Month: October 2022

In 2018,Chaplais, Gerald; Fraux, Guillaume; Paillaud, Jean-Louis; Marichal, Claire; Nouali, Habiba; Fuchs, Alain H.; Coudert, Francois-Xavier; Patarin, Joel published 《Impacts of the Imidazolate Linker Substitution (CH3, Cl, or Br) on the Structural and Adsorptive Properties of ZIF-8》.Journal of Physical Chemistry C published the findings.HPLC of Formula: 16681-56-4 The information in the text is summarized as follows:

Zeolitic Imidazolate Frameworks (ZIFs) represent a thriving subclass of metal-organic frameworks (MOFs) owing to the large variety of their topologies, of which some of them are common with zeolites, and the ability to modulate the chem. of their frameworks as well as the hydrophobicity/hydrophilicity balance, making them perfect examples of the isoreticular chem. concept. One peculiar structural feature of ZIFs is their potential for structural transitions by rotation (or swing) of their linkers under external stimuli (guest adsorption, mech. constraints, etc.). This singular characteristic, often denominated “”swing effect”” or “”gate opening””, is related to flexible ZIFs. Our study focuses on the influence of the functional group (-CH3, -Cl, -Br) borne in position 2 by the imidazolate linker on the flexible/stiff nature of three isoreticular ZIFs with SOD topol. In the first part, we report the structures of ZIF-8_Cl and ZIF-8_Br, two halogenated analogs of the well-known ZIF-8 (herein named ZIF-8_CH3), thanks to synergistic contributions of powder X-ray diffraction and 13C MAS NMR spectroscopy. In both cases, a disorder of the linker is noted and characterized by two quasi-equal occupancies of the two linker subsets in the asym. unit. Exptl. nitrogen sorption measurements, performed at 77 K for the three isoreticular ZIFs, combined with first-principles mol. dynamics simulations bring to light the flexibility of ZIF-8_CH3 and ZIF-8_Cl and the stiffness of ZIF-8_Br.2-Bromo-1H-imidazole(cas: 16681-56-4HPLC of Formula: 16681-56-4) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. HPLC of Formula: 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Molecular Structure included an article by Abdulazeez, Ismail; Khaled, Mazen; Al-Saadi, Abdulaziz A.. Quality Control of 2-Chloro-1H-benzo[d]imidazole. The article was titled 《Impact of electron-withdrawing and electron-donating substituents on the corrosion inhibitive properties of benzimidazole derivatives: A quantum chemical study》. The information in the text is summarized as follows:

The role of substituents in the enhancement of corrosion inhibition effectiveness in some organic compounds has been the subject of several studies in recent years. Understanding the relationship between corrosion inhibition performance and electronic properties of the mol. shall facilitate the design of efficient inhibitors and reduce the burden of exptl. trials involved. In this study, quantum chem. calculations using d. functional theory (DFT) method were performed on benzimidazole and its derivatives involving various electron-withdrawing and electron-releasing substituents. Several reactivity indicators, such as frontier orbitals, energy gaps, electronegativity, electrophilicity and global hardness were calculated and correlated with available exptl. data. Frontier orbital energy gap predicted 2-nitrobenzimidazole to possess higher anti-corrosion properties, while electronegativity, electrophilicity and global hardness predicted 2-aminobenzimidazole to exhibit higher corrosion inhibition tendency. Results of mol. level interaction studies predicted that the adsorption of the mols. over the iron surface would take place preferentially through the nitrogen atoms of the imidazole ring and the carbon atoms of the benzene ring, resulting in the formation of Fe-N and Fe-C bonds with 2.00-2.40 Å bond distances which lie within the range of the chemisorption interaction. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Quality Control of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Quality Control of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Advanced Materials (Weinheim, Germany) included an article by Guo, Jiawei; Li, Dandan; Tao, Hui; Li, Gang; Liu, Renfeng; Dou, Yin; Jin, Taotao; Li, Lanlan; Huang, Jun; Hu, Houyuan; Zhang, Jianxiang. Recommanded Product: Di(1H-imidazol-1-yl)methanone. The article was titled 《Cyclodextrin-derived intrinsically bioactive nanoparticles for treatment of acute and chronic inflammatory diseases》. The information in the text is summarized as follows:

Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation of existing anti-inflammatory therapeutics is that they cannot simultaneously regulate pro-inflammatory cytokine production, oxidative stress, and recruitment of neutrophils and macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacol. activities are synthesized, using a chem. modified cyclic oligosaccharide. The manufacture of this type of bioactive, saccharide material-based NPs (defined as LCD NP) is straight forward, cost-effective, and scalable. Functionally, LCD NP effectively inhibits inflammatory response, oxidative stress, and cell migration for both neutrophils and macrophages, two major players of inflammation. Therapeutically, LCD NP shows desirable efficacies for the treatment of acute and chronic inflammatory diseases in mouse models of peritonitis, acute lung injury, and atherosclerosis. Mechanistically, the therapeutic benefits of LCD NP are achieved by inhibiting neutrophil-mediated inflammatory macrophage recruitment and by preventing subsequent pro-inflammatory events. In addition, LCD NP shows good safety profile in a mouse model. Thus, LCD NP can serve as an effective anti-inflammatory nanotherapy for the treatment of inflammatory diseases mainly associated with neutrophil and macrophage infiltration. In addition to this study using Di(1H-imidazol-1-yl)methanone, there are many other studies that have used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: Di(1H-imidazol-1-yl)methanone) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Iridium-Catalyzed Enantioselective C(sp3)-H Amidation Controlled by Attractive Noncovalent Interactions》 were Wang, Hao; Park, Yoonsu; Bai, Ziqian; Chang, Sukbok; He, Gang; Chen, Gong. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 530-62-1 The author mentioned the following in the article:

While remarkable progress was made over the past decade, new design strategies for chiral catalysts in enantioselective C(sp3)-H functionalization reactions are still highly desirable. In particular, the ability to use attractive noncovalent interactions for rate acceleration and enantiocontrol would significantly expand the current arsenal for asym. metal catalysis. Herein, the authors report the development of a highly enantioselective Ir(III)-catalyzed intramol. C(sp3)-H amidation reaction of dioxazolone substrates for synthesis of optically enriched γ-lactams using a newly designed α-amino-acid-based chiral ligand. This Ir-catalyzed reaction proceeds with excellent efficiency and with outstanding enantioselectivity for both activated and unactivated alkyl C(sp3)-H bonds under very mild conditions. It offers the first general route for asym. synthesis of γ-alkyl γ-lactams. Water is a unique cosolvent to achieve excellent enantioselectivity for γ-aryl lactam production Mechanistic studies revealed that the ligands form a well-defined groove-type chiral pocket around the Ir center. The hydrophobic effect of this pocket allows facile stereocontrolled binding of substrates in polar or aqueous media. Instead of capitalizing on steric repulsions as in the conventional approaches, this new Ir catalyst operates through an unprecedented enantiocontrol mechanism for intramol. nitrenoid C-H insertion featuring multiple attractive noncovalent interactions. The results came from multiple reactions, including the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Synthesis of Imidazolium and Benzimidazolium Triiodides》 were Shagun, L. G.; Dorofeev, I. A.; Zhilitskaya, L. V.; Yarosh, N. O.; Larina, L. I.. And the article was published in Russian Journal of Organic Chemistry in 2019. Name: 1H-Benzo[d]imidazol-2-amine The author mentioned the following in the article:

1,3-(Di)acetonylimidazolium and -benzimidazolium triiodides were synthesized in a one-pot fashion by reactions of imidazole, 3-(1H-imidazol-4-yl)prop-2-enoic acid, benzimidazole, benzimidazol-2-amine, and 2-ethylbenzimidazole with 1-iodopropan-2-one and mol. iodine under solvent-free conditions in the absence of a base and catalyst at room temperature The reaction of 1H-benzimidazole-2-thiol with 1-iodopropan-2-one and iodine afforded 2-(2-oxopropylsulfanyl)imidazolium triiodide. The reaction direction and yield did not change when 2-iodo-1-(thiophen-2-yl)ethanone was used instead of 1-iodopropan-2-one. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Name: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Name: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors》 were Deaton, David N.; Do, Young; Holt, Jason; Jeune, Michael R.; Kramer, H. Fritz; Larkin, Andrew L.; Orband-Miller, Lisa A.; Peckham, Gregory E.; Poole, Chuck; Price, Daniel J.; Schaller, Lee T.; Shen, Ying; Shewchuk, Lisa M.; Stewart, Eugene L.; Stuart, J. Darren; Thomson, Stephen A.; Ward, Paris; Wilson, Joseph W.; Xu, Tianshun; Guss, Jeffrey H.; Musetti, Caterina; Rendina, Alan R.; Affleck, Karen; Anders, David; Hancock, Ashley P.; Hobbs, Heather; Hodgson, Simon T.; Hutchinson, Jonathan; Leveridge, Melanie V.; Nicholls, Harry; Smith, Ian E. D.; Somers, Don O.; Sneddon, Helen F.; Uddin, Sorif; Cleasby, Anne; Mortenson, Paul N.; Richardson, Caroline; Saxty, Gordon. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Application of 7720-39-0 The author mentioned the following in the article:

With the goal of discovering more selective anti-inflammatory drugs than COX inhibitors, to attenuate prostaglandin signaling, a fragment-based screen of hematopoietic prostaglandin D synthase was performed. The 76 crystallog. hits were sorted into similar groups, with the 3-cyano-quinoline 1a(I) (FP IC50 = 220,000 nM, LE = 0.43) being a potent member of the 6,6-fused heterocyclic cluster. Employing SAR insights gained from structural comparisons of other H-PGDS fragment binding mode clusters, the initial hit I was converted into the 70-fold more potent quinoline 1d(II) (IC50 = 3,100 nM, LE = 0.49). A systematic substitution of the amine moiety of II, utilizing structural information and array chem., with modifications to improve inhibitor stability, resulted in the identification of the 300-fold more active H-PGDS inhibitor tool compound 1bv(III) (IC50 = 9.9 nM, LE = 0.42). This selective inhibitor exhibited good murine pharmacokinetics, dose-dependently attenuated PGD2 production in a mast cell degranulation assay and should be suitable to further explore H-PGDS biol.1H-Imidazol-2-amine(cas: 7720-39-0Application of 7720-39-0) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Application of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《The effect of nanoconfinement on the glass transition temperature of ionic liquids》 were Zuo, Yuchen; Zhang, Yuanzhong; Huang, Rundong; Min, Younjin. And the article was published in Physical Chemistry Chemical Physics in 2019. Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate The author mentioned the following in the article:

This work is concerned with investigating the glass transition behavior of ionic liquids as a function of nanoconfinement. The glass transition temperature was found to increase with a decrease in confinement length, below a critical confinement of 40-50 nm and 80-90 nm for 1-butyl-3-methylimidazolium tetrafluoro-borate and 1-methyl-3-octylimidazolium tetrafluoro-borate between alumina surfaces, resp. In the experimental materials used by the author, we found 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Effects of water on ionic liquid electrochemical microsensor for oxygen sensing》 were Liu, Xiaojun; Chen, Xiaoyu; Xu, Yong; Chen, Tongtong; Zeng, Xiangqun. And the article was published in Sensors and Actuators, B: Chemical in 2019. COA of Formula: C8H15BF4N2 The author mentioned the following in the article:

The effect of water on ionic liquid (IL) planar electrochem. microsensor was studied in the case of sensing oxygen. This study compared the key anal. performances of the IL based electrochem. microsensor devices using an IL BmimBF4 direct from the vendor and ‘wet’ BmimBF4 containing different amount of water as electrolytes. The electrochem. properties in [Bmim][BF4] with or without oxygen using a planar microsensor device were characterized by cyclic voltammetry (CV) and electrochem. impedance spectroscopy (EIS). With the increasing of water concentrations in the IL, a pos. shift of redox potential of O2 and a higher reduction current of oxygen in CV measurement were observed The constant potential chronoamperometry measurements were conducted to assess the sensitivity, reproducibility and stability of microsensor at varying O2 concentration using these wet ILs as electrolytes. The short term and long-term stability evaluation of these IL microsensor for sensing oxygen was performed. Our results show that the electrochem. planar microsensor device demonstrates a good sensitivity, reproducibility and stability for sensing oxygen even though the ‘wet’ ILs were used as electrolytes. A remarkable stability of sensor was observed in stability test using as an electrolyte. In the experiment, the researchers used many compounds, for example, 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem