Month: October 2022

Hermanns, Volker; Scheurer, Maximilian; Kersten, Nils Frederik; Abdellaoui, Chahinez; Wachtveitl, Josef; Dreuw, Andreas; Heckel, Alexander published their research in Chemistry – A European Journal in 2021. The article was titled 《Rethinking Uncaging: A New Antiaromatic Photocage Driven by a Gain of Resonance Energy》.Recommanded Product: 530-62-1 The article contains the following contents:

Photoactivatable compounds for example photoswitches or photolabile protecting groups (PPGs, photocages) for spatiotemporal light control, play a crucial role in different areas of research. For each application, parameters such as the absorption spectrum, solubility in the resp. media and/or photochem. quantum yields for several competing processes need to be optimized. The design of new photochem. tools therefore remains an important task. In this study, we exploited the concept of excited-state-aromaticity, first described by N. Colin Baird in 1971, to investigate a new class of photocages, based on cyclic, ground-state-antiarom. systems. Several thio- and nitrogen-functionalized compounds were synthesized, photochem. characterized and further optimized, supported by quantum chem. calculations After choosing the optimal scaffold, which shows an excellent uncaging quantum yield of 28 %, we achieved a bathochromic shift of over 100 nm, resulting in a robust, well accessible, visible light absorbing, compact new photocage with a clean photoreaction and a high quantum product (ε·Φ) of 893 M-1 cm-1 at 405 nm. The results came from multiple reactions, including the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sirithanakorn, Chaiyos; Cronan, John E. published their research in FEMS Microbiology Reviews in 2021. The article was titled 《Biotin, a universal and essential cofactor: synthesis, ligation and regulation》.Application of 58-85-5 The article contains the following contents:

Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all three domains of life. Several important human pathogens (e.g. Mycobacterium tuberculosis) require biotin synthesis for pathogenesis. Humans lack a biotin synthetic pathway hence bacterial biotin synthesis is a prime target for new therapeutic agents. The biotin synthetic pathway is readily divided into early and late segments. Although pimelate, a 7-carbon α,ω-dicarboxylic acid that contributes 7 of the 10 biotin carbons atoms, was long known to be a biotin precursor, its biosynthetic pathway was a mystery until the Escherichia coli pathway was discovered in 2010. Since then, diverse bacteria encode evolutionarily distinct enzymes that replace enzymes in the E. coli pathway. Two new bacterial pimelate synthesis pathways have been elucidated. In contrast to the early pathway, the late pathway, assembly of the fused rings of the cofactor, was long thought settled. However, a new enzyme that bypasses a canonical enzyme was recently discovered as well as homologs of another canonical enzyme that functions in synthesis of another protein-bound coenzyme, lipoic acid. Most bacteria tightly regulate transcription of the biotin synthetic genes in a biotin-responsive manner. The bifunctional biotin ligases which catalyze attachment of biotin to its cognate enzymes and repress biotin gene transcription are best understood regulatory system. The results came from multiple reactions, including the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Application of 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Application of 58-85-5 The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Beibei; Guo, Ruixue; Tian, Jie; Wang, Zunyao; Qu, Ruijuan published an article in 2021. The article was titled 《New Findings of Ferrate(VI) Oxidation Mechanism from Its Degradation of Alkene Imidazole Ionic Liquids》, and you may find the article in Environmental Science & Technology.HPLC of Formula: 16681-56-4 The information in the text is summarized as follows:

Chem. reactivity, kinetics, degradation pathways and mechanisms, and ecotoxicity of the oxidation of 1-vinyl-3-ethylimidazolium bromide ([VEIm]Br), the most common alternative to organic solvents, by Fe(VI) (HFeO4-) were studied by lab experiments and theor. calculations Results show that Fe(VI) can efficiently remove VEIm through the dioxygen transfer-hydrolysis mechanism, which has not been reported yet. The reactivity of VEIm toward Fe(VI) mainly depends on the double bonds in the side chain of VEIm. The second-order rate constant for VEIm was 629.45 M-1 s-1 at pH 7.0 and 25°C. Typical water constituents, except for SO32-, Cl-, and Cu2+, had no obvious effects on the oxidation The oxidation products were determined by high-performance liquid chromatog. hybrid quadrupole time-of-flight mass spectrometry, which proves that there were interactions between the oxidation intermediates of the anion and cation parts of [VEIm]Br during the degradation process. The structures of related products and oxidation mechanisms were further rationalized by theor. calculations The ecotoxicity of products from the three oxidation pathways all showed a trend of increase after the initial decrease. We hope that the findings of this work can give researchers some new inspirations on Fe(VI) degradation of other alkene-containing contaminants. After reading the article, we found that the author used 2-Bromo-1H-imidazole(cas: 16681-56-4HPLC of Formula: 16681-56-4)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. HPLC of Formula: 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborateIn 2019 ,《Using an ionic liquid to reduce the electrical percolation threshold in biobased thermoplastic polyurethane/graphene nanocomposites》 appeared in Polymers (Basel, Switzerland). The author of the article were Aranburu, Nora; Otaegi, Itziar; Guerrica-Echevarria, Gonzalo. The article conveys some information:

Biobased thermoplastic polyurethane (bTPU)/unmodified graphene (GR) nanocomposites (NCs) were obtained by melt-mixing in a lab-scaled conventional twin-screw extruder. Alternatively, GR was also modified with an ionic liquid (GR-IL) using a simple preparation method with the aim of improving the dispersion level. XRD diffractograms indicated a minor presence of well-ordered structures in both bTPU/GR and bTPU/GR-IL NCs, which also showed, as observed by TEM, nonuniform dispersion. Elec. conductivity measurements pointed to an improved dispersion level when GR was modified with the IL, because the bTPU/GR-IL NCs showed a significantly lower elec. percolation threshold (1.99 wt%) than the bTPU/GR NCs (3.21 wt%), as well as higher conductivity values. Young’s modulus increased upon the addition of the GR (by 65% with 4 wt%), as did the yield strength, while the ductile nature of the bTPU matrix maintained in all the compositions, with elongation at break values above 200%. This pos. effect on the mech. properties caused by the addition of GR maintained or slightly increased when GR-IL was used, pointing to the success of this method of modifying the nanofiller to obtain bTPU/GR NCs. In addition to this study using 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate, there are many other studies that have used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate) was used in this study.

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2020 ,《pH-sensitive, dynamic graft polymer micelles via simple synthesis for enhanced chemotherapeutic efficacy》 appeared in Journal of Biomaterials Applications. The author of the article were Li, Dapeng; Qin, Jiejie; Sun, Min; Yan, Guoqing; Tang, Rupei. The article conveys some information:

To promote chemotherapeutic efficacy and easier clin. transformation, a series of pH-sensitive and dynamic drug delivery systems with facile two-step synthesis and simple structure have been successfully constructed by the tunable grafting reaction between pH-sensitive ortho ester and poly(vinyl alc.). The amphipathic graft macromols. (PVA-g-OEx, x represents the percentage of feed between ortho esters and hydroxyl groups of polyvinyl alc.) could self-assemble into micelles and doxorubicin was embedded. These micelles exhibited pH-sensitivity to both extracellular and intracellular pH and demonstrated the following characteristics: (i) maintaining long-term storage and blood circulation stability at pH 7.4; (ii) responding to tumoral extracellular pH value following gradually larger nanoparticles for improved drug accumulation and retention; (iii) being sensitive to tumoral intracellular pH value following disintegration for rapid drug release to improve toxicity to tumor cells. Moreover, the doxorubicin-loaded micelle (PVA-g-OE30-DOX) showed similar cytotoxicity to free doxorubicin in vitro, but stronger tumor penetration and inhibition ability in vitro human liver carcinoma cell line multicellular tumor spheroids. In vivo biodistribution and tumor inhibition examinations demonstrated that PVA-g-OE30-DOX had more superior efficacy in significantly enhancing drug accumulation in tumor, restraining tumor growth while decreasing drug concentration in normal tissues. The pH-sensitive, dynamic graft polymer micelles via simple synthesis could be considered as a promising and effective drug carrier in tumor therapy. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Category: imidazoles-derivatives)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: Di(1H-imidazol-1-yl)methanoneIn 2021 ,《Rhenium Nanostructures Loaded into Amino-Functionalized Resin as a Nanocomposite Catalyst for Hydrogenation of 4-Nitrophenol and 4-Nitroaniline》 appeared in Polymers (Basel, Switzerland). The author of the article were Cyganowski, Piotr; Dzimitrowicz, Anna; Jamroz, Piotr; Jermakowicz-Bartkowiak, Dorota; Pohl, Pawel. The article conveys some information:

The present work presents a new nanocomposite catalyst with rhenium nanostructures (ReNSs) for the catalytic hydrogenation of 4-nitrophenol and 4-nitroaniline. The catalyst, based on an anion exchange resin with functionality derived from 1,1′-carboimidazole, was obtained in the process involving anion exchange of ReO4- ions followed by their reduction with NaBH4. The amino functionality present in the resin played a primary role in the stabilization of the resultant ReNSs, consisting of ≈1% (weight/weight) Re in the polymer mass. The synthesized and capped ReNSs were amorphous and had the average size of 3.45 ± 1.85 nm. Then, the obtained catalyst was used in a catalytic reduction of 4-nitrophenol (4-NP) and 4-nitroaniline (4-NA). Following the pseudo-first-order kinetics, 5 mg of the catalyst led to a 90% conversion of 4-NP with the mass-normalized rate constant (km1) of 6.94 x 10-3 min-1 mg-1, while the corresponding value acquired for 4-NA was 7.2 x 10-3 min-1 mg-1, despite the trace amount of Re in the heterogenous catalyst. The obtained material was also conveniently reused. In the experiment, the researchers used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Name: Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Name: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 1H-Benzo[d]imidazol-2-amineIn 2021 ,《Characterization of a novel carbendazim-degrading strain Rhodococcus sp. CX-1 revealed by genome and transcriptome analyses》 was published in Science of the Total Environment. The article was written by Long, Zhengnan; Wang, Xiuguo; Wang, Yingjun; Dai, Huawei; Li, Changhao; Xue, Yongfei; Deng, Yanfei; Zhang, Houpu; Yu, Yunlong; Fang, Hua. The article contains the following contents:

The persistence and ecotoxicity of carbendazim residues pose a potential risk to environmental ecol. and human health. Here, a novel and highly efficient carbendazim-degrading bacterium Rhodococcus sp. CX-1, capable of utilizing carbendazim as its sole source of carbon and energy, was isolated from contaminated soil. The biodegradation characteristics and metabolic pathways were studied by mass spectrometry, genomic annotation, and transcriptome anal. The degradation rate of carbendazim by strain CX-1 was 3.98-9.90 mg/L/h under different conditions, and the optimum degradation conditions were 40°C and pH 7.0. The addition of carbon sources (glucose, fructose, and sucrose, 100 mg/L) could accelerate carbendazim degradation HPLC-MS/MS identification suggested that carbendazim is first hydrolyzed into 2-aminobenzimidazole and then to 2-hydroxybenzimidazole, and is ultimately mineralized to carbon dioxide. The genome of strain CX-1 contained 6,511,628 bp nucleotides, 2 linear plasmids, 2 circular plasmids, and 6437 protein coding genes. Genome annotation and transcriptome anal. indicated that carbendazim degradation may be regulated by the degradation genes harbored in the chromosome and in plasmid 2, and two different degradation pathways of carbendazim by imidazole ring cleavage or benzene ring cleavage were predicted. This study provided new insight to reveal the biodegradation mechanism of carbendazim; furthermore, strain CX-1 is a promising bioresource for carbendazim bioremediation. In the experimental materials used by the author, we found 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: Di(1H-imidazol-1-yl)methanoneIn 2019 ,《Gold nano-urchin integrated label-free amperometric aptasensing human blood clotting factor IX: A prognosticative approach for “”Royal disease””》 was published in Biosensors & Bioelectronics. The article was written by Letchumanan, Iswary; Gopinath, Subash C. B.; Arshad, M. K. Md; Anbu, Periasamy; Lakshmipriya, Thangavel. The article contains the following contents:

This article is clearly presenting the development of a biosensor for human factor IX (FIX) to diagnose the blood clotting deficiency, a so-called ‘Royal disease’ using an interdigitated electrode (IDE) with the zinc oxide surface modification. Gold nano-urchins (GNUs) with 60 nm in diameter was integrated into a streptavidin-biotinylated aptamer strategy to enhance the active surface area. Two different comparative studies have been done to validate the system to be practiced in the current work holds with a higher capability for the high-performance sense. Whereby, the presence and absence of GNUs in the aptasensing system for FIX interaction were investigated using the amperometric measurement, using a linear sweep voltage of 0-2 V at 0.01 V step voltage. The detection limit was 6 pM based on 3s calculation when GNUs integrated aptamer assay was utilized for FIX detection, which shows 8 folds sensitivity enhancement comparing the condition in the absence of GNU and 50 folds higher than sensitive radio-isotope and surface plasmon resonance assays. Albeit, the surface and mol. characterizations were well demonstrated by SEM, at. force microscopy, 3D nano-profilometry and further supports were rendered by UV-Vis spectroscopy and Enzyme-linked apta-sorbent assay (ELASA). Furthermore, the spiking experiment was done by FIX-spikes in human blood serum in order to demonstrate the stability with a higher non-fouling.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Name: Di(1H-imidazol-1-yl)methanone) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Name: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 616-47-7In 2019 ,《Self-assembled structure and dynamics of imidazolium-based protic salts in water solution》 was published in Physical Chemistry Chemical Physics. The article was written by Zhu, Haijin; Vijayaraghavan, R.; MacFarlane, Douglas R.; Forsyth, Maria. The article contains the following contents:

Protic ionic liquids containing cations with long alkyl chains can form self-assembled micelles, vesicles, microemulsions, and lyotropic liquid crystal structures in water, acid water or THF, etc. As a result of this unique property, they are regarded as a novel category of amphiphiles, and are gaining importance in the field of colloid and interface chem. The critical micelle concentration (CMC) of protic salts, e.g., alkyl-ammonium nitrates in water, was found to increase with decreasing chain length. It is generally believed that a long alkyl chain length is essential for the formation of self-assembled structures. So far, no self-assembled structure has been reported for protic ionic liquids with an alkyl chain length of n < 4. This paper reports on the structure and dynamics of two imidazolium based protic organic salts with no alkyl chain or a Me group (n = 1) attached to the cation in water solution, determined through a detailed anal. of NMR spectra and pulsed-field gradient NMR data. We demonstrate that these imidazolium cations with no or a short alkyl chain (n = 1) can form a self-assembled clustering structure in water solution, which has a strong influence on the diffusion behavior of imidazolium mol. ions. It is speculated that this self-assembled structure is likely to be present in other similar solutions of ionic liquids with short alkyl chains.1-Methyl-1H-imidazole(cas: 616-47-7Product Details of 616-47-7) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Product Details of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 1H-Benzo[d]imidazol-2-amineIn 2021 ,《Augmentation of steroidal β-formylenamide with pyrazolo and benzimidazo moieties: A tandem approach to highly fluorescent steroidal heterocycles》 was published in Tetrahedron Letters. The article was written by Nongthombam, Geetmani Singh; Boruah, Romesh Chandra. The article contains the following contents:

A facile synthesis of pyrazolo[1,5-a]pyrimidine and benzimidazo[1,2-a]pyrimidine-annulated steroids is described from the novel reaction of β-formyl enamides with amino pyrazoles, indazoles and benzimidazoles. Several of the products exhibited fluorescence properties with high quantum yields. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem