Month: October 2022

COA of Formula: C8H15BF4N2In 2020 ,《Effects of Surface Transition and Adsorption on Ionic Liquid Capacitors》 was published in Journal of Physical Chemistry Letters. The article was written by Chao, Huikuan; Wang, Zhen-Gang. The article contains the following contents:

Room-temperature ionic liquids (RTILs) are synthetic electrolytes with electrochem. stability superior to that of conventional aqueous-based electrolytes, allowing a significantly enlarged electrochem. window for application as capacitors. In this study, we propose a variant of an existing RTIL model for solvent-free RTILs, accounting for both ion-ion correlations and nonelectrostatic interactions. Using this model, we explore the phenomenon of spontaneous surface charge separation in RTIL capacitors and find that this transition is a common feature for realistic choices of the model parameters in most RTILs. In addition, we investigate the effects of asym. preferential ion adsorption on this charge separation transition and find that proximity of the transition in this case can result in greatly enhanced energy storage. Our work suggests that differential chem. treatment of electrodes can be a simple and useful means for optimizing energy storage in RTIL capacitors. The experimental process involved the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window》 was written by Zhang, Zhiyue; Li, Hui; Kasmi, Sabah; Van Herck, Simon; Deswarte, Kim; Lambrecht, Bart N.; Hoogenboom, Richard; Nuhn, Lutz; De Geest, Bruno G.. Reference of Di(1H-imidazol-1-yl)methanoneThis research focused onUCST polymer hydroxypropylmethacrylamide stimulus responsive biomaterial sustained release; UCST; degradable polymers; gels; protein delivery; responsive polymers. The article conveys some information:

Interactive materials that can respond to a trigger by changing their morphol., but that can also gradually degrade into a fully soluble state, are attractive building blocks for the next generation of biomaterials. Herein, we design such transiently responsive polymers that exhibit UCST behavior while gradually losing this property in response to a hydrolysis reaction in the polymer side chains. The polymers operate within a physiol. relevant window in terms of temperature, pH, and ionic strength. Whereas such behavior has been reported earlier for LCST systems, it is at present unexplored for UCST polymers. Furthermore, we demonstrate that, in contrast to LCST polymers, in aqueous medium the UCST polymer forms a coacervate phase below the UCST, which can entrap a hydrophilic model protein, as well as a hydrophobic dye. Because of their non-toxicity, we also provide in vivo proof of concept of the use of this coacervate as a protein depot, in view of sustained-release applications. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Reference of Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Reference of Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Development of a multistep, electrochemical flow platform for automated catalyst screening》 was written by Schotten, Christiane; Manson, Jamie; Chamberlain, Thomas W.; Bourne, Richard A.; Nguyen, Bao N.; Kapur, Nik; Willans, Charlotte E.. COA of Formula: C21H25ClN2This research focused ontriazole electrochem catalyst copper electrode. The article conveys some information:

The development of an integrated multistep flow platform that incorporates high-throughput electrochem. synthesis of metal catalysts and catalysis screening is described. Ligand libraries can be screened through the implementation of an autosampler, and online HPLC anal. facilitates continuous monitoring of the reaction. The equipment is controlled via a computer which enables the process to be automated, with the platform running ligand/catalysis screens autonomously. The platform has been validated using a ubiquitous Cu-NHC catalyzed click reaction, with conditions chosen so that the reaction does not run at full conversion, which allows the effect of different ligand precursors to be observed An efficient cleaning step is crucial to the reproducibility of reactions, and alternating polarity ensures the long-term stability of the electrochem. reactor. This technol. will enable the profiling of catalysts in continuous systems and accelerate the process of developing more sustainable base-metal catalysts in manufacturing processes. The experimental process involved the reaction of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8COA of Formula: C21H25ClN2)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.COA of Formula: C21H25ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Simple Synthetic Routes to Carbene-M-Amido (M = Cu, Ag, Au) Complexes for Luminescence and Photocatalysis Applications》 was written by Tzouras, Nikolaos V.; Martynova, Ekaterina A.; Ma, Xinyuan; Scattolin, Thomas; Hupp, Benjamin; Busen, Hendrik; Saab, Marina; Zhang, Ziyun; Falivene, Laura; Pisano, Gianmarco; Van Hecke, Kristof; Cavallo, Luigi; Cazin, Catherine S. J.; Steffen, Andreas; Nolan, Steven P.. Recommanded Product: Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) And the article was included in Chemistry – A European Journal on August 16 ,2021. The article conveys some information:

The development of novel and operationally simple synthetic routes to carbene-metal-amido (CMA) complexes [(NHC)M(Cbz)] (NHC = substituted 2-imidazolylidene; HCbz = 9H-carbazole; M = Cu, Ag, Au) of copper, silver and gold relevant for photonic applications are reported. A mild base and sustainable solvents allow all reactions to be conducted in air and at room temperature, leading to high yields of the targeted compounds even on multigram scales. The effect of various mild bases on the N-H metalation was studied in silico and exptl., while a mechanochem., solvent-free synthetic approach was also developed. Our photophys. studies on [M(NHC)(Cbz)] indicate that the occurrence of fluorescent or phosphorescent states is determined primarily by the metal, providing control over the excited state properties. Consequently, we demonstrate the potential of the new CMAs beyond luminescence applications by employing a selected CMA as a photocatalyst. The exemplified synthetic ease is expected to accelerate the applications of CMAs in photocatalysis and materials chem. After reading the article, we found that the author used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Recommanded Product: Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I))

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Recommanded Product: Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Simple Synthetic Routes to N-Heterocyclic Carbene Gold(I)-Aryl Complexes: Expanded Scope and Reactivity》 was written by Tzouras, Nikolaos V.; Saab, Marina; Janssens, Wim; Cauwenbergh, Thibault; Van Hecke, Kristof; Nahra, Fady; Nolan, Steven P.. Category: imidazoles-derivatives And the article was included in Chemistry – A European Journal on April 28 ,2020. The article conveys some information:

Transmetalation of arylboronic acids with gold(I) NHC chlorides [LAuCl] afforded arylgold complexes [LAuAr] (Ar = substitutted Ph, 1-naphthyl, 2-furyl; L = 1,3-bis(diisopropylphenyl)-2-imidazolylidene, 4,5-dichloro-1,3-bis(diisopropylphenyl)-2-imidazolylidene, 1,3-di-1-adamantyl-2-imidazolylidene, 1,3-di-tert-butyl-2-imidazolylidene, PPh3). Reactivity of arylgold complexes [LAuAr] towards OH-, NH- and CH-acids (HX) was explored, giving access to complexes [LAuX]. The discovery of sustainable and scalable synthetic protocols leading to gold-aryl compounds bearing N-heterocyclic carbene (NHC) ligands sparked an investigation of their reactivity and potential utility as organometallic synthons. The use of a mild base and green solvents provide access to these compounds, starting from widely available boronic acids and various [Au(NHC)Cl] complexes, with reactions taking place under air, at room temperature and leading to high yields with unprecedented ease. One compound, (N,N’-bis[2,6-(diisopropyl)phenyl]-2-imidazolylidene)(4-methoxyphenyl)gold, ([Au(IPr)(4-MeOC6H4)]), was synthesized on a multigram scale and used to gauge the reactivity of this class of compounds towards C-H/N-H bonds and with various acids, revealing simple pathways to gold-based species that possess attractive properties as materials, reagents and/or catalysts. In the experiment, the researchers used many compounds, for example, Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Category: imidazoles-derivatives)

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Category: imidazoles-derivatives Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemistry – A European Journal included an article by Rottschaefer, Dennis; Sharma, Mahendra K.; Neumann, Beate; Stammler, Hans-Georg; Andrada, Diego M.; Ghadwal, Rajendra S.. Quality Control of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride. The article was titled 《A Modular Access to Divinyldiphosphenes with a Strikingly Small HOMO-LUMO Energy Gap》. The information in the text is summarized as follows:

The olefinic C-H bond functionalization of (NHC)CHPh (NHC = IPr =C{(NAr)CH}2 1; SIPr = C{(NAr)CH2}2 2; Ar = 2,6-iPr2C6H3), derived from classical N-heterocyclic carbenes (NHCs), with PCl3 affords the dichlorovinylphosphines {(NHC)C(Ph)}PCl2 (NHC = IPr 3, SIPr 4). Two-electron reduction of 3 and 4 with magnesium leads to the formation of the divinyldiphosphenes [{(NHC)C(Ph)}P]2 (NHC = IPr 5, SIPr 6) as crystalline solids. Unlike literature-known diphosphenes, which are mostly yellow or orange, 5 is a green whereas 6 is a purple solid. Although the P:P bond lengths of 5 (2.062(1)) and 6 (2.055(1) Å) are comparable to those of the known diphosphenes (2.02-2.08 Å), the C-P bond lengths of 5 (1.785(1)) and 6 (1.797(1) Å) are, however, considerably shorter than a Csp2-P single bond length (1.85 Å), indicating a considerable π-conjugation between C:C and P:P moieties. The HOMO-LUMO energy gap for 5 (4.15) and 6 (4.52 eV) is strikingly small and thus the narrowest among the diphosphenes (>4.93 eV) reported as yet. Consequently, 5 readily undergoes P:P bond cleavage at room temperature on treatment with sulfur to form the unique dithiophosphorane {(IPr)C(Ph)}P(S)2 7. Interestingly, reaction of 5 with selenium gives the selenadiphosphirane [{(IPr)C(Ph)}P]2Se 8 with an intact P-P bond. In the experimental materials used by the author, we found 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Quality Control of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Quality Control of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chlorideIn addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2010,Garton, Neil; Bailey, Nick; Bamford, Mark; Demont, Emmanuel; Farre-Gutierrez, Irene; Hutley, Gail; Bravi, Gianpaolo; Pickering, Paula published 《Discovery of biaryl inhibitors of H+/K+ ATPase》.Bioorganic & Medicinal Chemistry Letters published the findings.Synthetic Route of C3H3BrN2 The information in the text is summarized as follows:

We report the identification of a novel biaryl template for H+/K+ ATPase inhibition. Evaluation of critical SAR features within the biaryl imidazole framework and the use of pharmacophore modeling against known imidazopyridine and azaindole templates suggested that the geometry of the mol. is key to achieving activity. Herein we present our work optimizing the potency of the mol. through modifications and substitutions to each of the ring systems. In particular sub-micromolar potency is achieved with (4b) presumably through a proposed intramol. hydrogen bond that ensures the required imidazole basic center is appropriately located. In the experiment, the researchers used many compounds, for example, 2-Bromo-1H-imidazole(cas: 16681-56-4Synthetic Route of C3H3BrN2)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Synthetic Route of C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Draughn, G. Logan; Allen, C. Leigh; Routh, Patricia A.; Stone, Maria R.; Kirker, Kelly R.; Boegli, Laura; Schuchman, Ryan M.; Linder, Keith E.; Baynes, Ronald E.; James, Garth; Melander, Christian; Pollard, Angela; Cavanagh, John published 《Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections》.Drug Design, Development and Therapy published the findings.Quality Control of 1H-Imidazol-2-amine The information in the text is summarized as follows:

2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacol. studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of H10 on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that H10 represents a promising lead dermal adjuvant compound The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Abdellattif, Magda H.; Eissa, A. M. F.; Mohamed, H. M. published 《Synthesis of anionic surface active agents containing heterocyclic moiety from long chain fatty alcohols》.Journal of Advances in Chemistry published the findings.Safety of 1H-Imidazol-2-amine The information in the text is summarized as follows:

A series of novel groups of anionic surface active agent were synthesized. Synthesis of these surfactants via the reaction of long chain fatty alcs. (octyl, decyl and dodecyl) with maleic anhydride to give monoester. The monoester chloride reacted with amino derivatives of heterocyclic rings followed by addition of NaHSO3. The surface tension, interfacial tension; Kraft point, emulsifying and wetting power were evaluated. Stability to hydrolysis, biodegradability and biol. activities were measured. A comparison studies between the chem. structures and the results were done. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Safety of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Label-free detection of exosomes using a surface plasmon resonance biosensor》 were Sina, Abu Ali Ibn; Vaidyanathan, Ramanathan; Wuethrich, Alain; Carrascosa, Laura G.; Trau, Matt. And the article was published in Analytical and Bioanalytical Chemistry in 2019. Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid The author mentioned the following in the article:

The development of a sensitive and specific detection platform for exosomes is highly desirable as they are believed to transmit vital tumor-specific information (mRNAs, microRNAs, and proteins) to remote cells for secondary metastasis. Herein, the authors report a simple method for the real-time and label-free detection of clin. relevant exosomes using a surface plasmon resonance (SPR) biosensor. The authors’ method shows high specificity in detecting BT474 breast cancer cell-derived exosomes particularly from complex biol. samples (e.g. exosome spiked in serum). This approach exhibits high sensitivity by detecting as low as 8280 exosomes/μL which may potentially be suitable for clin. anal. The authors believe that this label-free and real-time method along with the high specificity and sensitivity may potentially be useful for clin. settings. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem