On January 20, 2021, Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Marimuthu, Kalisvar; De, Partha Pratim; Ng, Oon Tek; Li, Peng; Zhu, Yabin; Pethe, Kevin; Chan-Park, Mary B. published an article.Synthetic Route of 5036-48-6 The title of the article was Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics. And the article contained the following:
Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with min. inhibitory concentrations (MICs) of 8-32μg/mL against clin. relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clin. relevant antibiotics proved by decreasing the MICs of the antibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1μg/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via i.p. injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log10 reduction of A. baumannii in murine i.p. and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6
The Article related to antimicrobial chitosan derivative synergistic antibiotic, antibacterial, biocompatible, chitosan derivatives, nanoparticle, synergistic effect with antibiotics, Industrial Carbohydrates: Nonsugars and other aspects.Synthetic Route of 5036-48-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem