Month: October 2022

Product Details of 7720-39-0In 2017 ,《Synthesis, dyeing performance on polyester fiber and antimicrobial studies of some novel pyrazolotriazine and pyrazolyl pyrazolone azo dyes》 appeared in Arabian Journal of Chemistry. The author of the article were Rizk, Hala F.; Ibrahim, Seham A.; El-Borai, Mohammed A.. The article conveys some information:

The 5-amino-4-heterylazo-3-phenyl-1H-pyrazoles (2a-d) were diazotized and coupled with malononitrile to give pyrazoloazo malononitrile which by heating in glacial acetic acid gave novel pyrazolo[5,1-c][1,2,4]triazine dyes (3a-d). Also, some diazopyrazolyl pyrazolone dyes (4a-h) were synthesized by diazotization of 2a-d and coupled with some pyrazolone derivatives The structure of the synthesized dyes was determined by elemental anal. and spectral data. All the synthesized compounds were applied as disperse dyes and their dyeing performance on polyester fabric was studied. The fastness and colorimetric properties were measured. The results revealed that the monoazo dyes have good fastness and good to moderate affinity to polyester fabric than diazo dyes. In addition, the synthesized dyes were screened for their antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa (Gram pos.), Bacillus subtitles, Escherichia coli (Gram neg.) and Candida albicans, Aspergillus niger (Fungi). The results revealed that most of the prepared dyes have high antibacterial activity. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7720-39-0In 2021 ,《A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors》 was published in RSC Medicinal Chemistry. The article was written by Weig, Alexander W.; Barlock, Samantha L.; O’Connor, Patrick M.; Marciano, Orry M.; Smith, Richard; Ernst, Robert K.; Melander, Roberta J.; Melander, Christian. The article contains the following contents:

Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to conventional antibiotics, necessitating the development of alternative approaches to treat biofilm-based infections. One such approach is the development of small mol. adjuvants that can inhibit/disrupt bacterial biofilms. When such mols. are paired with conventional antibiotics, these dual treatments present a combination approach to eradicate biofilm-based infections. Previously, we have demonstrated that small mols. containing either a 2-amino pyrimidine (2-AP) or a 2-aminoimidazole (2-AI) heterocycle are potent anti-biofilm agents. Herein, we now report a scaffold hopping strategy to generate new aryl 2-AP analogs that inhibit biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA). These mols. also suppress colistin resistance in colistin resistant Klebsiella pneumoniae, lowering the min. inhibitory concentration (MIC) by 32-fold. The results came from multiple reactions, including the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acidIn 2020 ,《Strong Adverse Contribution of Conformational Dynamics to Streptavidin-Biotin Binding》 was published in Journal of Physical Chemistry B. The article was written by Sarter, Mona; Niether, Doreen; Koenig, Bernd W.; Lohstroh, Wiebke; Zamponi, Michaela; Jalarvo, Niina H.; Wiegand, Simone; Fitter, Joerg; Stadler, Andreas M.. The article contains the following contents:

Mol. dynamics plays an important role for the biol. function of proteins. For protein ligand interactions, changes of conformational entropy of protein and hydration layer are relevant for the binding process. Quasielastic neutron scattering (QENS) was used to investigate differences in protein dynamics and conformational entropy of ligand-bound and ligand-free streptavidin. Protein dynamics were probed both on the fast picosecond time scale using neutron time-of-flight spectroscopy and on the slower nanosecond time scale using high-resolution neutron backscattering spectroscopy. We found the internal equilibrium motions of streptavidin and the corresponding mean square displacements (MSDs) to be greatly reduced upon biotin binding. On the basis of the observed MSDs, we calculated the difference of conformational entropy ΔSconf of the protein component between ligand-bound and ligand-free streptavidin. The rather large neg. ΔSconf value (-2 kJ mol-1 K-1 on the nanosecond time scale) obtained for the streptavidin tetramer seems to be counterintuitive, given the exceptionally high affinity of streptavidin-biotin binding. Literature data on the total entropy change ΔS observed upon biotin binding to streptavidin, which includes contributions from both the protein and the hydration water, suggest partial compensation of the unfavorable ΔSconf by a large pos. entropy gain of the surrounding hydration layer and water mols. that are displaced during ligand binding. The experimental process involved the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Application In Synthesis of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Application In Synthesis of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formula: C4H6N2In 2019 ,《Superhydrophilic, Underwater Directional Oil-Transport Fabrics with a Novel Oil Trapping Function》 was published in ACS Applied Materials & Interfaces. The article was written by Fu, Sida; Zhou, Hua; Wang, Hongxia; Niu, Haitao; Yang, Weidong; Shao, Hao; Wang, Jinnan; Lin, Tong. The article contains the following contents:

In this study, we have prepared a novel superhydrophilic fabric that has underwater directional oil-transport capability. The fabric was prepared using a two-step process consisting of dip-coating of a crosslinkable polymer, which comprises both oleophilic and hydrophilic groups, onto the fabric substrate and single-side UV irradiation of the coated fabric. The fabric had in-air superhydrophilicity on both sides, and it can be wetted easily once immersed in water. The treated fabric showed underwater oleophobicity on the UV-exposed surface, whereas the unexposed back side still maintained underwater oleophilicity. At the optimized condition, the fabric in water transports oil automatically from the UV-exposed to the unexposed back side but stops oil transport in the opposite direction. Such a directional oil transport takes place without the need for oil prewetting or formation of a plastron layer on fabric. The UV irradiation time showed an effect on oil-transport ability. We further showed that the underwater directional oil-transport fabric had a novel “”oil trapping”” ability. When used to seal a container, the fabric can trap oil into the container, and once trapped, the oil was kept without releasing. This underwater directional oil-transport fabric may be useful for the development of high-efficiency oil recovery systems.1-Methyl-1H-imidazole(cas: 616-47-7Formula: C4H6N2) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Formula: C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of 1H-Imidazol-2-amineIn 2017 ,《Synthesis and characterization of S(-)1-phenyl-1,2,3,4-tetrahydro isoquinoline acetamide analogues》 was published in Asian Journal of Chemistry. The article was written by Krishna Rao, N.; Surendra Babu, M.; Basaveswara Rao, M. V.; Keshavi, R.; Sundara Rao, N.; Eswara Prasad, N. H.; Murthy, Y. L. N.. The article contains the following contents:

S(-)1-Phenyl-1,2,3,4-tetrahydroisoquinoline acetamide analogs are prepared by sequence of reactions which involve a metal hydride reduction of 3,4-dihydroisoquinoline followed by separation of S-form with mandelic acid (chiral reagent) by resolution The product S(-)1-phenyl-1,2,3,4-tetrahydroisoquinoline is treated with chloroacetyl chloride to obtain tetrahydroisoquinoline acetyl chloride which is further employed to synthesize acetamide derivatives of tetrahydroisoquinoline I [R = Ph, 4-hydroxyphenyl, pyrimidin-2-yl, etc.] using various substituted aryl amines RNH2. The products were characterized by advanced spectroscopic techniques.1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Azolium Aurates as Pre-Catalysts for the Oxidative Coupling of Terminal Alkynes under Mild Conditions》 was written by Ma, Xinyuan; Tzouras, Nikolaos V.; Peng, Min; Van Hecke, Kristof; Nolan, Steven P.. SDS of cas: 258278-25-0 And the article was included in Journal of Organic Chemistry on April 1 ,2022. The article conveys some information:

A simple and efficient method for the oxidative coupling of terminal alkynes was reported for the first time, using imidazol(in)ium aurates as pre-catalysts. This approach displayed high functional group tolerance and led to a broad range of 1,3-diyne compounds in moderate to excellent yields using low catalyst loading and was performed in air under mild and sustainable conditions. In addition to this study using 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, there are many other studies that have used 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0SDS of cas: 258278-25-0) was used in this study.

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) may be used as a precursor to the free carbene 1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene, and also used as an in situ formed catalyst in a variety of reactions, e.g. amination, Heck coupling reaction, the ring-opening metathesis polymerization (ROMP), hydrogenation.SDS of cas: 258278-25-0In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis》 was written by Devine, William G.; Diaz-Gonzalez, Rosario; Ceballos-Perez, Gloria; Rojas, Domingo; Satoh, Takashi; Tear, Westley; Ranade, Ranae M.; Barros-Alvarez, Ximena; Hol, Wim G. J.; Buckner, Frederick S.; Navarro, Miguel; Pollastri, Michael P.. Recommanded Product: 2-Chloro-1H-benzo[d]imidazoleThis research focused ontrypanosomiasis trypanosomicide Trypanosoma; crystal structure; Trypanosoma brucei; medicinal chemistry; methionyl-tRNA synthetase. The article conveys some information:

Human African Trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. NEU-1053 I has recently been identified from a high throughput screen of >42,000 compounds as a highly potent and fast acting trypanocidal agent capable of curing a blood stream infection of T. brucei in mice. The authors have designed a library of analogs to probe the SAR and improve the predicted CNS exposure of NEU-1053. The authors report the activity of these inhibitors of Trypanosoma brucei, the efficacy of NEU-1053 in a murine CNS model of infection, and identification of the target of NEU-1053 via x-ray crystallog. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Rapid and mild synthesis of Au-NHC complexes in a simple two-phase flow reactor》 was published in Dalton Transactions in 2021. These research results belong to Jonsson, Helgi Freyr; Fiksdahl, Anne; Harvie, Andrew J.. Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride The article mentions the following:

We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)-NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)-NHC complexes, without isolation of the Au(I)-NHC intermediate, with a two-step isolated yield of 82%. After reading the article, we found that the author used 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) may be used as a precursor to the free carbene 1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene, and also used as an in situ formed catalyst in a variety of reactions, e.g. amination, Heck coupling reaction, the ring-opening metathesis polymerization (ROMP), hydrogenation.Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chlorideIn addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives》 was written by Malamiri, Fatemeh; Khaksar, Samad; Badri, Rashid; Tahanpesar, Elham. Safety of 1H-Benzo[d]imidazol-2-amineThis research focused ontriazoloquinazolinone preparation; aminotriazole dimedone benzaldehyde cyclocondensation trifluoroethanol mediated; benzimidazoloquinazolinone preparation; aminobenzimidazole dimedone benzaldehyde cyclocondensation trifluoroethanol mediated; Fluorinated alcohols; anticancer; green chemistry; heterocyclic; multicomponent; triazole. The article conveys some information:

An efficient and catalyst-free procedure for the synthesis of triazoloquinazolinones I [Ar = Ph, 4-MeC6H4, 2,4-di-ClC6H3, etc.] and benzimidazoloquinazolinones II [R = Ph, 4-ClC6H4, 4-O2NC6H4, etc.] was developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean and reusable media. Various products were obtained in good to excellent yields under reaction conditions. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 2403-66-9On September 12, 2005 ,《Selective nitrogen protection of hydroxyalkylbenzimidazoles using 2,2,2-trichloroethylchloroformate》 was published in Tetrahedron Letters. The article was written by Woudenberg, Richard C.; Coughlin, E. Bryan. The article contains the following contents:

A method for selective N-protection of hydroxyalkylbenzimidazoles using 2,2,2-trichloroethylchloroformate (Troc-Cl) applicable to various alkyl chain lengths was developed. In the specific case of 5-(1-[2,2,2-trichloroethyl formyl]-benzimidazol-2-yl)-propan-1-ol, migration of Troc from the benzimidazole to the primary alc. occurs in the presence of triethylamine, allowing the choice of selective N-Troc or O-Troc protection. After reading the article, we found that the author used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Product Details of 2403-66-9)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Product Details of 2403-66-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem