Month: October 2022

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. SDS of cas: 10111-08-7.

Li, Mingmin;Qiao, Shan;Zheng, Yunlong;Andaloussi, Yassin H.;Li, Xia;Zhang, Zhenjie;Li, Ang;Cheng, Peng;Ma, Shengqian;Chen, Yao research published 《 Fabricating Covalent Organic Framework Capsules with Commodious Microenvironment for Enzymes》, the research content is summarized as follows. Enzyme immobilization has been demonstrated to be a favorable protocol to promote industrialization of biomacromols. Despite tremendous efforts to develop new strategies and materials to realize this process, maintaining enzyme activity is still a formidable challenge. Herein we created a sacrificial templating method, using metal-organic frameworks (MOFs) as sacrificial templates to construct hollow covalent organic framework (COF) capsules for enzyme encapsulation. This strategy can provide a capacious microenvironment to unleash enzyme mols. The improved conformational freedom of enzymes, enhanced mass transfer, and protective effect against the external environment ultimately boosted the enzymic activities. We also found that this strategy possesses high versatility that is suitable for diverse biomacromols., MOF templates, and COF capsules. Moreover, the dimensions, pore sizes, and shell thickness of COF capsules can be conveniently tuned, allowing for customizing bioreactors for specific functions. For example, coencapsulation of different enzymes with synergistic functions were successfully demonstrated using this bioreactor platform. This study not only opens up a new avenue to overcome the present limitations of enzymic immobilization in porous matrixes but also provides new opportunities for construction of biomicrodevices or artificial organelles based on crystalline porous materials.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., SDS of cas: 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Application In Synthesis of 3034-50-2.

Li, Mengyuan;Sheth, Sujitraj;Xu, Yalan;Song, Qijun research published 《 Ru(II)-bipyridine complex as a highly sensitive luminescent probe for Cu²⁺ detection and cell imaging》, the research content is summarized as follows. A novel ruthenium(II) polypyridine complex with an imidazole group linked with a conjugated structure has been synthesized and functioned as a novel luminescent probe for the quick and accurate detection of Cu²⁺. The coordination with Cu²⁺ resulted into the formation of stable cyclic structure which leads to luminescence quenching of RuL at the 621 nm. Under the optimal conditions, the linear concentration range was obtained from 0.25-12.0 microM and the corresponding detection limits were calculated to be 83.3 nM (S/N = 3) which is far lower than prescribed permissible limit by World Health Organization. The developed RuL luminescent probe has been applied for the detection of Cu²⁺ in environmental water sample successfully. Furthermore, the RuL probe applied in the cell imaging for detection of Cu²⁺, indicating its suitability for application in vivo. Thus, a simple and quick method has been established with high sensitivity and specificity for the detection of Cu²⁺.

Application In Synthesis of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. HPLC of Formula: 10111-08-7.

Li, Mengwen;Ao, Shen;Liang, Yueqi;Hao, Zhen;Hao, Xiaohui;Liu, Xueliang;Sun, Xinchao;Yang, Yunxu research published 《 The selective and sensitive detection of formaldehyde by ZIF-90-LWvia aza-Cope rearrangement》, the research content is summarized as follows. Formaldehyde (FA), as one of the simplest reactive carbonyl species (RCS), is widely known as an environmental toxin and carcinogen. In this work, a new ZIF-90 type material (ZIF-90-LW) was synthesized and investigated, which combines the two strategies of “2-aza-Cope rearrangement” and “MOF structure”, by the combination of a pre-functionalized 2-allylaminoimidazole ligand and Zn²⁺ salt under solvothermal conditions. From this, the hurdle of selectivity over other carbonyl compounds (RCS) could be overcome despite their similar electrophilic reactivities to FA, and a prominent fluorescence turn-on type signal was realized through the 2-aza-Cope rearrangement mechanism. A good linear relationship (R2 = 0.9979) was obtained by fitting the fluorescence intensity towards FA from 0 to 25 mM, and the detection limit of ZIF-90-LW for FA was 2.3 μM. In addition, it also showed potentially useful sensing ability for the detection of FA in the gas phase, and might therefore be used to rapidly detect FA with a response time of 28 s in the liquid phase. All of the above features clearly demonstrate that ZIF-90-LW has great potential for sensitive and selective recognition of FA in the environment.

HPLC of Formula: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Li, Mengde;Liu, Junjie;Deng, Shuping;Liu, Qian;Qi, Ning;Chen, Zhiquan research published 《 Low-pressure CO₂ capture in zeolite imidazole frameworks with ultramicropores studied by positron annihilation》, the research content is summarized as follows. In this paper, three kinds of zeolite imidazole frameworks (ZIF-90, ZIF-93, and ZIF-94) were synthesized through hydrothermal reactions. Positron lifetime results reveal two kinds of pores corresponding to the channel in the windows and central cavity of ZIFs. The average diameters of the cavities are 1.12, 1.54, and 0.80 nm in ZIF-90, ZIF-93, and ZIF-94, resp., while the average diameters of channels are between 0.55 and 0.60 nm. CO₂ adsorption results show that ZIF-90 has the highest CO₂ adsorption capacities (64.4 cm³ g^-1 at 298 K and 104.7 cm³ g^-1 at 273 K) at 1 bar, followed by ZIF-94 (57.9 cm³ g^-1 at 298 K and 79.4 cm³ g^-1 at 273 K) and ZIF-93 (41.5 cm³ g^-1 at 298 K and 62.5 cm³ g^-1 at 273 K). This shows inconsistency with the total pore volume but is in good agreement with relative volumes of pores smaller than 1.2 nm, which are 6.55, 2.06, and 5.60% for ZIF-90, ZIF-93, and ZIF-94, resp. Further investigation reveals that an even smaller pore size is required for CO₂ adsorption under ultralow pressure. At a pressure of 0.1 bar, ZIF-94 exhibits an ultrahigh CO₂ adsorption capacity (21.2 cm³ g^-1 at 298 K and 32.1 cm³ g^-1 at 273 K) compared with ZIF-93 (10.1 cm³ g^-1 at 298 K and 14.9 cm³ g^-1 at 273 K) and ZIF-90 (5.9 cm³ g^-1 at 298 K and 11.6 cm³ g^-1 at 273 K). These quantities coincide well with the relative volumes of pores smaller than 0.8 nm, which are 5.60, 2.06, and 1.18% for ZIF-94, ZIF-93, and ZIF-90, resp. Our results demonstrate that at atm. pressure, CO₂ mols. are more effectively captured by micropores, while at extremely low pressures, CO₂ mols. are mainly enriched around ultramicropores such as the channels and small cavities in ZIFs.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Recommanded Product: 1H-Imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Formula: C4H4N2O.

Li, Jun;Weng, Yingwei;Shen, Can;Luo, Jiao;Yu, Donghong;Cao, Zhong research published 《 Sensitive fluorescence and visual detection of organophosphorus pesticides with a Ru(bpy)₃²⁺-ZIF-90-MnO₂ sensing platform》, the research content is summarized as follows. Fluorescence sensing organophosphorus pesticides (OPs) is of great importance for both food safety and global environment; however, the reported fluorescent probes are usually directly exposed to the external environment, resulting in premature leakage or photobleaching and thus limiting their photostability and assay sensitivity. In this work, a fluorescent sensing platform consisting of a novel luminescent metal-organic framework (Ru(bpy)₃²⁺-ZIF-90) and manganese dioxide nanosheets (MnO₂ NSs) was prepared for sensing OPs. Due to the protection and improvement in the fluorescence of Ru(bpy)₃²⁺ by ZIF-90, the Ru(bpy)₃²⁺-ZIF-90 probe displayed remarkable photostability and high stability in water. By virtue of the high stability of Ru(bpy)₃²⁺-ZIF-90, as well as the outstanding fluorescence quenching and notable recognition ability of the MnO₂ NSs, this sensing platform provided excellent detection capability for parathion-Me, with a wide concentration range of 0.050-60 ng mL^-1 and a low detection limit of 0.037 ng mL^-1. Addnl., the system exhibited a visual color change with the concentration of the OPs under sunlight. Moreover, satisfactory recoveries ranging from 93.3% to 103.6% were obtained for the real samples. The results indicated that the Ru(bpy)₃²⁺-ZIF-90-MnO₂-based OP sensing platform is promising for applications in food safety and environmental monitoring.

Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 10111-08-7.

Li, Jingyao;Di Lorenzo, Vincenzo;Patil, Pravin;Ruiz-Moreno, Angel J.;Kurpiewska, Katarzyna;Kalinowska-Tluscik, Justyna;Velasco-Velazquez, Marco A.;Doemling, Alexander research published 《 Scaffolding-Induced Property Modulation of Chemical Space》, the research content is summarized as follows. Tetrazole- and heterocycle-containing amino alcs. were prepared by Ugi reactions; the amino alcs. underwent cyclization reactions with carbonyl-, thiocarbonyl-, and sulfonyldiimidazole to yield cyclized products, including benzoxazinones and benzoxazepanones, such as I. Two pyrrole- and imidazole-containing amines were also prepared using Ugi reactions; cyclization reactions with carbonyldiimidazole yielded fused imidazolidinones. The properties (lipophilicity, polar surface area, mol. shape) of virtual libraries of uncyclized and cyclized products were compared. The structures of five of the cyclized products were determined by X-ray crystallog.

Synthetic Route of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Synthetic Route of 250285-32-6.

Li, Jiayi;Wang, Liding;Zhao, Zifeng;Li, Xiaoyue;Yu, Xiao;Huo, Peihao;Jin, Qionghua;Liu, Zhiwei;Bian, Zuqiang;Huang, Chunhui research published 《 Two-Coordinate Copper(I)/NHC Complexes: Dual Emission Properties and Ultralong Room-Temperature Phosphorescence》, the research content is summarized as follows. As a kind of photoluminescent material, Cu^I complexes have many advantages such as adjustable emission, variable structures, and low cost, attracting attention in many fields. In this work, two novel two-coordinate Cu^I-N-heterocyclic carbene complexes were synthesized, and they exhibit unique dual emission properties, fluorescence and phosphorescence. The crystal structure, packing mode, and photophys. properties under different conditions were systematically studied, proving the emissive mechanism to be the locally excited state of the carbazole group. Based on this mechanism, ultralong room-temperature phosphorescence (RTP) with a lifetime of 140 ms is achieved by selective deuteration of the carbazole group. These results deepen the understanding of the luminescence mechanism and design strategy for two-coordinate Cu^I complexes, and prove their potential in applications as ultralong RTP materials.

Synthetic Route of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Reference of 60-56-0.

Li, Jianhua;Hussain, Zahir;Zhu, Junjie;Lei, Saifei;Lu, Jie;Ma, Xiaochao research published 《 Role of CYP2A6 in Methimazole Bioactivation and Hepatotoxicity》, the research content is summarized as follows. Methimazole (MMI) is a widely used antithyroid drug, but it can cause hepatotoxicity by unknown mechanisms. Previous studies showed that the hepatic metabolism of MMI produces N-methylthiourea, leading to liver damage. However, the specific enzyme responsible for the production of the toxic metabolite N-methylthiourea is still unclear. In this study, we screened cytochromes P 450 (CYPs) in N-methylthiourea production from MMI. CYP2A6 was identified as the key enzyme in catalyzing MMI metabolism to produce N-methylthiourea. When mice were pretreated with a CYP2A6 inhibitor, formation of N-methylthiourea from MMI was remarkably reduced. Consistently, the CYP2A6 inhibitor prevented MMI-induced hepatotoxicity. These results demonstrated that CYP2A6 is essential in MMI bioactivation and hepatotoxicity.

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Reference of 60-56-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Related Products of 60-56-0.

Li, Fen-Fen;Zhao, Wen-Hao;Tangadanchu, Vijai Kumar Reddy;Meng, Jiang-Ping;Zhou, Cheng-He research published 《 Discovery of novel phenylhydrazone-based oxindole-thiolazoles as potent antibacterial agents toward Pseudomonas aeruginosa》, the research content is summarized as follows. With the soaring of bacterial infection and drug resistance, it is imperative to exploit new efficient antibacterial agents. This work constructed a series of unique phenylhydrazone-based oxindole-thiolazoles to combat monstrous bacterial resistance. Some target mols. showed potent antibacterial activity, among which oxindole-thiolimidazole derived carboxyphenylhydrazone 4e exhibited an 8-fold stronger inhibitory ability than norfloxacin on the growth of P. aeruginosa, with MIC value of 1 μg/mL. Compound 4e with imperceptible hemolysis could hamper bacterial biofilm formation and significantly impede the development of bacterial resistance. Subsequent mechanism studies demonstrated that 4e could destruct bacterial cytoplasmic membrane, causing the leakage of cellular contents (protein and nucleic acid). Moreover, metabolic stagnation and intracellular oxidative stress caused by 4e expedited the death of bacteria. Furthermore, mol. 4e existed supramol. interactions with DNA to block DNA proliferation. These research results provided a promising light for phenylhydrazone-based oxindole-thiolazoles as novel potential antibacterial agents.

Related Products of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Li, Dazhi;Ollevier, Thierry research published 《 Mechanism studies of oxidation and hydrolysis of Cu(I)-NHC and Ag-NHC in solution under air》, the research content is summarized as follows. The decomposition of copper(I)-NHC and silver-NHC complexes in solution under air was studied. The Cu(I)-NHCs were oxidized into urea derivatives and hydrolyzed into imidazoliums or benzimidazoliums. The decomposition of Ag-NHC with a saturated backbone led to ring-opening product, while the Ag-NHC with an unsaturated backbone led to imidazolium and Ag-bisNHC complex. The effects of steric property, hydrophilicity, and binding energy of NHC to O₂ and H₂O on the decomposition of Cu(I)-NHC were studied using theor. calculations Steric hindrance played an important role on the stability of Cu(I)-NHC. Pathways for the decomposition of Cu(I)-NHC and Ag-NHC were proposed.

Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem