Month: October 2022

In 2018,Journal of Medicinal Chemistry included an article by Norman, Bryan H.; Fisher, Matthew J.; Schiffler, Matthew A.; Kuklish, Steven L.; Hughes, Norman E.; Czeskis, Boris A.; Cassidy, Kenneth C.; Abraham, Trent L.; Alberts, Jeffrey J.; Luffer-Atlas, Debra. Name: 1H-Imidazol-2-amine. The article was titled 《Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury》. The information in the text is summarized as follows:

Two 2-aminoimidazole-based inhibitors, LY3031207 (1) and LY3023703 (2), of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver injury (DILI) in humans. We studied imidazole ring substitutions to successfully mitigate reactive metabolite (RM) formation. These studies support the conclusion that RM formation may play a role in the observations of DILI and the consideration of 2-aminoimidazoles as structure alerts, due to the high likelihood of bioactivation to generate RMs. The results came from multiple reactions, including the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Name: 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Saha, Abhishek; Akhtar, Nasim; Kumar, Vishnu; Kumar, Suresh; Srivastava, Hemant Kumar; Kumar, Sachin; Manna, Debasis. COA of Formula: C7H5ClN2. The article was titled 《pH-regulated anion transport activities of bis(iminourea) derivatives across the cell and vesicle membrane》. The information in the text is summarized as follows:

Recently, synthetic anion transporters have gained considerable attention because of their ability to disrupt cellular anion homeostasis and promote cell death. Herein, we report the development of bis(iminourea) derivatives as a new class of selective Cl- ion carrier. The bis(iminourea) derivatives were synthesized via a one-pot approach under mild reaction conditions. The presence of iminourea moieties suggests that the bis(iminourea) derivatives can be considered as unique guanidine mimics, indicating that the protonated framework could have much stronger anion recognition properties. The cooperative interactions of H+ and Cl- ions with these iminourea moieties results in the efficient transport of HCl across the lipid bilayer in an acidic environment. Under physiol. conditions these compounds weakly transport Cl- ions via an antiport exchange mechanism. This pH-dependent gating/switching behavior (9-fold) within a narrow window could be due to the apparent pKa values (6.2-6.7) of the compounds within the lipid bilayer. The disruption of ionic homeostasis by the potent compounds was found to induce cell death. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1COA of Formula: C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.COA of Formula: C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Saudi Chemical Society included an article by Karimi, Maryam; Naimi-Jamal, M. R.. Application In Synthesis of 1H-Benzo[d]imidazol-2-amine. The article was titled 《Carboxymethyl cellulose as a green and biodegradable catalyst for the solvent-free synthesis of benzimidazoloquinazolinone derivatives》. The information in the text is summarized as follows:

CM-cellulose (CMC) was used as an efficient, and environmentally friendly catalyst for the solvent-free three-component synthesis of quinazolinone derivatives by condensation of 2-aminobenzimidazole, dimedone or 1,3-cyclohexanedione, and different aldehydes. The catalyst was recovered easily, and reused without significant loss of its activity. Solvent-free and mild reaction conditions, nontoxic-, biodegradable-, and inexpensive catalyst, environmentally benign method, and high to excellent yields are some important features of this protocol. In addition to this study using 1H-Benzo[d]imidazol-2-amine, there are many other studies that have used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application In Synthesis of 1H-Benzo[d]imidazol-2-amine) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application In Synthesis of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Water molecular state in 1-hexylpyridinium hexafluorophosphate: Water mean cluster size as a function of water concentration》 were Dahi, Abdellatif; Fatyeyeva, Kateryna; Chappey, Corinne; Langevin, Dominique; Marais, Stephane. And the article was published in Journal of Molecular Liquids in 2019. COA of Formula: C8H15BF4N2 The author mentioned the following in the article:

The water sorption behavior of representative pyridinium-based ionic liquid (IL), 1-hexylpyridinium hexafluorophosphate ([C6Py][PF6]), was studied over the whole range of the water activity a using a continuous gravimetric method. The anal. of the water sorption isotherm using the combination of a two-mode sorption (i.e. Henry-clustering) allowed to better understand [C6Py][PF6]-water interactions. At low and intermediate activity (a ≤ 0.8), the water mols. revealed a very low affinity to [C6Py][PF6] and, consequently, the water uptake was rather low. On the contrary, at high water activity (a > 0.8), the water uptake increased exponentially and the water clustering easily occurred. The constant of the Henry-clustering equation as well as the water clustering mechanism in [C6Py][PF6] were discussed and compared to those of imidazolium-based ILs: 1-hexyl-3-methylimidazolium hexafluorophosphate [C6C1i.m.][PF6] (water-immiscible IL) and 1-butyl-3-methylimidazolium tetrafluoroborate [C4C1i.m.][BF4] (water-miscible IL). It is shown that the sorption of water mols. by pyridinium-based ILs is controlled not only by the anion’s nature, but also by the cation’s nature. Moreover, the Zimm-Lundberg theory was used to determine the water mean cluster size (MCS) in [C6Py][PF6], [C6C1i.m.][PF6] and [C4C1i.m.][BF4]. The MCS results confirmed the strong capacity of water mols. to be aggregated in [C6Py][PF6]. In order to have a deeper insight into the water mol. state, IR spectroscopy measurements were carried out as a function of the relative humidity value and the obtained results were correlated with the results of water sorption isotherms. It is found that at high water activity (a > 0.8), sorbed water mols. are strongly linked with ILs by hydrogen bonds and, therefore, are easily aggregated. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Amino-functional ZIF-8 nanocrystals by microemulsion based mixed linker strategy and the enhanced CO2/N2 separation》 was published in Separation and Purification Technology in 2020. These research results belong to Ding, Rui; Zheng, Wenji; Yang, Kai; Dai, Yan; Ruan, Xuehua; Yan, Xiaoming; He, Gaohong. Electric Literature of C7H7N3 The article mentions the following:

High permeability and selectivity are desirable for mixed matrix membranes (MMMs) based CO2 separation Herein, a microemulsion based mixed linker strategy is proposed to introduce amino groups during the growth of ZIF-8. Compared to post-synthetic modification, this method presents a less reduction in SBET of ZIF-8, which is beneficial for CO2 adsorption. By controlling the ratio of 2-methylimidazole to 2-aminobenzimidazole, NH2-ZIF-8 with various morphologies and sizes were synthesized and serve as the filler to fabricate the MMMs for CO2 capture. From the SEM, no obvious agglomerations or defects are observed in ZIF-8/Pebax MMMs, due to the amino groups in ZIF-8 can interact with the amide in Pebax chain, which can improve compatibility between ZIF-8 and Pebax. With the amino groups, NH2-ZIF-8 shows higher affinity with CO2 than that of non-amine-functionalized ZIF-8, leading to an enhancement in the separation performances. When the MMM doped with 6 weight% of NH2-ZIF-8(10), the CO2 permeability reaches up to 163.8 Barrer, which increases by around 53% and 107.6% in contrast with the ZIF-8/Pebax MMM and pure Pebax membrane. Besides, the CO2/N2 selectivity is enhanced by around 10% and 27%, resp. These results indicate that amine-functional modification by mixed ligands is a useful way to construct MOFs-based MMMs with high performance for CO2/N2 separation The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Spicing Up an Interdisciplinary Chemical Biology Course with the Authentic Big Picture of Epigenetic Research》 was written by Heinrich, Benedikt; Graulich, Nicole; Vazquez, Olalla. Quality Control of 1-Methyl-1H-imidazole And the article was included in Journal of Chemical Education in 2020. The article conveys some information:

A review. The complexity of the world’s current grand challenges demands interdisciplinary approaches. The education of future scientists must cross the silos of the traditional disciplines; however, there is still a strong reluctance to tear such walls down. Here, we describe an integrative chem. biol. course focused on epigenetics that strives to bring research culture to chem. and biol. Master’s students. The course, which has been successfully implemented for the past two years, combines three modules: lectures, discovery-based research lab, and science communication. Importantly, the outline of our course design could be easily adapted to different fields, improving the synergy between research and teaching in our universities. The experimental process involved the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Quality Control of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Quality Control of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis, spectroscopic characterizations, DFT, molecular docking and molecular dynamics simulations of a novel 2-methyl-3H-benzimidazolo[1,2-b][1,2,4]triazepin-4(5H)-one》 was written by El Bakri, Youness; Anouar, El Hassane; Subramani, Karthikeyan; Ben-Yahya, Ali; Essassi, El Mokhtar. COA of Formula: C7H7N3 And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

A novel compound named 2-methyl-3H-benzimidazolo[1,2-b][1,2,4]triazepin-4(5H)-one I was synthesized and characterized by spectroscopic techniques (FT-IR), UV-Vis, 1H NMR, 13C NMR and mass spectra. The optimized mol. structure anal., vibrational wave numbers, 13C and 1H NMR chem. shifts of the title mol. had been performed at DFT/B3LYP method with 6-31 + G(d,p) basis set. The electronic absorption wavelengths computed using B3LYP, B3P86 and PBE0 hybrid functional. The scaled vibrational modes and the predicted 13C NMR and 1H NMR chem. shifts were relatively in good agreement with the corresponding exptl. ones. However, B3LYP, B3P86 and PBE0 hybrid functional failed in reproduction of exptl. λMAX of the tilted compound and it was underestimated by the tested hybrid functionals with deviations to the exptl. values of 30, 34 and 40 nm for B3LYP, B3P86 and PBE0, resp. In addition, mol. docking and mol. dynamics simulations of titled compound were carried out to determine its binding modes and stability within the leucine-rich repeat kinase 2 active site. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties》 was written by Concellon, Alberto; Anselmo, Maria San; Hernandez-Ainsa, Silvia; Romero, Pilar; Marcos, Mercedes; Serrano, Jose Luis. HPLC of Formula: 530-62-1 And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:

The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic mols., and at the same time provided fluorescent traceability due to the presence of coumarin units in their chem. structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis, catalytic activity and medium fluorous recycle of fluorous analogues of PEPPSI catalysts》 was written by Simunek, Ondrej; Rybackova, Marketa; Svoboda, Martin; Kvicala, Jaroslav. Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride And the article was included in Journal of Fluorine Chemistry in 2020. The article conveys some information:

PEPPSI complexes are air and moisture stable Pd catalysts, which can be used conveniently in many coupling reactions. With the aim to obtain Pd catalysts recyclable by fluorous separation methods, we modified the structure of com. PEPPSI complexes by per- or polyfluoroalkylation in various positions. The modifications included the use of a linear polyfluoroalkyl group instead of one aryl group on the NHC ligand, perfluoroalkylation of pyridine ligand, and substitution of chloride ligands on Pd for perfluoroalkanoates or perfluoropolyoxaalkanoates. Comparison of catalytic activity of com. catalysts with the modified ones in Suzuki-Miyaura cross-coupling reactions showed that the fluorous modifications mostly resulted in the increase of catalytic activity. Moreover, polyfluoroalkylation enabled efficient medium fluorous recycle of the modified catalysts using a two phase aqueous DMF/HFE 7500 ether system. In the part of experimental materials, we found many familiar compounds, such as 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Reference of 1,3-Dimesityl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aliabadi, Alireza; Hakimi, Mohammad; Hosseinabadi, Fatemeh; Motieiyan, Elham; Rodrigues, Vitor Hugo Nunes; Ghadermazi, Mohammad; Marabello, Domenica; Abdolmaleki, Sara published an article in 2021. The article was titled 《Investigation of X-ray crystal structure and in vitro cytotoxicity of two Ga(III) complexes containing pyridine dicarboxylic acid derivatives and 2-aminobenzimidazole》, and you may find the article in Journal of Molecular Structure.SDS of cas: 934-32-7 The information in the text is summarized as follows:

Two new coordination complexes were synthesized using the reaction of two organic salts with gallium(III) nitrate octahydrate. The salts were prepared and used as ligand from the reaction of 2-aminobenzimidazole with pyridine-2,6-dicarboxylic acid and 4-hydroxypyridine-2,6-dicarboxylic acid, resp. All compounds were identified by spectroscopic methods and their crystal structures determined by single crystal x-ray diffraction. The investigations showed that the two complexes were isostructural. Moreover, thermal anal. was carried out to study the decomposition steps of the complexes. The inhibition properties of the compounds were studied in vitro using oxaliplatin as a standard against five cell lines including a human breast cancer, a prostate cancer, a human liver hepatocellular carcinoma, a colorectal carcinoma and a human foreskin fibroblast. The anti-proliferative activity of the complexes is similar in the majority of cell lines except for the prostate cancer cells. The most remarkable cytotoxicity effect of both complexes appeared on the human breast cancer cells. Determination of mitochondrial membrane potential and reactive oxygen species in this cell line suggested that apoptosis may be the main pathway for the death of the cells. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7SDS of cas: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.SDS of cas: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem