Month: October 2022

Mergehenn, R.; Haase, W.; Allmann, R. published the artcile< Crystal structures of chloro- and γ-bromo-(2-dibutylaminoethanolato)copper(II)>, Related Products of 1003-21-0, the main research area is mol structure copper aminoethanolato halo; chloro copper aminoethanolato structure; bromo copper aminoethanolato structure.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. The crystal structures of halo-(2-dibutylaminoethanolato)copper(II) [(C10H22NOCuX)4, X = Cl (I), Br (II) were determined by single-crystal x-ray diffractometer methods using 4331 and 3915 independent reflections, resp., from 3-dimensional diffractometer data (Mo Ka radiation). The isomorphous compounds belong to space group P1̅ with a 15·563(10), b 16·280(11), c 11·659(8) Å, α 93·49(10), β 100·32(10), γ 112·51(10)° for I and a 15·539(10), b 16·452(11), c 11·766(8) Å, α 94·58(10), β 100·65(10), γ 111·67(10)° for II. The structures were refined by least-squares methods to final residuals of 0.084 and 0.071, resp. The tetrameric clusters of cubane-type mol. structures have mean Cu-Cu separations of 3·240(3) and 3·268(3) Å. The Cu coordination is distorted square pyramidal with Cu bonded to 3 O, 1N, and 1 halogen. The distance to the apical O is longer than to the other 2 O. The average bond lengths are Cu-O 1·9778) and 1·963(10) Å (short Cu-O separations), Cu-O 2·424(8) and 2·480(10) Å (long-Cu-O separations), Cu-N 2·054(11) and 2·066(13) Å, and Cu-hal 2·234(4) and 2·382(3) Å.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry published new progress about Crystal structure. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

G-Dayanandan, Narendran; Scocchera, Eric W.; Keshipeddy, Santosh; Jones, Heather F.; Anderson, Amy C.; Wright, Dennis L. published the artcile< Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks>, Electric Literature of 1003-21-0, the main research area is aryl propyne preparation reduction substitution arylalkynyl carbinol.

To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereby nucleophilic addition of acetylene to aryl carboxaldehydes would be followed by reduction or substitution of the resulting propargyl alc. The direct reduction, methylation, and dimethylation of these readily available alcs. provide efficient access to this uncommon functional array. In addition, an unusual silane exchange reaction was observed in the reduction of the propargylic alcs.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Electric Literature of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Salvitti, Chiara; Bortolami, Martina; Chiarotto, Isabella; Troiani, Anna; de Petris, Giulia published the artcile< The Knoevenagel condensation catalysed by ionic liquids: a mass spectrometric insight into the reaction mechanism>, HPLC of Formula: 700370-07-6, the main research area is anisaldehyde cyanoacetate methylimidazolium chloride Knoevenagel condensation mechanism.

The creation of carbon-carbon bonds is still a highly required topic in organic chem. for the capacity to give a wide variety of new products of industrial value. Accordingly, the Knoevenagel condensation between activated methylene compounds and aldehydes is one of the most known carbon coupling reactions. In this work, the catalytic activity of imidazolium-based ionic liquids (1-butyl-3-methylimidazolium acetate, 1-butyl-3-methylimidazolium chloride, 1-methyl-3-carboxymethylimidazolium chloride) was studied under solvent-free conditions and compared with that of sodium salts (sodium chloride, sodium acetate). Mass spectrometric techniques were used to monitor the formation of the reaction products and to detect the key intermediates of the process. Based on the catalyst employed different reaction mechanisms were highlighted, thus laying the foundation for the design of more specific and efficient catalysts.

New Journal of Chemistry published new progress about Electrospray ionization mass spectrometry. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, HPLC of Formula: 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Klein, Hannah L.; Ang, Kenny K. H.; Arkin, Michelle R.; Beckwitt, Emily C.; Chang, Yi-Hsuan; Fan, Jun; Kwon, Youngho; Morten, Michael J.; Mukherjee, Sucheta; Pambos, Oliver J.; el Sayyed, Hafez; Thrall, Elizabeth S.; Vieira-da-Rocha, Joao P.; Wang, Quan; Wang, Shuang; Yeh, Hsin-Yi; Biteen, Julie S.; Chi, Peter; Heyer, Wolf-Dietrich; Kapanidis, Achillefs N.; Loparo, Joseph J.; Strick, Terence R.; Sung, Patrick; Van Houten, Bennett; Niu, Hengyao; Rothenberg, Eli published the artcile< Guidelines for DNA recombination and repair studies: mechanistic assays of DNA repair processes>, Category: imidazoles-derivatives, the main research area is aminopurine DNA recombination repair mutagenesis review; DNA breaks; DNA helicases; DNA repair centers; DNA repair synthesis; DNA resection; DSBs; FRET; PALM; chromatin dynamics; chromosome rearrangements; crossovers; double strand break repair; endonuclease protection assay; fluorescent proteins; genome instability; gross chromosome rearrangements; homologous recombination; mismatch repair; nonhomologous end joining; nucleotide excision repair; photoactivated fluorescent proteins; recombinase filament assembly; single-molecule; single-particle tracking; structure-selective endonucleases; super resolution; synthesis-dependent strand annealing; transcription coupled repair.

A review. Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytol. studies that detect changes at the single-cell level. Single mol. assays, which are reviewed here, can detect transient intermediates and dynamics of events. Biochem. assays allow detailed investigation of the DNA and protein activities of each step in a repair, recombination or mutagenesis event. Each type of assay is a powerful tool but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.

Microbial Cell published new progress about DNA repair. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Elsheikh, A. A.; Braun, L. J.; Mansour, S. M. G.; Orabi, A.; Alqahtani, A. S.; Benfield, D. A.; Chase, C. C. L. published the artcile< The effect of human interferon alpha on replication of different bovine viral diarrhea virus strains>, Formula: C5H5N5, the main research area is interferon alpha bovine viral diarrhea virus replication.

In the present study, we evaluated the comparative effect of exogenous human IFN-α (HuIFN-α) on different BVDV biotypes and genotypes. The results showed that exogenous HuIFN-α greatly inhibited the growth of different BVDV biotypes and genotypes. However, HuINF-α has a significant inhibitory effect on cp biotype compared to ncp one without significant variation between different genotypes. The effect of HuIFN-α on BVDV reached the maximum level at early stages of infection (0-20 h post infection) and increased in a dose-dependent manner (10-500 U/mL). Quant. realtime RT-PCR was used to evaluate the effect of exogenous HuIFN-α on RNA synthesis of both BVDV biotypes. HuIFN-α reduced RNA production of cp by 4 logs compared to only 2 logs for ncp strains. Addnl., the antiviral effect of IFN-α against both BVDV biotypes seems to be independent of the RNA-dependent protein kinase (PKR) activation as assayed by direct anal. of in vivo phosphorylation of eIF2-α and by 2-aminopurine (2-AP) treatment. Collectively, these results indicated that the exogenous HuIFN-α treatment has an inhibitory effect not only on cp BVDV biotype but also on the ncp BVDV. The antiviral effect of exogenous HuIFN-α was biotype, time, dose but not genotype dependent. PKR has no role in the inhibitory effect suggesting that other IFN-antiviral pathways were involved.

Acta Virologica (English Edition) published new progress about Bovine diarrhea virus. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Formula: C5H5N5.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vitale, Paola; D’Anna, Francesca; Ferrante, Francesco; Rizzo, Carla; Noto, Renato published the artcile< π-Conjugated diimidazolium salts: rigid structure to obtain organized materials>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is pi conjugated diimidazolium salt organized material.

Phenylene ethynylene based diimidazolium salts differing in the alkyl chain length borne on the imidazolium ion and anion nature were synthesized. Their properties were studied both in solution and in the solid state. Salts obtained were able to aggregate in organic solvent solution Aggregate formation was studied by performing concentration dependent measurements using UV-vis, fluorescence and Resonance Light Scattering. Furthermore, features of the aggregates were also investigated in the solid state by means of fluorescence and SEM measurements. Finally, D. Functional Theory calculations were performed to obtain insights into the interaction geometry in the salts investigated. Data collected evidence that aggregation processes are affected by a combined action of different factors derived from the nature of the salt and solvent. The above features also influence the morphol. of the aggregates as well as the ability of their thin films to give blue emission. On the whole, information gained could represent a useful starting point for applications of these salts in the optoelectronic field among others.

Physical Chemistry Chemical Physics published new progress about Aggregation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcile< Imidazole series. XV. Reaction products of N,N'-dimethyloxamide with pentahalo phosphorus compounds>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is .

14660a. Heating 2 kg. PCl5 with 550 g. (CONHMe)2 1-1.5 hrs. at 95-8° (exothermic initially), followed by further 1.6 hrs. after cessation of exothermic reaction, gave 50.6% 1-methyl-5-chloroimidazole, b9 84°, b10 87°, n22D 1.5120 (picrate m. 167-8°), unreacted amide, and 1-methyl-4,5-dichloroimidazole, m. 58.5-59° (picrate m. 130.5-1.5°; HCl salt m. 161-3°; nitrate m. 122°; sulfate m. 83-5°). Similar reaction of 11.6 g. (CONHMe)2 with 91.6 g. PCl5 and 250 ml. POCl3 in 0.5 hr. at 40-50°, then 1.5 hrs. at 100°, gave a low yield of 1-methyl-2,4,5-trichloroimidazole, m. 75.5-6° (petr. ether), 1-methyl-4,5-dichloroimidazole, isolated as the picrate, and 1-methyl-5-chloroimidazole. Heating 104 g. PBr5 with 14 g. (CONHMe)2 2.1 hrs. on a steam bath gave 19.6% 1-methyl-4,5-dibromoimidazole, m. 79-80° (picrate m. 149.5-50.5°), and 1-methyl-5-bromoimidazole, isolated as the picrate, m. 190-1°. Nitration of the mixed crude mono- and dibromo derivatives with mixed acid 2 hrs. at 100° gave 1-methyl-4-nitro-5-bromoimidazole, m. 180-1°. Heating (CONHMe)2 with PBr5 in POCl3 in 1 hr. at 60-70° and 2 hrs. at reflux gave 1-methyl-2,4,5-tribromoimidazole, m. 93-4°, 1-methyl-4,5-dibromoimidazole, and 1-methyl-5-bromoimidazole, isolated as the picrate.

Zhurnal Obshchei Khimii published new progress about Group 15 element halides, phosphorus halides. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lu, Chang; Jimmy Huang, Po-Jung; Zheng, Jingkai; Liu, Juewen published the artcile< A 2-Aminopurine Fluorescence Spectroscopy for Probing a Glucose Binding Aptamer>, Product Details of C5H5N5, the main research area is aminopurine fluorescence spectroscopy glucose aptamer; aptamers; biosensors; diabetes; fluorescence; glucose.

Glucose is the most important analyte for biosensors. Recently a DNA aptamer was reported allowing binding-based detection. However, due to a relatively weak binding affinity, it is difficult to perform binding assays to understand the property of this aptamer. In this work, we replaced the only adenine base in the aptamer binding pocket with a 2-aminopurine (2AP) and used fluorescence spectroscopy to study glucose binding. In the selection buffer, glucose increased the 2AP fluorescence with a Kd of 15.0 mM glucose, which was comparable with the 10 mM Kd previously reported using the strand displacement assay. The binding required two Na+ ions or one Mg2+ that cannot be replaced by Li+ or K+. The binding was weaker at higher temperature and its vant Hoff plot indicated enthalpy-driven binding. While other monosaccharides failed to achieve saturated binding even at high concentrations, two glucose-containing disaccharides, namely trehalose and sucrose, reached a similar fluorescence level as glucose although with over 10-fold higher Kd values. Detection limits in both the selection buffer (0.9 mM) and in artificial interstitial fluids (6.0 mM) were measured.

ChemBioChem published new progress about Aptamers. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Product Details of C5H5N5.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Xianming; Wang, Yanying; Tang, Honghu; Yang, Bing; Zhao, Yi; Wu, Peng published the artcile< Evaluation of the sequence-dependent relative activity of APE1 for optimal biosensing design>, HPLC of Formula: 452-06-2, the main research area is biosensor APE1 uracil DNA glycosylase fluorescence; APE1; Biosensor sensign; Key bases; Sequence-dependent realtive activity.

Apurinic/apyrimidinic endonuclease 1 (APE1) can selectively incise the AP site of DNA, thus is universal for various DNA substrates for flexible endonuclease-assisted signal amplification. However, the substrate preference of APE1 has never been systematically investigated. Therefore in this work, the detailed sequence-dependent relative activity of APE1 was determined It turned out that the APE1 activity did vary with the change of the adjacent and opposite bases, and over 10-fold relative activity difference was observed for different sequence combinations. Such difference is appreciable enough to induce evident impact on APE1-involved biosensing. With an APE1 probe designed for cycled signal amplification, the sensitivities followed exactly with the above activity order. Compared with Nb.BbvCl, the sensitivity of the APE1 probe varied between higher and lower than the Nb. BbvCl probe (with varied substrates), demonstrating the importance of the sequence-dependent relative activity of APE1 for optimal biosensor development. Moreover, the above APE1 probe design was harvested and engineered for sensitive biosensing of uracil-DNA glycosylase (UDG). Through theor. anal. of the interaction between APE1 and the substrates, the accuracy of the determined sequence-dependent relative activity of APE1 was partially confirmed.

Biosensors & Bioelectronics published new progress about Biosensors. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, HPLC of Formula: 452-06-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sasaki, Shogo; Ma, Yue; Ishizuka, Takumi; Bao, Hong-Liang; Hirokawa, Takatsugu; Xu, Yan; Tera, Masayuki; Nagasawa, Kazuo published the artcile< Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex>, Recommanded Product: 7H-Purin-2-amine, the main research area is telomeric G quadruplex linear consecutive hexaoxazole anti parallel topol.

G-quadruplex structures (G4s) in guanine-rich regions of DNA play critical roles in various biol. phenomena, including replication, translation, and gene expression. There are three types of G4 topol., i.e., parallel, anti-parallel, and hybrid, and ligands that selectively interact with or stabilize a specific topol. have been extensively explored to enable studies of topol.-related functions. Here, we describe the synthesis of a new series of G4 ligands based on 6LCOs (6-linear consecutive oxazoles), i.e., L2H2-2M2EA-6LCO (2), L2A2-2M2EAc-6LCO (3), and L2G2-2M2EG-6LCO (4), which bear four aminoalkyl, acetamidealkyl, and guanidinylalkyl side chains, resp. Among them, ligand 2 stabilized telomeric G4 and induced anti-parallel topol. independently of the presence of cations. The anti-parallel topol. induced by 2 was identified as chair-type by means of 19F NMR spectroscopy and fluorescence experiments with 2-aminopurine-labeled DNA.

RSC Advances published new progress about DNA replication. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Recommanded Product: 7H-Purin-2-amine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem