Talhaoui, Ibtissam; Couve, Sophie; Ishchenko, Alexander A.; Kunz, Christophe; Schaer, Primo; Saparbaev, Murat published an article in 2013, the title of the article was 7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.Computed Properties of 55662-66-3 And the article contains the following content:
Hydroxyl radicals predominantly react with the C8 of purines in DNA forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway. Here, the authors report for the 1st time that human thymine-DNA glycosylase (hTDG) and Escherichia coli mismatch-specific uracil-DNA glycosylase (MUG) can remove 8oxoA from 8oxoA·T, 8oxoA·G, and 8oxoA·C pairs. Comparison of the kinetic parameters of the reaction indicated that full-length hTDG excised 8oxoA, 3,N4-ethenocytosine (εC) and T with similar efficiency (kmax = 0.35, 0.36, and 0.16 min-1, resp.) and was more proficient as compared with its bacterial homolog MUG. The N-terminal domain of the hTDG protein was essential for 8oxoA-DNA glycosylase activity, but not for εC repair. Interestingly, the TDG status had little or no effect on the proliferation rate of mouse embryonic fibroblasts after exposure to γ-irradiation Nevertheless, using whole cell-free extracts from DNA glycosylase-deficient murine embryonic fibroblasts and E. coli, the authors demonstrated that the excision of 8oxoA from 8oxoA·T and 8oxoA·G had an absolute requirement for TDG and MUG, resp. The data established that MUG and TDG can counteract the genotoxic effects of 8oxoA residues in vivo. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Computed Properties of 55662-66-3
The Article related to dna repair oxoadenine removal uracil thymine glycosylase, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Computed Properties of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem