Barbin, A. published an article in 1999, the title of the article was Role of etheno DNA adducts in carcinogenesis induced by vinyl chloride in rats.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:
A review and discussion with many references Vinyl chloride, a hepatocarcinogen in humans and rodents, can form promutagenic ethano bases in DNA after metabolic activation. The formation of 1,N6-ethenoadenine (εA) and 3,N4-ethenocytosine (εC) was measured in adult Sprague-Dawley rats by immunoaffinity purification and 32P-post-labeling. A highly variable background was found in all tissues from untreated animals: the mean molar ratios of εA:A and εC:C in DNA ranged from 0.043 × 10-8 to 31.2 × 10-8 and from 0.062 × 10-8 to 20.4 × 10-8, resp. After exposure to 500 ppm vinyl chloride by inhalation (4 h/day, 5 days/wk for 8 wk), increased levels of εA were found in the liver, lung, circulating lymphocytes and testis, the mean (± SD) of induced levels (treated-control values) being (4.1±1.5) × 10-8 for these tissues. No increase in the εA:A ratio was observed in kidney, brain or spleen. The levels of εC increased in all the tissues examined except the brain. The mean value of the induced εC:C ratios was (7.8±1.2) × 10-8 for the liver, kidney, lymphocytes and spleen, and these ratios were higher in the lung (28×10-8) and testis (19×10-8). The results suggest a variable repair capacity for εA or εC in different tissues. The results are discussed in relation to published studies on the accumulation and persistence of etheno bases in the liver during and after exposure to vinyl chloride and on mutation spectra in the ras and p53 genes in liver tumors induced by vinyl chloride. In addition, we show that the linear relationship established for monofunctional alkylating agents between their carcinogenic potency in rodents and their covalent binding index for promutagenic bases in hepatic DNA holds for vinyl chloride. It is concluded that etheno bases are critical lesions in hepatocarcinogenesis induced by vinyl chloride. For a better understanding of the mechanism of action of this compound, further work is needed on the role of DNA repair pathways and of endogenous lipid peroxidation products in the formation and persistence of etheno bases in vivo. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one
The Article related to etheno dna adduct carcinogenesis vinyl chloride, review etheno dna adduct carcinogenesis vinyl chloride, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one
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