Month: October 2022

Ford, Jodi L; Browning, Christopher R published the artcile< Effects of exposure to violence with a weapon during adolescence on adult hypertension.>, HPLC of Formula: 1003-21-0, the main research area is Adverse childhood experiences; Exposure to violence; Hypertension; Victimization; Witnessed violence.

OBJECTIVES: To examine the longitudinal associations between exposure to violence with a weapon during the past year among adolescents and hypertension during adulthood, including the extent to which adult cardiovascular risk factors mediated the association. METHODS: Secondary analysis of the National Longitudinal Study of Adolescent Health, 1994-2008. The sample included 3555 male and 4416 female participants who were aged 11-17 years at wave 1 (1994-1995). Participants were categorized as hypertensive if they had a mean systolic blood pressure of 140 mm Hg or higher or a mean diastolic pressure of 90 mm Hg or higher at wave 4 (2008). Witnessed violence with a weapon was defined as having seen a shooting or stabbing during the year before wave 1, whereas victim of violence with a weapon was defined as having been shot, cut, or stabbed or had a gun or knife drawn on them during the year before wave 1. Potential mediators of adult cardiovascular risk (wave 4) included body mass index, daily smoking, alcohol abuse, and depression. RESULTS: Males who witnessed violence and females who were victims of violence in the year before wave 1 had an increased odds of hypertension at wave 4 compared with their unexposed peers (adjusted odds ratio, 1.45; 95% confidence interval, 1.003-2.10 and adjusted odds ratio, 1.72; 95% confidence interval, 1.04-2.84, respectively). The hypothesized adult cardiovascular risk mediators did not significantly attenuate the associations for either the male or female samples. CONCLUSIONS: Interventions addressing prior violence exposure are needed to promote adult cardiovascular health.

Annals of epidemiology published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Grob, Jonathan E.; Nunez, Jill; Dechantsreiter, Michael A.; Hamann, Lawrence G. published the artcile< One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format>, Related Products of 1003-21-0, the main research area is arylmethylpyrrolidinylmethanol amine derivative preparation; aryl MIDA boronate preparation aryl halide amination Suzuki reaction; boronic acid MIDA.

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MIDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike mols.

Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Murao, Atsushi; Tan, Chuyi; Jha, Alok; Wang, Ping; Aziz, Monowar published the artcile< Exosome-mediated eCIRP release from macrophages to induce inflammation in sepsis>, Application In Synthesis of 6823-69-4, the main research area is inflammation sepsis exosome extracellular cold inducible RNA binding protein; cytokines; eCIRP; exosomes; macrophage; neutrophil; sepsis.

Extracellular cold-inducible RNA-binding protein (eCIRP) is an important damage-associated mol. pattern (DAMP). Despite our understanding of the potentially harmful effects of eCIRP in sepsis, how eCIRP is released from cells remains elusive. Exosomes are endosome-derived extracellular vesicles, which carry proteins, lipids, and nucleic acids to facilitate intercellular communication and several extracellular functions. We hypothesized that eCIRP is released via exosomes to induce inflammation in sepsis. Exosomes isolated from the supernatants of LPS-treated macrophage culture and serum of endotoxemia and polymicrobial sepsis mice showed high purity, as revealed by their unique median sizes ranging between 70 and 126 nm in diameter eCIRP levels of the exosomes were significantly increased after LPS treatment in the supernatants of macrophage culture, mouse serum, and cecal ligation and puncture (CLP)-induced sepsis mouse serum. Protease protection assay demonstrated the majority of eCIRP was present on the surface of exosomes. Treatment of WT macrophages and mice with exosomes isolated from LPS-treated WT mice serum increased TNFα and IL-6 production However, treatment with CIRP-/- mice serum exosomes significantly decreased these levels compared with WT exosome-treated conditions. CIRP-/- mice serum exosomes significantly decreased neutrophil migration in vitro compared with WT exosomes. Treatment of mice with serum exosomes isolated from CIRP-/- mice significantly reduced neutrophil infiltration into the peritoneal cavity. Our data suggest that eCIRP can be released via exosomes to induce cytokine production and neutrophil migration. Thus, exosomal eCIRP could be a potential target to inhibit inflammation.

Frontiers in Pharmacology published new progress about Binding energy. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Application In Synthesis of 6823-69-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rizzo, Carla; Marullo, Salvatore; Feroci, Marta; Accurso, Vincenza; D’Anna, Francesca published the artcile< Insights into the effect of the spacer on the properties of imidazolium based AIE luminogens>, Category: imidazoles-derivatives, the main research area is imidazolium based aggregation induced emission luminogen preparation self assembly.

With the aim to obtain organic salts with potential applications in high performance mol. electronics, we combined properties of π-conjugated spacers, like 1,4-diethynylbenzene and 1,6-diethynylpyrene, with the ones of both imidazole and imidazolium units. Physico-chem. properties of obtained fluorescent organic salts were investigated performing thermo-gravimetric anal. (TGA), differential scanning calorimetry (DSC) and cyclic voltammetry measurements (CV). Photophys. behavior of the salts was analyzed in conventional solvents and ionic liquids, by UV-vis and fluorescence investigation. Solution phase aggregation study revealed that these salts self-assemble in conventional solvents and ionic liquids, leading to aggregation induced emission processes. Notably, emission was maintained also in the solid state, with higher or lower intensity compared with the solution, depending on which spacer is present. This latter, also impacts on the morphol. of the aggregates, allowing fine tuning the properties of the supramol. materials formed.

Dyes and Pigments published new progress about Aggregation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Malina, Jaroslav; Kostrhunova, Hana; Scott, Peter; Brabec, Viktor published the artcile< FeII Metallohelices Stabilize DNA G-Quadruplexes and Downregulate the Expression of G-Quadruplex-Regulated Oncogenes>, Recommanded Product: 7H-Purin-2-amine, the main research area is Fe Metallohelices DNA G quadruplexes oncogenes; DNA; G-quadruplexes; metalo-supramolecular helicates; multitargeted agens; oncogenes.

DNA G-quadruplexes (G4s) have been identified within the promoter regions of many proto-oncogenes. Thus, G4s represent attractive targets for cancer therapy, and the design and development of new drugs as G4 binders is a very active field of medicinal chem. Here, mol. biophysics and biol. methods were employed to investigate the interaction of chiral metallohelices with a series of four DNA G4s (hTelo, c-myc, c-kit1, c-kit2) that are formed by the human telomeric sequence (hTelo) and in the promoter regions of c-MYC and c-KIT proto-oncogenes. We show that the investigated water-compatible, optically pure metallohelices, which are made by self-assembly of simple nonpeptidic organic components around FeII ions and exhibit bioactivity emulating the natural systems, bind with high affinity to G4 DNA and much lower affinity to duplex DNA. Notably, both enantiomers of a metallohelix containing a m-xylenyl bridge (5 b) were found to effectively inhibit primer elongation catalyzed by Taq DNA polymerase by stabilizing G4 structures formed in the template strands containing c-myc and c-kit2 G4-forming sequences. Moreover, both enantiomers of 5 b downregulated the expression of c-MYC and c-KIT oncogenes in human embryonic kidney cells at mRNA and protein levels. As metallohelices also bind alternative nucleic acid structures, they hold promise as potential multitargeted drugs.

Chemistry – A European Journal published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (c-kit1). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Recommanded Product: 7H-Purin-2-amine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xu, Feng; Zhong, Jia-Yu; Lin, Xiao; Shan, Su-Kang; Guo, Bei; Zheng, Ming-Hui; Wang, Yi; Li, Fuxingzi; Cui, Rong-Rong; Wu, Feng; Zhou, En; Liao, Xiao-Bo; Liu, You-Shuo; Yuan, Ling-Qing published the artcile< Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner>, Category: imidazoles-derivatives, the main research area is melatonin vascular calcification ageing paracrine manner exosomal miR cluster; BMP2; ageing; exosomes; melatonin; miR-204/miR-211; vascular calcification.

In the elderly with atherosclerosis, hypertension and diabetes, vascular calcification and ageing are ubiquitous. Melatonin (MT) has been demonstrated to impact the cardiovascular system. In this study, we have shown that MT alleviates vascular calcification and ageing, and the underlying mechanism involved. We found that both osteogenic differentiation and senescence of vascular smooth muscle cells (VSMCs) were attenuated by MT in a MT membrane receptor-dependent manner. Moreover, exosomes isolated from VSMCs or calcifying vascular smooth muscle cells (CVSMCs) treated with MT could be uptaken by VSMCs and attenuated the osteogenic differentiation and senescence of VSMCs or CVSMCs, resp. Moreover, we used conditional medium from MT-treated VSMCs and Transwell assay to confirm exosomes secreted by MT-treated VSMCs attenuated the osteogenic differentiation and senescence of VSMCs through paracrine mechanism. We also found exosomal miR-204/miR-211 mediated the paracrine effect of exosomes secreted by VSMCs. A potential target of these two miRs was revealed to be BMP2. Furthermore, treatment of MT alleviated vascular calcification and ageing in 5/6-nephrectomy plus high-phosphate diet-treated (5/6 NTP) mice, while these effects were partially reversed by GW4869. Exosomes derived from MT-treated VSMCs were internalised into mouse artery detected by in vivo fluorescence image, and these exosomes reduced vascular calcification and ageing of 5/6 NTP mice, but both effects were largely abolished by inhibition of exosomal miR-204 or miR-211. In summary, our present study revealed that exosomes from MT-treated VSMCs could attenuate vascular calcification and ageing in a paracrine manner through an exosomal miR-204/miR-211.

Journal of Pineal Research published new progress about Aging, animal. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ouzon-Shubeita, Hala; Schmaltz, Lillian F.; Lee, Seongmin published the artcile< Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4>, SDS of cas: 452-06-2, the main research area is methyl CpG binding domain 4 DNA base excision repair; DNA glycosylase; base excision repair; substrate recognition.

G:T mismatches, the major mispairs generated during DNA metabolism, are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-binding domain 4 (MBD4) and thymine DNA glycosylase (TDG). Mismatch-specific DNA glycosylases must discriminate the mismatches against million-fold excess correct base pairs. MBD4 efficiently removes thymine opposite guanine but not opposite adenine. Previous studies have revealed that the substrate thymine is flipped out and enters the catalytic site of the enzyme, while the estranged guanine is stabilized by Arg468 of MBD4. To gain further insights into the mismatch discrimination mechanism of MBD4, we assessed the glycosylase activity of MBD4 toward various base pairs. In addition, we determined a crystal structure of MBD4 bound to T:O6-methylguanine-containing DNA, which suggests the O6 and N2 of purine and the O4 of pyrimidine are required to be a substrate for MBD4. To understand the role of the Arg468 finger in catalysis, we evaluated the glycosylase activity of MBD4 mutants, which revealed the guanidinium moiety of Arg468 may play an important role in catalysis. D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine. Comparison of various DNA glycosylase structures implies the guanidinium and amine moieties of Arg and Lys, resp., may involve in discriminating between substrate mismatches and nonsubstrate base pairs.

Biochemical Journal published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (MBD4). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, SDS of cas: 452-06-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Yi; Zhou, Cuihan; Jiang, Meijing; Arndtsen, Bruce A. published the artcile< Versatile Palladium-Catalyzed Approach to Acyl Fluorides and Carbonylations by Combining Visible Light- and Ligand-Driven Operations>, Formula: C4H5BrN2, the main research area is acyl fluoride preparation; acyl halide carbon monoxide photochem carbonylation palladium catalyst.

The development of a general palladium-catalyzed carbonylative method to synthesize acyl fluorides RC(O)F (R = n-Bu, cyclohexyl, 4-methylphenyl, pyridin-3-yl, etc.) from aryl, heteroaryl, alkyl, and functionalized organic halides RX was described. Mechanistic anal. suggests that the reaction proceeds via the unique, synergistic combination of visible light photoexcitation of Pd(0) to induce oxidative addition with a ligand-favored reductive elimination. These together create a unidirectional catalytic cycle that is uninhibited by the classical effect of carbon monoxide coordination. Coupling the catalytic formation of acyl fluorides with their subsequent nucleophilic reactions has opened a method to perform carbonylation reactions with unprecedented breadth, including the assembly of highly functionalized carbonyl-containing products.

Journal of the American Chemical Society published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Subramani, Vinod Kumar; Ravichandran, Subramaniyam; Bansal, Varun; Kim, Kyeong Kyu published the artcile< Chemical-induced formation of BZ-junction with base extrusion>, Recommanded Product: 7H-Purin-2-amine, the main research area is spermine ethanol methanol cobalt sodium perchlorate; 2-Aminopurine; BZ-Junction; Base-extrusion; Z-DNA; Z-DNA junction; Z-inducer.

The crystal structure of BZ-junction reveals that left-handed Z-DNA stabilized by Z-DNA binding domain (Zα) is continuously stacked to right-handed B-DNA with AT bases’ extrusion in the junction site. However, this structure might not fully represent the BZ-junction in solution due to the possibility of the junction formation either by crystal packing or Zα interaction. Therefore, we investigated BZ-junction in solution with chem. Z-DNA inducers using CD and 2-aminopurine base-extrusion assay. We confirmed the formation of Z-DNA and BZ-junction with base-extrusion by chem. Z-DNA inducers. However, neither typical Z-DNA nor base-extrusion could be detected with some inducers such as spermine, suggesting that the energy barrier for the formation of the BZ junction might vary depending on the Z-DNA induction conditions.

Biochemical and Biophysical Research Communications published new progress about Crystal structure. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Recommanded Product: 7H-Purin-2-amine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kerche, Eduardo Fischer; da Silva, Vinicius Demetrio; da Silveira Jankee, Gabriela; Schrekker, Henri Stephan; de Avila Delucis, Rafael; Irulappasamy, Siva; Amico, Sandro Campos published the artcile< Aramid pulp treated with imidazolium ionic liquids as a filler in rigid polyurethane bio-foams>, Reference of 700370-07-6, the main research area is aramid pulp imidazolium ionic liquid filler polyurethane biofoam.

This article reports an aramid pulp (AP) treated with two ionic liquids (IL), namely 1-n-butyl-3-methylimidazolium chloride (C4.Cl) and 1-carboxymethyl-3-methylimidazolium chloride (HO2C), and its use as a filler in reinforced rigid polyurethane foams (RPUF). The RPUF were incorporated with the treated AP at three weight fractions (c.a. 0.1, 0.5, and 1.0 wt%) and were produced by the free rising method. The results showed that the studied IL promoted a better interaction between the AP and the RPUF system, which increased the overall reactivity, imparting a higher cell anisotropy. This also yielded a pos. effect in mech. properties and thermal stability of the RPUF. Compared to the neat RPUF, outstanding increases of approx. 50 and 20% were achieved in compressive modulus and strength, resp. In all, the use of IL promoted increased compatibility between matrix and reinforcement, especially that HO2C IL.

Journal of Applied Polymer Science published new progress about Anisotropy. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Reference of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem