On November 30, 1993, Helmenstine, A.; Uziel, M.; Vo-Dinh, T. published an article.Application of 55662-66-3 The title of the article was Measurement of DNA adducts using surface-enhanced Raman spectroscopy. And the article contained the following:
Many hazardous pollutants have chem. groups of toxicol. importance that can be characterized and detected by Raman spectroscopy. Raman spectroscopists have recently been able to analyze dilute biol. samples as a result of enhancements in the Raman scattering cross section by factors up to 1010 when a compound is adsorbed on or near a special electron-conducting surface. These spectacular enhancement factors of the normally weak Raman scattering process help overcome the low sensitivity of Raman spectroscopy through a combination of electromagnetic and chem. interactions between the analyte mol. and the surface. The technique associated with this phenomenon is known as surface-enhanced Raman scattering spectroscopy (SERS). The special conductive surface responsible for the scattering enhancement is referred to as a SERS substrate. For the past few years the authors have developed the SERS technique, using practical SERS-active substrate materials based on silver-coated microspheres deposited on glass. A wide variety of biomarkers have been investigated, including benzo[a]pyrene, dibenz[a,h]anthracene epoxides, 1,N6-ethenoadenine, 3,N4-ethenocytosine, and other substances. These biomarkers were measured at a nanogram and subnanogram levels. The exptl. results are of great anal. interest, since these chems. are difficult to detect by other techniques, such as luminescence spectroscopy, because of the weak luminescence quantum yields of these DNA adducts. In this paper the potential usefulness of the SERS technique for assessing environmental and health effects from human exposure to toxic pollutants is demonstrated. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application of 55662-66-3
The Article related to dna adduct carcinogen determination raman spectroscopy, surface enhanced raman spectroscopy dna adduct, Toxicology: Methods (Including Analysis) and other aspects.Application of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem