can be one such prospect for detection of virus. In this paper, we have designed chromophoric adducts of VOC′s in the exhaled breath that can be formed for colorimetric detection of SARS-CoV-2. We noted the bathochromic shift in λ (nm) of VOC mols. upon chromophore formation for colorimetric detection. If adapted, this research work will result in low cost solution to the requirement of immediate detection of SARS-CoV-2, hence cost and time of testing will be reduced, compared to PCR and antibodies tests. Also VOC′s detection in early stage of infection where symptoms are not visible can be advantageous. The experimental part of the paper was very detailed, including the reaction process of 1H-Imidazol-2-amine(cas: 7720-39-0Recommanded Product: 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gupta, Radhey S. published an article on February 27 ,1987. The article was titled 《Identification of 2-benzimidazolylurea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of CHO cells》, and you may find the article in Biochemical and Biophysical Research Communications.Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole The information in the text is summarized as follows:

The cross-resistance patterns of a set of nocodazole  [31430-18-9]-resistant (NocR) and podophyllotoxin  [518-28-5]-resistant (PodR) mutants of Chinese hamster ovary cells, which exhibit highly-specific cross-resistance toward compounds that show nocodazole-like antimitotic activity, towards a large number of benzimidazole derivatives was examined Of the various compounds examined, the NocR and the PodR mutants were found to exhibit increased cross-resistance towards only 2-benzimidazolylurea  [24370-25-0], indicating that this compound may possess similar biol. activity as nocodazole. The nocodazole-like antimitotic activity of 2-benzimidazolylurea was confirmed by its ability to block cells in mitosis, and by its competition of [3H]podophyllotoxin binding to microtubule proteins in cell extracts The nocodazole-like behavior of 2-benzimidazolylurea and lack of similar activity in other benzimidazole derivatives examined, provides valuable information regarding structural features that are required for this type of biol. activity. After reading the article, we found that the author used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Hattori, Yohei; Kitajima, Ryota; Matsuoka, Ryota; Kusamoto, Tetsuro; Nishihara, Hiroshi; Uchida, Kingo. Category: imidazoles-derivatives. The article was titled 《Amplification of luminescence of stable radicals by coordination to NHC-gold(I) complex》. The information in the text is summarized as follows:

Gold NHC pyridine complexes I·SbF6 (R = 2,6-iPr2C6H3, 2,4,6-Me3C6H2, Cy, Me; X = H, X-X = benzo), substituted by stable radical in pyridine 4-position, were prepared and examined for photoluminescence properties. The luminescence of stable radicals can be enhanced by coordination to metal complexes. The 4% fluorescence quantum yield of (3,5-difluoro-4-pyridyl)bis(2,4,6-trichlorophenyl)methyl radical (F2PyBTM) in dichloromethane was enhanced up to 36% by coordination to AuI with N-heterocyclic carbene ligand, which is a record for metal-radical complexes.Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Category: imidazoles-derivatives) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem