On February 29, 2012, Zhao, Shan-shan; Lu, Hua; Zhang, Yue-cheng; Zhao, Ji-quan published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Application of D(-)-di-pyridylmethyl tartaric acid amide in the synthesis of esomeprazole through asymmetric oxidation. And the article contained the following:
Two di-pyridylmethyl D (-)-tartaric acid amides 2 and 3 were resp. prepared through the reaction of (-)-di-Et D-tartrate(1) with 2-aminomethyl pyridine and 4-aminomethyl pyridine. The compounds 1, 2 and 3 coordinated with iso-Pr titanate, resp., were used as catalyst in the asym. oxidation of the precursor (Eso-I) of esomeprazole with cumene hydroperoxide (CHP) as oxidant. The results revealed that both the catalytic systems derived from ligand 2 and 3 and iso-Pr titanate showed good catalytic activity and enantioselectivity in the synthesis of esomeprazole. For example, the conversion of Eso-I, the selectivity toward to the esomeprazole and the enantio excess reached 84.7%, 91.8% and 89.0%, resp., when 2 was used as the ligand and the reaction was conducted in toluene under the optimized conditions. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
The Article related to dipyridylmethyl tartaric acid amide esomeprazole asym oxidation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem