On January 16, 1994, Simha, Devendranath; Yadav, Deepmala; Rzepka, Robert W.; Palejwala, Vaseem A.; Humayun, M. Zafri published an article.Computed Properties of 55662-66-3 The title of the article was Base incorporation and extension at a site-specific ethenocytosine by Escherichia coli DNA polymerase I Klenow fragment. And the article contained the following:
Ethenocytosine (εC) is a highly mutagenic exocyclic DNA lesion induced by carcinogens vinyl chloride and urethane. The authors have examined base incorporation and extension at a site-specific εC residue by a quant. gel electrophoretic assay using an exonuclease-deficient version of Escherichia coli DNA polymerase I (Klenow fragment) as the model enzyme. The data show that the KM for incorporation of adenine or thymine opposite εC by is about 5 orders of magnitude higher than that for the incorporation of guanine opposite normal cytosine. The KM for base extension past εC:A and εC:T pairs is 1-2 orders of magnitude higher than that observed for a C:G pair. Although adenine misinsertion is favored over that of thymine, base extension occurs more readily when the base incorporated opposite εC is thymine. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Computed Properties of 55662-66-3
The Article related to ethenocytosine base incorporation extension escherichia polymerase, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Computed Properties of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem