On February 1, 1994, Dosanjh, M. K.; Chenna, A.; Kim, E.; Fraenkel-Conrat, H.; Samson, L.; Singer, B. published an article.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. And the article contained the following:
The authors have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (εA)-binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and εA from DNA treated with methylating agents or the vinyl chloride metabolite chloroacetaldehyde, resp. The authors now find that both the partially purified human εA-binding protein and cell-free extracts containing the cloned human m3A-DNA glycosylase release all 4 cyclic etheno adducts – namely εA, 3,N4-ethenocytosine (εC), N2,3-ethenoguanine (N2,3-εG), and 1,N2-ethenoguanine (1,N2-εG). Base release was both time- and protein concentration-dependent. Both εA and εC were excised at similar rates, while 1,N2-εG and N2,3-εG were released much more slowly under identical conditions. The cleavage of glycosyl bonds of several heterocyclic adducts as well as those of simple methylated adducts by the same human glycosylase appears unusual in enzymol. This raises the question of how such a multiple, divergent activity evolved in humans and what may be its primary substrate. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one
The Article related to chloroacetaldehyde cyclic etheno adduct release, methyladenine dna glycosylase human chloroacetaldehyde, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem