On November 25, 1997, Hang, B.; Singer, B.; Margison, G. P.; Elder, R. H. published an article.Synthetic Route of 55662-66-3 The title of the article was Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. And the article contained the following:
It has previously been reported that 1,N6-ethenoadenine (εA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3,N4-ethenocytosine (εC), are released from DNA in vitro by the DNA repair enzyme alkylpurine-DNA-N-glycosylase (APNG). To assess the potential contribution of APNG to the repair of each of these mutagenic lesions in vivo, we have used cell-free extracts of tissues from APNG-null mutant mice and wild-type controls. The ability of these extracts to cleave defined oligomers containing a single modified base was determined The results showed that both testes and liver cells of these knockout mice completely lacked activity toward oligonucleotides containing εA and Hx, but retained wild-type levels of activity for εC and 8-oxoG. These findings indicate that (i) the previously identified εA-DNA glycosylase and Hx-DNA glycosylase activities are functions of APNG; (ii) the two structurally closely related mutagenic adducts εA and εC are repaired by sep. gene products; and (iii) APNG does not contribute detectably to the repair of 8-oxoG. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Synthetic Route of 55662-66-3
The Article related to apng glycosylase dna excision repair, ethenoadenine hypoxanthine ethenocysteine apng glycosylase repair, mouse apng glycosylase dna excision repair, Biochemical Genetics: Genomic Processes and other aspects.Synthetic Route of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem