Bochtler, Matthias; Fernandes, Humberto published an article in 2021, the title of the article was DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage.SDS of cas: 443-72-1 And the article contains the following content:
A Review. 6-Methyladenine (6mA) is fairly abundant in nuclear DNA of basal fungi, ciliates and green algae. In these organisms, 6mA is maintained near transcription start sites in ApT context by a parental-strand instruction dependent maintenance methyltransferase and is pos. associated with transcription. In animals and plants, 6mA levels are high only in organellar DNA. The 6mA levels in nuclear DNA are very low. They are attributable to nucleotide salvage and the activity of otherwise mitochondrial METTL4, and may be considered as a price that cells pay for adenine methylation in RNA and/or organellar DNA. Cells minimize this price by sanitizing dNTP pools to limit 6mA incorporation, and by converting 6mA that has been incorporated into DNA back to adenine. Hence, 6mA in nuclear DNA should be described as an epigenetic mark only in basal fungi, ciliates and green algae, but not in animals and plants. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1
The Article related to review dna adenine methylation eukaryotes, 6ma, dna damage, dna modifications, cancer, epitranscriptome/epigenome, nucleotide salvage, transcription, Biochemical Genetics: Reviews and other aspects.SDS of cas: 443-72-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem