Month: October 2022

The author of 《Ruthenium(II)-Catalyzed Enantioselective γ-Lactams Formation by Intramolecular C-H Amidation of 1,4,2-Dioxazol-5-ones》 were Xing, Qi; Chan, Chun-Ming; Yeung, Yiu-Wai; Yu, Wing-Yiu. And the article was published in Journal of the American Chemical Society in 2019. Formula: C7H6N4O The author mentioned the following in the article:

We report the Ru-catalyzed enantioselective annulation of 1,4,2-dioxazol-5-ones to furnish γ-lactams in up to 97% yield and 98% ee via intramol. carbonylnitrene C-H insertion. By employing chiral diphenylethylene diamine (dpen) as ligands bearing electron-withdrawing arylsulfonyl substituents, the reactions occur with remarkable chemo- and enantioselectivities; the competing Curtius-type rearrangement was largely suppressed. Enantioselective nitrene insertion to allylic/propargylic C-H bonds was also achieved with remarkable tolerance to the C=C and CC bonds. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Formula: C7H6N4O)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Formula: C7H6N4O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Experimental and computational investigation of methane hydrate inhibition in the presence of amino acids and ionic liquids》 were Lee, Dongyoung; Go, Woojin; Seo, Yongwon. And the article was published in Energy (Oxford, United Kingdom) in 2019. Category: imidazoles-derivatives The author mentioned the following in the article:

Amino acids (glycine and alanine) and ionic liquids ([BMIM][BF4] and [BMIM][I]) were examined for their inhibition elects on CH4 hydrates with exptl. and computational approaches. Both amino acids and ionic liquids functioned well as thermodn. hydrate inhibitors, by shifting equilibrium curves of CH4 hydrates toward harsh conditions. However, powder X-ray diffraction patterns indicated that amino acids and ionic liquids did not alect the hydrate structure because they were not included in the hydrate cages due to their large mol. size. Gas uptake measurements showed that the conversion of water into gas hydrates and the formation rates of CH4 hydrate were significantly influenced by inhibitors. D. functional theory calculations indicated that [BMIM][BF4] had a larger potential than glycine to inhibit gas hydrate formation by giving a more neg. interaction energy between a cage and an inhibitor mol. The time-dependent Raman spectra collected during CH4 hydrate formation demonstrated that [BMIM][BF4] hindered CH4 mols. from occupying small (512) cages, whereas glycine had a strong influence on large (51262) cages of sI hydrates. The exptl. and computational results provide a better understanding of inhibition mechanisms of gas hydrates and thus can contribute to the improved control of hydrate formation in oil and gas pipelines. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Category: imidazoles-derivatives)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Position-specific 15N isotope analysis in organic molecules: A high-precision 15N NMR method to determine the intramolecular 15N isotope composition and fractionation at natural abundance》 were Joubert, Valentin; Silvestre, Virginie; Lelievre, Maxime; Ladroue, Virginie; Besacier, Fabrice; Akoka, Serge; Remaud, Gerald S.. And the article was published in Magnetic Resonance in Chemistry in 2019. Application of 616-47-7 The author mentioned the following in the article:

The position-specific 15N isotope content in organic mols., at natural abundance, is for the first time determined by using a quant. methodol. based on 15N NMR spectrometry. 15N NMR spectra are obtained by using an adiabatic “”Full-Spectrum”” INEPT sequence in order to make possible 15N NMR experiments with a high signal-to-noise ratio (>500), to reach a precision with a standard deviation below 1% (0.1%). This level of precision is required for observing small changes in 15N content associated to 15N isotope effects. As an illustration, the measurement of an isotopic enrichment factor ε for each 15N isotopomer is presented for 1-methylimidazole induced during a separation process on a silica column. The precision expressed as the long-term repeatability of the methodol. is good enough to evaluate small changes in the 15N isotope contents for a given isotopomer. As observed for 13C, inverse and normal 15N isotope effects occur concomitantly, giving access to new information on the origin of the 15N isotope effects, not detectable by other techniques such as isotope ratio measured by Mass Spectrometry for which bulk (average) values are obtained. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Application of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Application of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Controlled Synthesis of Co@N-Doped Carbon by Pyrolysis of ZIF with 2-Aminobenzimidazole Ligand for Enhancing Oxygen Reduction Reaction and the Application in Zn-Air Battery》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Zhang, Minghui; Zhang, Erhuan; Hu, Chunyan; Zhao, Yong; Zhang, Han-ming; Zhang, Yijie; Ji, Muwei; Yu, Jiali; Cong, Guangtao; Liu, Huichao; Zhang, Jiatao; Zhu, Caizhen; Xu, Jian. Category: imidazoles-derivatives The article mentions the following:

The Co/N-doped carbon material, as an important electrocatalytic material, has been attracted intense interest in ORR and Zn-air battery. Here, we report an efficient Co@N-doped carbon catalyst (Co@N-C-1) obtained by pyrolysis of ZIF precursor with 2-aminobenzimidazole. The introduction of 2-aminobenzimidazole results in the formation of hierarchical meso/microporous structure of the as-prepared Co@N-C-1, effectively avoiding the aggregation of Co nanoparticles during pyrolysis and the higher N content, which contributes to enhance the ORR electrocatalytic activities. The obtained Co@N-C-1 exhibits remarkable ORR performance with a half-wave potential of 0.938 V vs RHE in alk. media. As the air catalyst of zinc-air batteries, Co@N-C-1 displays 1.439 V of open-circuit voltage and 1413.3 Wh·kg-1 of energy d. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity》 was written by Kankala, Shravankumar; Rama, Koteshwar Rao; Kesari, Chekrapani; Bjorkling, Fredrik; Nerella, Srinivas; Gundepaka, Prasad; Guguloth, Hanmanthu; Thota, Niranjan. Application of 141556-45-8 And the article was included in Synthetic Communications in 2020. The article conveys some information:

A series of fluorophenylpyrazole-picolinamide derivatives were synthesized in high yields using a cross-coupling reaction catalyzed by in-situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). The synthesized novel derivatives were evaluated for in-vitro anticancer activity against a panel of four human tumor cell lines, HeLa (cervical), A-549 (lung), MCF-7 (breast), and IMR-32 (neuroblastoma). Four compounds showed growth inhibition (low μM) comparable with the standard drug cisplatin, provided a preliminary structure-activity relationship for the series. The present procedure was operationally simple and worked with a wide range of substrates and may thus be useful in further compound optimization. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Ion Vacancies and Transport in 1-Methylimidazolium Triflate Organic Ionic Plastic Crystal》 was written by Zhu, Haijin; Forsyth, Maria. Quality Control of 1-Methyl-1H-imidazole And the article was included in Journal of Physical Chemistry Letters in 2020. The article conveys some information:

Organic ionic plastic crystals (OIPCs) are an important family of materials that have shown exciting possibilities as solid electrolytes for lithium ion batteries and other electrochem. devices. In this study we demonstrate for the first time that, although the X-ray shows sharp diffraction peaks, both cation and anion clearly exhibit significant ion diffusion in solid phase I. Two phases with ion diffusivities differing by 2 orders of magnitude can be identified. The populations of the cation and anion in both phases are found to be unequal, hinting at the existence of (neg. charged) cation vacancies in the plastic crystal phase and a pos. charged grain boundary phase. These interesting properties of ion vacancies and unequal populations of cation and anion are likely to be ubiquitous in other OIPCs, and it is of paramount importance to be aware of these features to correctly understand the structure-property relationships of this important material family. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazole(cas: 616-47-7Quality Control of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Quality Control of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《TurboID-based proximity labeling for in planta identification of protein-protein interaction networks》 was written by Zhang, Yongliang; Li, Yuanyuan; Yang, Xinxin; Wen, Zhiyan; Nagalakshmi, Ugrappa; Dinesh-Kumar, Savithramma P.. Synthetic Route of C10H16N2O3S And the article was included in Journal of Visualized Experiments in 2020. The article conveys some information:

Proximity labeling (PL) techniques using engineered ascorbate peroxidase (APEX) or Escherichia coli biotin ligase BirA (known as BioID) have been successfully used for identification of protein-protein interactions (PPIs) in mammalian cells. However, requirements of toxic hydrogen peroxide (H2O2) in APEX-based PL, longer incubation time with biotin (16-24 h), and higher incubation temperature (37°C) in BioID-based PL severely limit their applications in plants. The recently described TurboID-based PL addresses many limitations of BioID and APEX. TurboID allows rapid proximity labeling of proteins in just 10 min under room temperature (RT) conditions. Although the utility of TurboID has been demonstrated in animal models, we recently showed that TurboID-based PL performs better in plants compared to BioID for labeling of proteins that are proximal to a protein of interest. Provided here is a step-by-step protocol for the identification of protein interaction partners using the N-terminal Toll/interleukin-1 receptor (TIR) domain of the nucleotide-binding leucine-rich repeat (NLR) protein family as a model. The method describes vector construction, agroinfiltration of protein expression constructs, biotin treatment, protein extraction and desalting, quantification, and enrichment of the biotinylated proteins by affinity purification The protocol described here can be easily adapted to study other proteins of interest in Nicotiana and other plant species. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Synthetic Route of C10H16N2O3S) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Synthetic Route of C10H16N2O3S And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Proton transfer dynamics in the aprotic proton accepting solvent 1-methylimidazole》 was written by Thomaz, Joseph E.; Walker, Alice R.; Van Wyck, Stephen J.; Meisner, Jan; Martinez, Todd J.; Fayer, Michael D.. Related Products of 616-47-7 And the article was included in Journal of Physical Chemistry B in 2020. The article conveys some information:

The dynamics of proton transfer to the aprotic solvent 1-methylimidazole (MeIm, proton acceptor) from the photoacid 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) was investigated using fast fluorescence measurements. The closely related mol., 8-methoxypyrene-1,3,6-trisulfonic acid trisodium salt (MPTS), which is not a photoacid, was also studied for comparison. Following optical excitation, the wavelength-dependent population dynamics of HPTS in MeIm resulting from the deprotonation process were collected over the entire fluorescence emission window. Anal. of the time-dependent fluorescence spectra revealed four distinct fluorescence bands that appear and decay on different time scales. We label these four states as protonated (P), associated I (AI), associated II (AII), and deprotonated (D). We find that the simple kinetic scheme of P → AI → AII → D is not consistent with the data. Instead, the kinetic scheme that describes the data has P decaying into AI, which mainly goes on to deprotonation (D), but AI can also feed into AII. AII can return to AI or decay to the ground state, but does not deprotonate within exptl. error. Quantum chem. and excited state QM/MM Born-Oppenheimer mol. dynamics simulations indicate that AI and AII are two H-bonding conformations of MeIm to the HPTS hydroxyl, axial, and equatorial, resp. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Related Products of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Related Products of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prasoona, G.; Kishore, B.; Brahmeshwari, G. published their research in Russian Journal of Organic Chemistry in 2021. The article was titled 《A Simple and Efficient Four-Component One-Pot Synthesis of Novel 2-Aryl-3-benzimidazolyl-3,4-dihydroimidazo[4,5-b]indoles Catalyzed by Ceric Ammonium Nitrate in Aqueous Ethanol》.Reference of 1H-Benzo[d]imidazol-2-amine The article contains the following contents:

A simple and efficient protocol for the synthesis of benzimidazolylimidazo[4,5-b]indoles was developed through the condensation of 2-aminobenzimidazoles, aromatic aldehydes, ammonium acetate and isatins via multicomponent reaction strategy using ceric ammonium nitrate as catalyst. The key advantages of the four-component reaction were easy work-up, high yield, short reaction time and environmentally safe solvent. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Reference of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Reference of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gilleran, John A.; Yu, Xin; Blayney, Alan J.; Bencivenga, Anthony F.; Na, Bing; Augeri, David J.; Blanden, Adam R.; Kimball, S. David; Loh, Stewart N.; Roberge, Jacques Y.; Carpizo, Darren R. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Benzothiazolyl and Benzoxazoyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53》.Application of 4857-06-1 The article contains the following contents:

We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc metallochaperones (ZMCs) that restore zinc binding by shuttling zinc into cells. We defined biophys. and cellular assays necessary for structure-activity relationship studies using this mechanism. We investigated an alternative class of zinc scaffolds that differ from TSCs by substitution of the thiocarbamoyl moiety with benzothiazoyl, benzoxazoyl, and benzimidazoyl hydrazones. Members of this series bound zinc with similar affinity and functioned to reactivate mutant p53 comparable to the TSCs. Acute toxicity and efficacy assays in rodents demonstrated C1 to be significantly less toxic than the TSCs while demonstrating equivalent growth inhibition. We identified C85 as a ZMC with diminished copper binding that functions as a chemotherapy and radiation sensitizer. We conclude that the benzothiazoyl, benzoxazoyl, and benzimidazoyl hydrazones can function as ZMCs to reactivate mutant p53 in vitro and in vivo. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Application of 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Application of 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem