On October 26, 1982, Kusmierek, J. T.; Singer, B. published an article.Recommanded Product: 55662-66-3 The title of the article was Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 1. Reaction products. And the article contained the following:
The in vitro reaction of the vinyl chloride metabolite chloracetaldehyde (CAA) [107-20-0] with cytosine and adenine residues in ribo- and deoxyribopolynucleotides leads to the formation of the relatively stable hydrated etheno derivatives 3,N4-(N4-α-hydroxyethano)cytosine (εC.H2O) [66547-58-8] and 1,N6-(N6-α-hydroxyethano)adenine (εA.H2O) [69260-72-6]. Under physiol. conditions, the hydrates are slowly converted to 3,N4-ethenocytosine (εC)(I) [55662-66-3] and 1,N6-ethenoadenine (εA) [13875-63-3]. The half-life at pH 7.25 of εC.H2O in poly(C) is 4.9 h at 50° and of εA.H2O in poly(A) is 1.4 h at 37°. These dehydration rates in polymers are similar to those for hydrates in monomers. The reactivity of adenine and cytosine residues is greatly suppressed in double-stranded polymers. Adenine residues are ∼10 times less reactive in poly(A).poly(U) than adenine in single-stranded polymers. Under similar reaction conditions no reaction of cytosine residues in poly(C).poly(G) was detected. In vinyl chloride exposed cells, where CAA is formed, the cyclic etheno derivatives of adenine and cytosine are likely to occur preferentially in single-stranded regions of nucleic acids, with the hydrate forming a major proportion of the modification. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Recommanded Product: 55662-66-3
The Article related to chloracetaldehyde reaction nucleic acid, polynucleotide reaction chloracetaldehyde, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem