Month: October 2022

Qian, Junfeng; Wu, Tingting; Shi, Jianqun; Chang, Hao; Liu, Donghui; Pan, Yichang published an article in 2021. The article was titled 《Improved CO2/CH4 separation performance of mixed-matrix membrane by adding ZIF-7-NH2 nanocrystals》, and you may find the article in Journal of Applied Polymer Science.Electric Literature of C7H7N3 The information in the text is summarized as follows:

Membrane-based technol. is an attractive alternative in terms of CO2 separation Pebax-based membranes are regarded as potential candidates for CO2 separation due to the favorable interaction between its poly(ethylene oxide) chains with CO2 mols. and inorganic fillers. However, the separation performance for CO2/CH4 mixture is still suffered from the moderate gas permeability and selectivity. To overcome this problem, in this work, amino-functionalized zeolite imidazolate framework (ZIF-7-NH2) nanocrystals were used as fillers to blend with Pebax 1657 for fabricating mixed-matrix membranes (MMMs). XRD, Brunauer-Emmett-Teller (BET), scanning electron microscope, and 1H NMR characterization indicated that ZIF-7-NH2 with the highest crystallinity was synthesized. Fourier transform IR spectroscopy, thermogravimetric anal., differential scanning calorimetry (DSC), and Young’s modulus showed that it has good interfacial interaction. Gas separation test results showed that both the CO2 permeability and CO2/CH4 selectivity of the 31 wt% ZIF-7-NH2/Pebax MMMs increased by 80 and 170%, resp. The improved performance is attributed to the addition of ZIF-7-NH2 nanocrystals and the favorable interfacial interactions between the polymer and ZIF-7-NH2 nanocrystals. Furthermore, the polyvinylidene fluoride supported hollow fiber composite membranes also exhibit the long-term stability for CO2/CH4 separation In addition to this study using 1H-Benzo[d]imidazol-2-amine, there are many other studies that have used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Nan; Yang, Hao; Li, Qing; Song, Lijun; Gopinath, Subash C. B.; Wu, Di published an article in 2021. The article was titled 《An interdigitated aptasensor to detect interleukin-6 for diagnosing rheumatoid arthritis in serum》, and you may find the article in Biotechnology and Applied Biochemistry.HPLC of Formula: 530-62-1 The information in the text is summarized as follows:

Rheumatoid arthritis (RA) is an autoimmune disorder causing chronic inflammation in the small joints of the articular bone and destruction of articular cartilage. RA causes stiffness, pain, joint destruction, substantial comorbidity, and functional disability. Early-stage diagnosis of RA can help in the treatment of the disease and expand the patient life span. Interleukins are a group of inflammatory cytokines; in particular, an abundance of interleukin-6 (IL-6) was found in the synovial fluid and serum. In RA patients, the levels of IL-6 have been found to be correlated with the disease, and this work focused on detecting IL-6 by its aptamer with the help of a biotin-streptavidin strategy on an interdigitated electrode. A sensitivity of 1 fM (0.021 pg/mL) and a limit of detection of 10 fM (0.21 pg/mL) were found by a linear regression [y = 0.6413x – 0.6249; R2 = 0.952] of the linear range from 1 fM to 100 pM. This method enhanced the immobilization of higher aptamer mols. for recognizing RA in serum-containing samples and is applicable to other diseases. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,St-Jean, Frederic; Angelaud, Remy; Bachmann, Stephan; Carrera, Diane E.; Remarchuk, Travis; Piechowicz, Katarzyna A.; Niedermann, Katrin; Iding, Hans; Meier, Roland; Hou, Haiyun; Sirois, Lauren E.; Xu, Jie; Olbrich, Martin; Rege, Pankaj; Guillemot-Plass, Maud; Gosselin, Francis published an article in Journal of Organic Chemistry. The title of the article was 《Stereoselective Synthesis of the IDO Inhibitor Navoximod》.COA of Formula: C3H3BrN2 The author mentioned the following in the article:

A highly efficient asym. synthesis of the IDO inhibitor navoximod, featuring the stereoselective installation of two relative and two absolute stereocenters from an advanced racemic intermediate, was described. The stereocenters were set via a crystallization-induced dynamic resolution along with two selective ketone reductions: one via a biocatalytic ketoreductase transformation and one via substrate-controlled hydride delivery from LiAlH(Ot-Bu)3. Following this strategy, navoximod were synthesized in 10 steps from 2-fluorobenzaldehyde and isolated in 23% overall yield with 99.8% ee and high purity. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4COA of Formula: C3H3BrN2)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. COA of Formula: C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Ghanbari, Hamed; Robertson, Katherine N.; Clyburne, Jason A. C.; Soleimani, Ebrahim published an article in Canadian Journal of Chemistry. The title of the article was 《Betaine formation from the reactions of N-heterocyclic carbenes with polarized alkenes》.SDS of cas: 141556-45-8 The author mentioned the following in the article:

N-Heterocyclic carbenes, 1,3-dimesityl-2-imidazolylidene (1a, IMes) or 1,3-bis(2,6-di-isopropylphenyl)imidazolidinylidene (1b, SIPr) react with the polarized alkenes ArCH:CX2 to form the crystalline betaines NHC-CHArCX2 (3a, 3b; Ar = 4-MeOC6H4, X2 = CONMeCSNMeCO; NHC = IMes, SIPr) and IMes-CHAr1C(CN)2 (5a; Ar1 = 2-MeOC6H4). Furthermore, a one-pot reaction between an aldehyde, malononitrile, and an imidazolium salt of an N-heterocyclic carbene has been developed for the efficient preparation of betaine 5a without isolation of the free carbene. Full characterization data, including X-ray crystal structures, is reported for the three synthesized betaines. The structures of the betaines 3a, 3b, and 5a shed new light on the initial products formed in the reactions between N-heterocyclic carbenes and compounds containing polarized double bonds. In addition to this study using 1,3-Dimesityl-1H-imidazol-3-ium chloride, there are many other studies that have used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8SDS of cas: 141556-45-8) was used in this study.

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.SDS of cas: 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

SDS of cas: 174501-65-6In 2019 ,《Nonbonding interaction analyses on PVDF/[BMIM][BF4] complex system in gas and solution phase》 appeared in Journal of Molecular Modeling. The author of the article were Sarkar, Ranjini; Kundu, T. K.. The article conveys some information:

The present study provides a detailed quantum chem. description of the physicochem. interactions between poly-vinylidene fluoride (PVDF) and 1-butyl-3-methyl-imidazolium tetrafluoro borate ([BMIM][BF4]) ionic liquid (IL). Geometry optimization and frequency calculations are carried out for four monomer units of α- and β-PVDF, [BMIM][BF4], and PVDF/[BMIM][BF4] using dispersion corrected d. functional theory. The effects of solvation on the systems under study are demonstrated for three polar aprotic solvents, namely tetra-hydrofuran (THF), acetone, and n,n-DMF (DMF) using the integral equation formalism polarizable continuum model (IEFPCM). Calculated neg. solvation free energy values suggest solution phase stability of the systems under study. Binding and interaction energies for β-PVDF/IL are found higher in magnitude than those for α-PVDF/IL. The nonbonding interaction phenomenon of β-PVDF/[BMIM][BF4] is elucidated on the basis of natural bond orbital (NBO), Bader’s quantum theory of atoms in mols. (QTAIM), delocalization indexes, Hirshfeld surface, and reduced d. gradient (RDG) analyses. Both anions and cations of ionic liquids are found to show weak van der Waals interaction with PVDF mol. but the anion ([BF4]-)/PVDF interaction is found to be stronger than cation ([BMIM]+)/PVDF interaction. Inter-unit C-H···F type hydrogen bonds are found to show improper (causing blue shifts in vibrational frequencies) nature. Frontier MO anal. is carried out, and different chem. parameters like electronegativity, chem. potential, chem. hardness and softness, and electrophilicity index are calculated using Koopmans’ theorem. Thermochem. calculations are also performed, and the variation in different standard thermodn. parameters with temperature is formulated. In addition to this study using 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate, there are many other studies that have used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6SDS of cas: 174501-65-6) was used in this study.

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. SDS of cas: 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C7H7N3In 2020 ,《Efficient Synthesis of Pyrimido[1,2-a]Benzimidazoles and Ethyl Pyrimido[1,2-a]Benzimidazole-3-Carboxylates Using Bronsted Acidic Ionic Liquid Supported on Nanoporous Na+-Montmorillonite》 appeared in Polycyclic Aromatic Compounds. The author of the article were Makhsous, Masoumeh; Shirini, Farhad; Seddighi, Mohadeseh; Mazloumi, Masoumeh. The article conveys some information:

Nanoporous sodium montmorillonite clay (Na+-MMT) was successfully modified with 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate (Na+-MMT-[pmim]HSO4). This immobilized acidic ionic liquid showed excellent catalytic activity for the synthesis of pyrimido[1,2-a]benzimidazoles and Et pyrimido[1,2-a]benzimidazole-3-carboxylates via three-component reactions between aldehydes, 2-aminobenzimidazole and malononitrile or β-dicarbonyl compounds The procedure gave the products in high yields in very short reaction times at 100° under solvent-free conditions. Also, this catalyst can be reused for five times without loss of its catalytic activity. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Synthetic Route of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Synthetic Route of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C3H3BrN2In 1993 ,《QSAR’s from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods》 appeared in Journal of Medicinal Chemistry. The author of the article were Good, Andrew C.; Peterson, Stephen J.; Richards, W. Graham. The article conveys some information:

It has recently been shown that good quant. structure-activity relationships can be obtained through statistical anal. of mol. similarity matrixes. Here we extend the technique to seven addnl. mol. series, previously studied using Comparative Mol. Field Anal. (CoMFA) methodol. The results are used to confirm technique applicability across a wider range of QSAR problems and to compare quant. the ability of various similarity indexes to describe biol. systems. The relative merits of this technique in comparison to CoMFA are discussed. In addition to this study using 2-Bromo-1H-imidazole, there are many other studies that have used 2-Bromo-1H-imidazole(cas: 16681-56-4Computed Properties of C3H3BrN2) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Computed Properties of C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7720-39-0In 2017 ,《Enhanced nonenzymatic RNA copying with 2-aminoimidazole activated nucleotides》 was published in Journal of the American Chemical Society. The article was written by Li, Li; Prywes, Noam; Tam, Chun Pong; O’Flaherty, Derek K.; Lelyveld, Victor S.; Izgu, Enver Cagri; Pal, Ayan; Szostak, Jack W.. The article contains the following contents:

Achieving efficient nonenzymic replication of RNA is an important step toward the synthesis of self-replicating protocells that may mimic early forms of life. Despite recent progress, the nonenzymic copying of templates containing mixed sequences remains slow and inefficient. Here we demonstrate that activating nucleotides with 2-aminoimidazole results in superior reaction kinetics and improved yields of primer extension reaction products. This new leaving group significantly accelerates monomer addition as well as trimer-assisted RNA primer extension, allowing efficient copying of a variety of short RNA templates with mixed sequences. In the experiment, the researchers used 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 530-62-1In 2019 ,《Optimized Association of Short Alkyl Side Chains Enables Stiff, Self-Recoverable, and Durable Shape-Memory Hydrogel》 was published in ACS Applied Materials & Interfaces. The article was written by Wang, Shuting; Liu, Mengjuan; Gao, Liang; Guo, Guoqiang; Huo, Yanping. The article contains the following contents:

This work reports a self-healing and shape-memory hydrogel integrating multiple mech. properties. The network configuration is featured as entangled networks cross-linked by distributed association of short alkyl chains (hexyl, six carbons). These crosslinking knots are interconnected by the long hydrophilic polyvinyl alc. backbone. The optimal aggregation of hexyl side chains leads to the broadened distribution in bonding strength as verified by static and dynamic mech. characterization. These structural features contribute to high strength, toughness, stiffness, and yet fast recoverability. Furthermore, the hydrophobic and supramol. nature of aggregated alkyl chains offers high durability and solvent-assistant healing function. Finally, distributed association of hexyl side chains confers a broadened temperature-dependent modulus, allowing for encoding stepwise shape recovery from a temporary shape at different temperatures and/or times. In addition to this study using Di(1H-imidazol-1-yl)methanone, there are many other studies that have used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Related Products of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling》 was written by Lien, Jin-Cherng; Chung, Chi-Li; Huang, Tur-Fu; Chang, Tsung-Chia; Chen, Kuan-Chung; Gao, Ging-Yan; Hsu, Ming-Jen; Huang, Shiu-Wen. Reference of 1H-Benzo[d]imidazol-2-amineThis research focused onumbilical vein endothelial cell 2 aminobenzimidazole Jzu 17 antiangiogenesis. The article conveys some information:

In this study, we aim to characterize the anti-angiogenic mechanisms of a novel 2-aminobenzimidazole-based compound, Jzu 17, in an effort to develop novel angiogenesis inhibitor. Exptl. Approach : Effects of Jzu 17 on endothelial cell proliferation, migration, invasion, and activation of signalling mols. induced by VEGF-A, were analyzed by immunoblotting, MTT, BrdU, migration, and invasion assays. We performed tube formation assay, aorta ring sprouting assay, matrigel plug assay, and a mouse model of metastasis to evaluate ex vivo and in vivo anti-angiogenic effects of Jzu 17. Key Results : Jzu 17 inhibited VEGF-A-induced cell proliferation, migration, invasion, and endothelial tube formation of HUVECs. Jzu 17 suppressed VEGF-A-induced microvessel sprouting ex vivo and attenuated VEGF-A- or tumor cell-induced neovascularization in vivo. Jzu 17 also reduced B16F10 melanoma lung metastasis. In addition, Jzu 17 inhibited the phosphorylation of VEGFR-2 and its downstream signalling mols. in VEGF-A-stimulated HUVECs. Results from computer modeling further showed that Jzu 17 binds to VEGFR-2 with high affinity. Conclusions and Implications : Jzu 17 may inhibit endothelial remodelling and suppress angiogenesis through targeting VEGF-A-VEGFR-2 signalling. These results also suggest Jzu 17 as a potential lead compound and warrant the clin. development of similar agents in the treatment of cancer and angiogenesis-related diseases.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Reference of 1H-Benzo[d]imidazol-2-amine) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Reference of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem