Month: October 2022

The author of 《Locating the binding domains of lysozyme with ionic liquids in aqueous solution via spectroscopic studies》 were Guo, Yun; Zhang, Bo; Lu, Chao; Liu, Xiaoxue; Li, Qing; Zhang, Hua; Wang, Zhanzhong. And the article was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2019. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate The author mentioned the following in the article:

The binding domains of lysozyme with ionic liquids (ILs, [C4mim]BF4, [C4mim]Cl, [C4mim]Br and [dmim]I) in aqueous solution was investigated by studying mol. interactions using spectroscopic techniques. UV spectroscopy (UV) showed that the addition of ILs increased the absorption peak intensity of lysozyme at 210 nm by enhancing peptide bond valence electron transition. It is also found that a weak interaction between ILs and lysozyme chromophore groups was generated by analyzing the changes of absorption peak intensity near 280 nm. Fluorescence and Synchronous Fluorescence spectra results showed that four ILs had quenching effect on the fluorescent substances of lysozyme, and the quenching effect rose with increasing ILs concentration Meanwhile, the interaction between lysozyme and ILs mols. is mainly based on Van der Waals force and two Tryptophan (Trp) residues (Trp62 or Trp108) at the active site of lysozyme mols. play a critical role in binding ILs to their own mols. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《””Induced-Fit Suction”” effect: a booster for biofuel storage and separation》 were Li, He; Guo, Fangyuan; Hu, Jun; Peng, Changjun; Wang, Hualin; Liu, Honglai; Li, Jing. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. Recommanded Product: 1H-Benzo[d]imidazol-2-amine The author mentioned the following in the article:

Target-response deformation has provided a wide variety of possibilities for selective mol. separation In this report, both exptl. and theor. methods were used to demonstrate how fine-tuning the amphiphilicity of ZIF-7 can induce an alc.-based target-response deformation. A step-by-step simulation of dynamic adsorption revealed that ZIF-7-NH2 can successfully align alc. mols. to facilitate selective adsorption, while the benzene rings in ZIF-7-NH2 were induced to flip over and maintain the open-gate conformation. As a result, ZIF-7-NH2 with an amino mole ratio of 10% achieved an ideal n-butanol/water selectivity of 40, and also the highest n-butanol uptake of 4.33 mmol g-1 from 5 wt% n-butanol aqueous solution under ambient conditions. Therefore, a new mechanism of “”Induced-Fit Suction”” (IFS) that we propose provides a promising new strategy for biofuel separation After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Preparation of 1-methyl-2,4,5-trinitroimidazole from derivatives of 1-methylimidazole and its oxidation under nitration conditions》 was written by Lian, Peng-Bao; Chen, Jian; Chen, Li-Zhen; Zhao, Chong-Yang; Wang, Jian-Long; Shen, Fen-Fen. Synthetic Route of C4H6N2 And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. The article conveys some information:

1-Methylimidazole, 1-methyl-4-nitroimidazole, 1-methyl-5-nitroimidazole, or 1-methyl-4,5-dinitroimidazole gave a mixture of 1-methyl-4,5-dinitroimidazole and 1-methyl-2,4,5-trinitroimidazole under the volume ratio of HNO3 to H2SO4 of 1:3 at 80° temperature for 2.5 h, and the highest unisolated yield of 1-methyl-2,4,5-trinitroimidazole was 2.4%. 1-Methyl-2,4,5-trinitroimidazole was prepared from 1-methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl-2,5-dinitroimidazole under the same conditions, and the yields were 65, 76, and 82%, resp. However, when the ratio of HNO3 to H2SO4 was 1:5 and reaction was carried out at 120° for 2.5 h, only 1-methyl-4,5-dinitroimidazole was obtained from 1-methylimidazole, 1-methyl-4-nitroimidazole, or 1-methyl- 5-nitroimidazole in yields 43, 64, and 81%, resp. 1-Methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl- 2,5-dinitroimidazole gave 1-methylimidazolidine-2,4,5-trione under the same conditions, the yields were 61, 63, and 65%, resp. Meanwhile, 1-methylimidazolidine-2,4,5-trione was obtained from 1-methyl-2,4,5-trinitroimidazole. Under strong nitration conditions, the nitro group at the C-2 position is a key substituent to promote oxidation of the imidazole ring. The possible reaction mechanism for the formation of 1-methylimidazolidine-2,4,5-trione from 1-methyl-2,4,5-trinitroimidazole is given. The structure of 1-methylimidazolidine-2,4,5-trione was further confirmed by single crystal X-ray diffraction. In the experimental materials used by the author, we found 1-Methyl-1H-imidazole(cas: 616-47-7Synthetic Route of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Synthetic Route of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 1967,Barlin, Gordon B.; Batterham, Thomas J. published 《The proton magnetic resonance spectra of some diazoles, triazoles, and tetrazoles》.Journal of the Chemical Society [Section] B: Physical Organic published the findings.Synthetic Route of C3H3BrN2 The information in the text is summarized as follows:

The N.M.R. spectra of various charged species from 33 azoles have been measured. In N-methyl-imidazoles and -1,2,4-triazoles the sites of protonation have been determined, and the cations appear to be stabilized by amidinium type resonance. Solvent effects are discussed. 27 references.2-Bromo-1H-imidazole(cas: 16681-56-4Synthetic Route of C3H3BrN2) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Synthetic Route of C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Jeyaleela, G. Dayana; Monisha, S. Irudaya; Vimala, J. Rosaline; Immaculate, A. Anitha published 《Isolation of 2-chlorobenzimidazole from Melia dubia leaf extract and its structural characterisation》.International Journal of Pharmacy and Pharmaceutical Sciences published the findings.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:

Objective: Natural products from medicinal plants, either as isolated compounds or as standardized plant extracts exhibit promising source of medicinal activity against various diseases. The aim of the present work was to make an attempt of isolation of bioactive principle and characterization of the isolated compound, from the medicinal plant Melia dubai Methods: The extraction was done by a cold percolation method and the compound was separated and isolated by chromatog. technique such as a thin layer chromatog. (TLC), column chromatog. and high-performance liquid chromatog. (HPLC). The isolated compound was crystallized and the structural characterization of the isolated compound was made using UV-Visible, FT-IR, 1H-NMR, GC-MS and MS techniques which confirmed the structure of the isolated compound Results: The separated and isolated compound was characterized by both phys. and spectral methods like UV-Visible spectroscopy (UV-Visible), Fourier transform IR spectroscopy (FT-IR), Proton NMR Spectroscopy (1H-NMR), Gas chromatog.-mass spectrometry (GC-MS), and Mass spectrometry(MS). Based on the studies, organizational characteristics of one bioactive principle were deciphered. The results revealed that the isolated species is 2-chlorobenzimidazole and it agreed well with the reported value and spectra for 2-chlorobenzimidazole. Conclusion: The above results obtained in this research work clearly indicated the promising occurrence of 2-chlorobenzimidazole in Media dubia plant leaves. The future scope of these studies may guide us to view the biol. activity of the isolated compound In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Ta, Sabyasachi; Das, Sudipta; Ghosh, Milan; Banerjee, Mahuya; Hira, Sumit Kumar; Manna, Partha Pratim; Das, Debasis. Recommanded Product: 1H-Benzo[d]imidazol-2-amine. The article was titled 《A unique benzimidazole-naphthalene hybrid molecule for independent detection of Zn2+ and N-3 ions: Experimental and theoretical investigations》. The information in the text is summarized as follows:

Single crystal X-ray structurally characterized benzimidazole-naphthalene hybrid (NABI) functions as a unique dual analyte sensor that can detect Zn2+ cation and N-3 anion independently. The NABI forms chelate with Zn2+ to inhibit internal charge transfer (ICT) and -CH=N- isomerization resulting chelation enhanced fluorescence (CHEF). On the other hand, the sensing of N-3 is based on formation of supramol. H-bonded rigid assembly. The association constant of NABI for Zn2+ and N-3 ions are 19 × 104 M-1 and 11 × 102 M-1, resp. Corresponding limit of detections (LOD) are 6.85 × 10-8 and 1.82 × 10-7 M, resp. NABI efficiently detects intracellular Zn2+ and N-3 ions with no cytotoxicity on J774A.1cells under fluorescence microscope. DFT studies unlock underlying spectroscopic properties of free NABI and Zn2+/N-3 bound forms. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota.》 were Sabui, Subrata; Skupsky, Jonathan; Kapadia, Rubina; Cogburn, Kyle; Lambrecht, Nils W; Agrawal, Anshu; Said, Hamid M. And the article was published in American journal of physiology. Gastrointestinal and liver physiology in 2019. Recommanded Product: 58-85-5 The author mentioned the following in the article:

The sodium-dependent multivitamin transporter (SMVT; SLC5A6) is involved in intestinal absorption of vitamin B7 (biotin). We have previously shown that mice with an embryonic intestinal-specific SMVT knockout (KO) develop biotin deficiency and severe spontaneous intestinal inflammation in addition to growth retardation, developmental delays, and death within the first 6-7 wk of life. The profound morbidity and mortality associated with the SMVT-KO has limited our ability to further characterize the intestinal inflammation and other sequelae of this deletion in adult mice with a mature gut microbiota. To overcome this limitation, we generated an intestine-specific, tamoxifen-inducible, conditional SMVT-KO (SMVT-icKO). Our results showed that adult SMVT-icKO mice have reduced body weight, biotin deficiency, shorter colonic length, and bloody diarrhea compared with age- and sex-matched control littermates. All SMVT-icKO mice also developed spontaneous intestinal inflammation associated with induction of calprotectin (S100a8/S100a9), proinflammatory cytokines (IL-1β, TNF-α, IFN-γ, and IL-6), and an increase in intestinal permeability. Additionally, the intestines of SMVT-icKO showed activation of the NF-κB pathway and the nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome. Notably, administration of broad-spectrum antibiotics reduced lethality and led to normalization of intestinal inflammation, proinflammatory cytokines, altered mucosal integrity, and reduced expression of the NLRP3 inflammasome. Overall, these findings support our conclusion that the biotin transport pathway plays an important role in the maintenance of intestinal homeostasis, and that NF-κB and the NLRP3 inflammasome, as well as gut microbiota, drive the development of intestinal inflammation when SMVT is absent.NEW & NOTEWORTHY This study demonstrates that deletion of the intestinal biotin uptake system in adult mice leads to the development of spontaneous gut inflammation and that luminal microbiota plays a role in its development. In the experiment, the researchers used many compounds, for example, 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Recommanded Product: 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Recommanded Product: 58-85-5 And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Detection of miRNAs by tissue printing and dot blot hybridization》 were Nunez, Marcelino Martinez; de Folter, Stefan; de Fatima Rosas-Cardenas, Flor. And the article was published in Methods in Molecular Biology (New York, NY, United States) in 2019. Application of 616-47-7 The author mentioned the following in the article:

Tissue printing and dot blot are simple techniques to detect miRNA expression and localization, allowing a better understanding of the function of a miRNA. The authors describe a tissue printing and a dot blot hybridization protocol for miRNA detection and localization in plant tissues, which opens the possibility of analyzing spatiotemporal expression patterns of miRNAs. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Application of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Application of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis and biological evaluation of some novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids as potential antifungal agents》 was published in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. These research results belong to Perez, Ser John Lynon P.; Atayde, Eduardo C. Jr.; Arco, Susan D.. Name: 1-Methyl-1H-imidazole The article mentions the following:

In an effort to discover lead compounds that may be of importance as potent antifungal agents, a series of novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids were efficiently synthesized through a solvent-free ultrasound-assisted quaternization reaction of 1-methylimidazole and alkyl bromides RBr (R = hexyl, octyl) followed by an anion exchange process with selected carboxylate anions (cinnamate, salicylate, crotonate, and oxalate). Quant. yields obtained were in the range of 86-94%. Structure characterization was done using FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. All the synthesized compounds showed in vitro antifungal activity against the fungus Candida albicans with the min. inhibitory concentrations found to be less than or equal to 1%. Preliminary cytotoxicity assays (trypan blue exclusion and MTT) were performed on all ionic liquids and findings revealed higher lymphocyte viability in 1-hexyl-3-methylimidazolium carboxylate ionic liquids than in 1-octyl-3-methylimidazolium counterparts. No extensive toxicity effect was observed with the carboxylate anion variation. Among the tested compounds, 1-hexyl-3-methylimidazolium crotonate and 1-hexyl-3-methylimidazolium oxalate exhibited the lowest cytotoxicity in the trypan blue exclusion and MTT assays, resp. Together, our results highlight the potential of carboxylate-based ionic liquids in the development of next-generation antifungal drugs. In the experiment, the researchers used 1-Methyl-1H-imidazole(cas: 616-47-7Name: 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Name: 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2021 ,《4H-Chromenes as 1,3-bielectrophiles in the reaction with 2-aminobenzimidazole: synthesis of pyrimido[1,2-a]benzimidazoles》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Osyanin, Vitaly A.; Osipov, Dmitry V.; Korzhenko, Kirill S.; Demidov, Oleg P.; Klimochkin, Yuri N.. The article conveys some information:

A method for the preparation of pyrimido[1,2-a]benzimidazoles containing a 2-hydroxybenzyl or (2-hydroxynaphthalen-1-yl)methyl group at position 3 was proposed based on the reaction of β-carbonyl-substituted 4H-chromenes and their benzo analogs with 2-aminobenzimidazole. In the case of chromenes substituted in the methylene fragment, 7,13a-dihydro-5H-benzo[5′,6′]chromeno-[3′,2′:5,6]pyrimido[1,2-a]benzimidazoles were isolated. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem