Beaman, Alden G.; Tautz, William; Gabriel, Thomas; Keller, Oscar; Loome, Voldemar; Duschinsky, Robert published an article in 1965, the title of the article was Studies in the Nitroimidazole series. I. Synthesis of azomycin and related compounds.Reference of 2-Nitro-1H-benzo[d]imidazole And the article contains the following content:
Azomycin (2-nitroimidazole) was synthesized in 50% yield by treatment of 2-aminoimidazole with HONO in the presence of CuSO4 (Jones and Robins, CA 55, 559c). Synthetic azomycin was identified with natural azomycin by mixed m.p., by Pka, by uv and ir and by its in vitro anti-bacterial spectrum against 19 microorganisms. The method was also applied to the preparation of alkyl-2-aminoimidazoles and to 2-aminobenzimidazoles. The resulting 2-nitro compounds were then alkylated in the 1-position. When treated with alkali, the 1-alkyl-2-nitroimidazoles were more stable than the 1-alkyl-2-nitrobenzimidazoles which were transformed into 2-benzimidazolinones. The compounds were tested microbiol. by agar diffusion-cup plate employing a complex nitrogenous medium. Growth inhibition characteristics for the various compounds against a number of bacteria were given. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Reference of 2-Nitro-1H-benzo[d]imidazole
2-Nitro-1H-benzo[d]imidazole(cas:5709-67-1) belongs to imidazoles. It is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Reference of 2-Nitro-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem