Barbin, Alain; Bartsch, Helmut; Lecomte, Philippe; Radman, Miroslav published an article in 1981, the title of the article was On the possible role of the miscoding DNA lesions, 1,N6-ethenoadenine and 3,N4-ethenocytosine, in vinyl chloride-induced mutagenesis and carcinogenesis.Related Products of 55662-66-3 And the article contains the following content:
chloroacetaldehyde [107-20-0] And chloroethylene oxide (CEO) [7763-77-1], 2 reactive metabolites of vinyl chloride [75-01-4], were used to introduce increasing amounts of 1,N6-ethenoadenine (εA)(I) [13875-63-3] and 3,N4-ethenocytosine (εC)(II) [55662-66-3] residues in poly(dA) [25191-20-2] and poly(dC) [25609-92-1], resp. The modified polynucleotides were assayed with Escherichia coli DNA polymerase I for their template activity and misincorporation. The miscoding properties observed of εA and εC may explain the mutagenic effects reported for vinyl chloride and its metabolites; these lesions may also represent one of the initial steps in vinyl chloride- or CEO-induced carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Related Products of 55662-66-3
The Article related to vinyl chloride mutagenesis dna miscoding, carcinogenesis vinyl chloride ethenoadenine ethenocytosine, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Related Products of 55662-66-3
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Imidazole | C3H4N2 – PubChem