Month: October 2022

《Ni(COD)(DQ): An Air-Stable 18-Electron Nickel(0)-Olefin Precatalyst》 was written by Tran, Van T.; Li, Zi-Qi; Apolinar, Omar; Derosa, Joseph; Joannou, Matthew V.; Wisniewski, Steven R.; Eastgate, Martin D.; Engle, Keary M.. Related Products of 258278-25-0 And the article was included in Angewandte Chemie, International Edition on April 27 ,2020. The article conveys some information:

We report that Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone), an air-stable 18-electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel-catalyzed synthetic methods from the literature. Due to its apparent stability, use of Ni(COD)(DQ) as a precatalyst allows reactions to be conveniently performed without use of an inert-atm. glovebox, as demonstrated across several case studies. The experimental process involved the reaction of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Related Products of 258278-25-0)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) may be used as a precursor to the free carbene 1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene, and also used as an in situ formed catalyst in a variety of reactions, e.g. amination, Heck coupling reaction, the ring-opening metathesis polymerization (ROMP), hydrogenation.Related Products of 258278-25-0In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2003,Australian Journal of Chemistry included an article by Indusegaram, Sutharsiny; Katsifis, Andrew G.; Ridley, Damon D.; Vonwiller, Simone C.. Formula: C10H12N2O. The article was titled 《Nitrogen versus Oxygen Group Protection in Hydroxypropylbenzimidazoles》. The information in the text is summarized as follows:

In order to convert 1’H-benzimidazol-2′-yl-propanols into aryl ethers using Mitsunobu coupling, it was necessary to protect the benzimidazole nitrogen in the starting alcs. Selective protection at nitrogen was achieved through N-benzyl derivatives, but attempts to protect the nitrogen directly through tert-butoxycarbonyl, acetyl, trityl, or tetrahydropyranyl derivatives were complicated either by selective reactions at oxygen or by the formation of bis-protected compounds Transformations of some oxygen-protected derivatives are discussed, and in particular the conversion of the acetates of 1’H-benzimidazol-2′-yl-propanols to N-tetrahydropyranyl derivatives is described. Mitsunobu coupling involving the N-benzyl and N-tetrahydropyranyl derivatives and Me 4-hydroxybenzoate were achieved, and thus afforded synthetic routes to the desired propylbenzimidazole aryl ethers. The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Formula: C10H12N2O)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Formula: C10H12N2O However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xiao, Junzhe; Cui, Yifan; Li, Can; Xu, Haibo; Zhai, Yizhan; Zhang, Xue; Ma, Shengming published their research in Angewandte Chemie, International Edition on December 1 ,2021. The article was titled 《Room Temperature Allenation of Terminal Alkynes with Aldehydes》.Computed Properties of C27H39ClN2 The article contains the following contents:

A gold-catalyzed room temperature allenation of terminal alkynes (ATA) with aldehydes affording 1,3-disubstituted allenes with diverse functional groups was developed by identifying a gold(I) catalyst and an amine. The practicality of this reaction had been demonstrated by a ten gram-scale synthesis and the synthetic potentials have been demonstrated via various transformations and formal total synthesis of (-)-centrolobine. Mechanistic studies revealed that the gold catalyst, the aldehyde effect, the fluoroalkyl hydroxyl solvent (TFE or HFIP) and the structure of amine were vital in this room temperature ATA reaction. In the experimental materials used by the author, we found 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Computed Properties of C27H39ClN2)

1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Computed Properties of C27H39ClN2In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yamanaka, Motosuke; Miyake, Kazutoshi; Suda, Shinji; Ohhara, Hideto; Ogawa, Toshiaki published their research in Chemical & Pharmaceutical Bulletin on December 31 ,1991. The article was titled 《Imidazo[1,2-a]pyridines. I. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives. [Erratum to document cited in CA115(15):159040c]》.Recommanded Product: 136117-70-9 The article contains the following contents:

An error in Chart 3 has been corrected An error in Table III has been corrected Three errors in the text have been corrected The errors were not reflected in the abstract but were reflected in the index entries. After reading the article, we found that the author used Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Recommanded Product: 136117-70-9)

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 136117-70-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2009,Truong, Anh P.; Aubele, Danielle L.; Probst, Gary D.; Neitzel, Martin L.; Semko, Chris M.; Bowers, Simeon; Dressen, Darren; Hom, Roy K.; Konradi, Andrei W.; Sham, Hing L.; Garofalo, Albert W.; Keim, Pamela S.; Wu, Jing; Dappen, Michael S.; Wong, Karina; Goldbach, Erich; Quinn, Kevin P.; Sauer, John-Michael; Brigham, Elizabeth F.; Wallace, William; Nguyen, Lan; Hemphill, Susanna S.; Bova, Michael P.; Basi, Guriqbal published 《Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C3H3BrN2 The information in the text is summarized as follows:

In this letter, a strategy is reported to design potent and metabolically stable γ-secretase inhibitors that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose. Example synthetic routes toward a number of arylsulfonyl-substituted benzo- and heterocycle-fused pyrazolopiperidines are reported, and compound I is shown to be a metabolically stable effective γ-secretase inhibitor at sub-nanomolar levels. In the experimental materials used by the author, we found 2-Bromo-1H-imidazole(cas: 16681-56-4Electric Literature of C3H3BrN2)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Electric Literature of C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2010,Truong, Anh P.; Aubele, Danielle L.; Probst, Gary D.; Neitzel, Martin L.; Semko, Chris M.; Bowers, Simeon; Dressen, Darren; Hom, Roy K.; Konradi, Andrei W.; Sham, Hing L.; Garofalo, Albert W.; Keim, Pamela S.; Wu, Jing; Dappen, Michael S.; Wong, Karina; Goldbach, Erich; Quinn, Kevin P.; Sauer, John-Michael; Brigham, Elizabeth F.; Wallace, William; Nguyen, Lan; Hemphill, Susanna S.; Bova, Michael P.; Bard, Frederique; Yednock, Ted A.; Basi, Guriqbal published 《Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors. [Erratum to document cited in CA151:448310]》.Bioorganic & Medicinal Chemistry Letters published the findings.Name: 2-Bromo-1H-imidazole The information in the text is summarized as follows:

The names Frederique Bard and Ted A. Yednock were omitted from the author line on page 4920. The corrected author line, including the affiliations of the omitted authors, is given.2-Bromo-1H-imidazole(cas: 16681-56-4Name: 2-Bromo-1H-imidazole) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Name: 2-Bromo-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Clinical Chemistry and Laboratory Medicine included an article by Saenger, Amy K.; Jaffe, Allan S.; Body, Richard; Collinson, Paul O.; Kavsak, Peter A.; Lam, Carolyn S. P.; Lefevre, Guillaume; Omland, Tobjorn; Ordonez-Llanos, Jordi; Pulkki, Kari; Apple, Fred S.. Category: imidazoles-derivatives. The article was titled 《Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)》. The information in the text is summarized as follows:

Two interferences recently brought to the forefront as patient safety issues include hemolysis (Hb) and biotin (vitamin B7). The International Federation for Clin. Chem. Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker anal. results that are discordant with the clin. situation. The results came from multiple reactions, including the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Category: imidazoles-derivatives)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Category: imidazoles-derivatives The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Applied Laboratory Medicine included an article by Bevins, Nicholas J.; Hubbard, Jacqueline A.; Fitzgerald, Robert L.; Kelner, Michael J.. HPLC of Formula: 58-85-5. The article was titled 《A dilution method to mitigate biotin interference in cardiac troponin T testing》. The information in the text is summarized as follows:

Background: Oral biotin supplementation is known to interfere with biotin-streptavidin-based immunoassays, including Roche’s fifth-generation cardiac troponin T (cTnT) assay, which plays a critical role in the diagnosis of myocardial infarction (MI). The utility of dilution, a quick and easy method to detect and remove interferences, has not been published for biotin interference. Methods: Concentrations of cTnT were measured in pooled serum from clin. samples. Serum samples were supplemented with biotin to known concentrations, then cTnT concentrations were remeasured to assess for biotin interference. Samples were then diluted to assess for effective removal of biotin interference. Results: At cTnT values near the critical reporting range for our institution (100 ng/L) we observed significant interference in measured values with added biotin concentrations above 50 ng/mL. In specimens without added biotin, autodilution at a 1:10 ratio yielded a mean 157% capture of measured cTnT, precluding the use of autodilution for detecting and mitigating biotin interference. A 1:10 dilution with serum containing 20-30 ng/L cTnT yielded a mean capture of 107%, which was suitable for detecting underlying biotin interference in supplemented samples. Conclusions: Biotin interference, at supraphysiol. concentrations, may create an artifactual reduction in measured cTnT to levels that could lead to delayed detection of an MI. Dilution with serum of known cTnT concentration of 20-30 ng/L is a fast and effective method to mitigate the anal. consequences of biotin interference. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5HPLC of Formula: 58-85-5) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.HPLC of Formula: 58-85-5 And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Stereodefined Access to Lactams via Olefin Difunctionalization: Iridium Nitrenoids as a Motif of LUMO-Controlled Dipoles》 were Hong, Seung Youn; Chang, Sukbok. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 530-62-1 The author mentioned the following in the article:

Reported herein is a general platform of a stereodefined access to γ-lactams via Cp*Ir-catalyzed olefin difunctionalization, where in situ generated Ir-nitrenoid is utilized as a key motif of 1,3-dipoles to enable amido transfer in a syn-selective manner. Computational studies suggested that the stereodefined process can be attributed to the proposed working mode of concerted [3+2] cyclization. Frontier MO (FMO) anal. implied that a low-lying LUMO (LUMO) of the Ir-imido fragment engages in the olefin interaction. Mechanistic understanding on the nitrene transfer process led us to develop mild catalytic protocols of stereoselective difunctionalization of alkenyl dioxazolones to furnish α-(haloalkyl)- or (oxyalkyl)lactam products which are of high synthetic and medicinal utility. Product stereochem. (threo and erythro) was found to be designated by the olefin geometry (E/Z) of substrates. In the part of experimental materials, we found many familiar compounds, such as Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Effects of 1-butyl-3-methylimidazolium tetrafluoroborate and the oxygen concentration on the spontaneous combustion of coal》 were Xiao, Yang; Li, Da-Jiang; Lu, Hui-Fei; Yin, Lan; Shu, Chi-Min. And the article was published in Journal of Thermal Analysis and Calorimetry in 2019. Related Products of 174501-65-6 The author mentioned the following in the article:

Ionic liquids (ILs) are a type of environmentally friendly solvents. Several studies have proven that ILs can inhibit the spontaneous combustion of coal (SCC). In this study, a synchronous thermal analyzer was used to analyze the effects of the imidazolium-based IL [BMIM][BF4] on coal of three metamorphic grades. A coal sample exhibiting the optimal inhibiting result was selected to investigate the effect of the oxygen concentration on IL inhibition. The results revealed that the influence of IL on the mass loss process of the three metamorphic grades of coal varied considerably. However, the IL promoted the mass loss process in 1/3 coking coal and anthracite. The IL delayed the ignition temperature of lignite by 42°C, whereas those of 1/3 coking coal and anthracite were advanced by 10 and 8°C, resp. Furthermore, the initial exothermic temperature of the three treated coal samples was higher than those of the raw coal samples. Compared with the raw coal samples, the heat released per g of lignite, 1/3 coking coal, and anthracite was reduced by 1142, 353, and 226 J, resp. The results indicated that the IL had a prominent inhibiting effect on the exothermic properties of the three coal samples, and the inhibiting effect decreased with an increase in the metamorphic grade of coal. Moreover, the oxygen concentration did not alter the inhibition properties of the IL on the SCC. However, the inhibiting effect weakened as the oxygen concentration decreased. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Related Products of 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Related Products of 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem